STRINGSTRING
AXIN1 AXIN1 STRN3 STRN3 LEF1 LEF1 CHD8 CHD8 TCF7L2 TCF7L2 CTNNBIP1 CTNNBIP1 CNOT1 CNOT1 STRN STRN STRN4 STRN4 CALCOCO1 CALCOCO1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AXIN1Axin 1. (865 aa)
STRN3Striatin 3. (797 aa)
LEF1Lymphoid enhancer binding factor 1. (432 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2592 aa)
TCF7L2Transcription factor 7 like 2. (619 aa)
CTNNBIP1Catenin beta interacting protein 1. (81 aa)
CNOT1CCR4-NOT transcription complex subunit 1. (2379 aa)
STRNStriatin. (657 aa)
STRN4Striatin 4. (666 aa)
CALCOCO1Calcium binding and coiled-coil domain 1. (691 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.