(62 nodes) Negative regulation of ERK1 and ERK2 cascade network (Propithecus coquereli)

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	CHRNA9	Cholinergic receptor nicotinic alpha 9 subunit. (479 aa)
	SPRY3	Sprouty RTK signaling antagonist 3. (288 aa)
	ENSPCOP00000000202	Prohibitin. (262 aa)
	LIF	LIF interleukin 6 family cytokine. (202 aa)
	CHRNA10	Cholinergic receptor nicotinic alpha 10 subunit. (450 aa)
	SPRED3	Sprouty related EVH1 domain containing 3. (429 aa)
	EPHB2	EPH receptor B2. (1039 aa)
	EZR	Ezrin. (586 aa)
	PHB	Prohibitin. (272 aa)
	DUSP6	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
	ENSPCOP00000001369	Uncharacterized protein. (1468 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	C3orf33	Chromosome 3 open reading frame 33. (240 aa)
	TNIP1	TNFAIP3 interacting protein 1. (582 aa)
	XBP1	BZIP domain-containing protein. (377 aa)
	RGS14	Regulator of G protein signaling 14. (567 aa)
	VRK3	VRK serine/threonine kinase 3. (453 aa)
	ATF3	Activating transcription factor 3. (181 aa)
	DUSP4	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
	RPS6KA6	Non-specific serine/threonine protein kinase. (704 aa)
	PSCA	Prostate stem cell antigen. (124 aa)
	PTPN1	Tyrosine-protein phosphatase non-receptor type. (435 aa)
	NLRP12	NLR family pyrin domain containing 12. (941 aa)
	PTPRR	Protein tyrosine phosphatase receptor type R. (620 aa)
	DUPD1	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (220 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (415 aa)
	PIN1	Peptidyl-prolyl cis-trans isomerase. (163 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (244 aa)
	ENSPCOP00000013257	CLTH domain-containing protein. (182 aa)
	ENSPCOP00000014148	Uncharacterized protein. (733 aa)
	CSK	Tyrosine-protein kinase. (450 aa)
	SEMA6A	Semaphorin 6A; Belongs to the semaphorin family. (1047 aa)
	NLRP6	NLR family pyrin domain containing 6. (890 aa)
	C1QL4	Complement C1q like 4. (238 aa)
	SYNJ2BP	Synaptojanin 2 binding protein. (134 aa)
	SPRED1	Sprouty related EVH1 domain containing 1. (444 aa)
	SPRY2	Sprouty RTK signaling antagonist 2. (314 aa)
	ENSPCOP00000027120	Uncharacterized protein. (1243 aa)
	NDRG2	NDRG family member 2. (371 aa)
	SPRY1	Sprouty RTK signaling antagonist 1. (319 aa)
	DUSP10	Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
	GSTP1	Glutathione S-transferase pi 1; Belongs to the GST superfamily. (210 aa)
	WNK2	WNK lysine deficient protein kinase 2. (2211 aa)
	CRYBA1	Crystallin beta A1; Belongs to the beta/gamma-crystallin family. (215 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	LYN	Tyrosine-protein kinase. (512 aa)
	EMILIN1	Elastin microfibril interfacer 1. (1022 aa)
	SPRY4	Sprouty RTK signaling antagonist 4. (337 aa)
	FLCN	Folliculin. (579 aa)
	DUSP26	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (211 aa)
	ITGB1BP1	Integrin subunit beta 1 binding protein 1. (200 aa)
	ENSPCOP00000022475	Uncharacterized protein. (173 aa)
	DAB2	DAB adaptor protein 2. (769 aa)
	TBC1D10C	TBC1 domain family member 10C. (446 aa)
	ENSPCOP00000019705	Uncharacterized protein. (583 aa)
	DAB2IP	DAB2 interacting protein. (1209 aa)
	DUSP9	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (384 aa)
	FBLN1	Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (723 aa)
	SPRED2	Sprouty related EVH1 domain containing 2. (431 aa)
	ERRFI1	ERBB receptor feedback inhibitor 1. (460 aa)
	TIMP3	TIMP metallopeptidase inhibitor 3. (211 aa)
	DLG1	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (910 aa)

Your Current Organism:

Propithecus coquereli

NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATF3	SMAD4	ENSPCOP00000006485	ENSPCOP00000024999	Activating transcription factor 3.	Mothers against decapentaplegic homolog.	0.476
ATF3	XBP1	ENSPCOP00000006485	ENSPCOP00000003952	Activating transcription factor 3.	BZIP domain-containing protein.	0.680
CHRNA10	CHRNA9	ENSPCOP00000000246	ENSPCOP00000000087	Cholinergic receptor nicotinic alpha 10 subunit.	Cholinergic receptor nicotinic alpha 9 subunit.	0.705
CHRNA9	CHRNA10	ENSPCOP00000000087	ENSPCOP00000000246	Cholinergic receptor nicotinic alpha 9 subunit.	Cholinergic receptor nicotinic alpha 10 subunit.	0.705
CSK	DAB2IP	ENSPCOP00000030390	ENSPCOP00000019689	Tyrosine-protein kinase.	DAB2 interacting protein.	0.423
CSK	ENSPCOP00000019705	ENSPCOP00000030390	ENSPCOP00000019705	Tyrosine-protein kinase.	Uncharacterized protein.	0.608
CSK	EPHB2	ENSPCOP00000030390	ENSPCOP00000000714	Tyrosine-protein kinase.	EPH receptor B2.	0.415
CSK	LYN	ENSPCOP00000030390	ENSPCOP00000024889	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.926
CSK	PTEN	ENSPCOP00000030390	ENSPCOP00000001519	Tyrosine-protein kinase.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.699
CSK	PTPN1	ENSPCOP00000030390	ENSPCOP00000009086	Tyrosine-protein kinase.	Tyrosine-protein phosphatase non-receptor type.	0.672
CSK	PTPN2	ENSPCOP00000030390	ENSPCOP00000011917	Tyrosine-protein kinase.	Tyrosine-protein phosphatase non-receptor type.	0.711
CSK	PTPRR	ENSPCOP00000030390	ENSPCOP00000009853	Tyrosine-protein kinase.	Protein tyrosine phosphatase receptor type R.	0.497
CSK	SMAD4	ENSPCOP00000030390	ENSPCOP00000024999	Tyrosine-protein kinase.	Mothers against decapentaplegic homolog.	0.430
CSK	SPRY2	ENSPCOP00000030390	ENSPCOP00000027194	Tyrosine-protein kinase.	Sprouty RTK signaling antagonist 2.	0.414
CSK	SPRY3	ENSPCOP00000030390	ENSPCOP00000000118	Tyrosine-protein kinase.	Sprouty RTK signaling antagonist 3.	0.414
CSK	SPRY4	ENSPCOP00000030390	ENSPCOP00000023342	Tyrosine-protein kinase.	Sprouty RTK signaling antagonist 4.	0.414
CSK	WNK2	ENSPCOP00000030390	ENSPCOP00000025514	Tyrosine-protein kinase.	WNK lysine deficient protein kinase 2.	0.407
DAB2	DAB2IP	ENSPCOP00000021114	ENSPCOP00000019689	DAB adaptor protein 2.	DAB2 interacting protein.	0.671
DAB2IP	CSK	ENSPCOP00000019689	ENSPCOP00000030390	DAB2 interacting protein.	Tyrosine-protein kinase.	0.423
DAB2IP	DAB2	ENSPCOP00000019689	ENSPCOP00000021114	DAB2 interacting protein.	DAB adaptor protein 2.	0.671