STRINGSTRING
SIRT1 SIRT1 FOS FOS FAM167A FAM167A STUB1 STUB1 KCNK2 KCNK2 EGR1 EGR1 FNDC1 FNDC1 PTEN PTEN MST1 MST1 MTOR MTOR SIRT4 SIRT4 CYBB CYBB ENSPCOP00000002148 ENSPCOP00000002148 NFE2L2 NFE2L2 ENSPCOP00000002776 ENSPCOP00000002776 PMAIP1 PMAIP1 TIGAR TIGAR PDK1 PDK1 SUV39H2 SUV39H2 MYC MYC ENSPCOP00000003708 ENSPCOP00000003708 BMP7 BMP7 ENSPCOP00000003784 ENSPCOP00000003784 HIPK2 HIPK2 HMOX1 HMOX1 HYOU1 HYOU1 NOTCH1 NOTCH1 HIF1A HIF1A FABP1 FABP1 ENSPCOP00000005309 ENSPCOP00000005309 ERO1A ERO1A EPAS1 EPAS1 CCNA2 CCNA2 JUND JUND ENSPCOP00000006354 ENSPCOP00000006354 RBPJ RBPJ EGLN3 EGLN3 AQP1 AQP1 PTGS2 PTGS2 NOP53 NOP53 CASR CASR RPTOR RPTOR ANGPT4 ANGPT4 CPEB1 CPEB1 ENSPCOP00000011649 ENSPCOP00000011649 SIRT2 SIRT2 TREM2 TREM2 SLC8A1 SLC8A1 STOX1 STOX1 ENSPCOP00000013232 ENSPCOP00000013232 SLC2A4 SLC2A4 NDRG1 NDRG1 OPRD1 OPRD1 P4HB P4HB ENSPCOP00000014340 ENSPCOP00000014340 HIF1AN HIF1AN VHL VHL SLC8A3 SLC8A3 BNIP3 BNIP3 STC1 STC1 MLST8 MLST8 BBC3 BBC3 RGCC RGCC MGARP MGARP E2F1 E2F1 ADAM8 ADAM8 SRC SRC DDR2 DDR2 KCNMB1 KCNMB1 ENSPCOP00000019967 ENSPCOP00000019967 PDK3 PDK3 BCL2 BCL2 ZFP36L1 ZFP36L1 BACH1 BACH1 ENSPCOP00000021800 ENSPCOP00000021800 CITED2 CITED2 AQP3 AQP3 PTGIS PTGIS ATP7A ATP7A RORA RORA FAM162A FAM162A VEGFA VEGFA ENSPCOP00000024369 ENSPCOP00000024369 MDM4 MDM4 PINK1 PINK1 ENSPCOP00000025432 ENSPCOP00000025432 NKX3-1 NKX3-1 MPL MPL AK4 AK4 DNMT3A DNMT3A ENSPCOP00000025841 ENSPCOP00000025841 ATF2 ATF2 PRKCE PRKCE HP1BP3 HP1BP3 EGLN1 EGLN1 EGLN2 EGLN2 BNIP3L BNIP3L RTN4 RTN4 TBL2 TBL2 GATA6 GATA6 ENSPCOP00000027819 ENSPCOP00000027819 SLC29A1 SLC29A1 ENSPCOP00000028966 ENSPCOP00000028966 CPEB2 CPEB2 IRAK1 IRAK1 KCNK3 KCNK3 SFRP1 SFRP1 BAD BAD PPARD PPARD LMNA LMNA TP53 TP53 SLC9A1 SLC9A1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SIRT1Sirtuin 1. (743 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (381 aa)
FAM167AFamily with sequence similarity 167 member A. (217 aa)
STUB1STIP1 homology and U-box containing protein 1. (304 aa)
KCNK2Potassium two pore domain channel subfamily K member 2. (371 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (543 aa)
FNDC1Fibronectin type III domain containing 1. (1868 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2536 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa)
CYBBCytochrome b-245 beta chain. (533 aa)
ENSPCOP00000002148Uncharacterized protein. (118 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (606 aa)
ENSPCOP00000002776Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (330 aa)
PMAIP1Uncharacterized protein. (54 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
PDK1Protein-serine/threonine kinase. (438 aa)
SUV39H2Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (410 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (453 aa)
ENSPCOP00000003708Uncharacterized protein. (135 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
ENSPCOP00000003784Na_trans_assoc domain-containing protein. (129 aa)
HIPK2Homeodomain interacting protein kinase 2. (1187 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
HYOU1Hypoxia up-regulated 1. (997 aa)
NOTCH1Notch receptor 1. (2420 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
FABP1FABP domain-containing protein. (69 aa)
ENSPCOP00000005309Fe2OG dioxygenase domain-containing protein. (121 aa)
ERO1AEndoplasmic reticulum oxidoreductase 1 alpha. (385 aa)
EPAS1Endothelial PAS domain protein 1. (869 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
JUNDJunD proto-oncogene, AP-1 transcription factor subunit. (348 aa)
ENSPCOP00000006354ERAP1_C domain-containing protein. (413 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (523 aa)
EGLN3Fe2OG dioxygenase domain-containing protein. (239 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
NOP53Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (417 aa)
CASRCalcium sensing receptor. (1076 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1281 aa)
ANGPT4Angiopoietin 4. (499 aa)
CPEB1Uncharacterized protein. (589 aa)
ENSPCOP00000011649Peptidase_M1 domain-containing protein. (151 aa)
SIRT2Sirtuin 2. (469 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (224 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (974 aa)
STOX1Storkhead box 1. (980 aa)
ENSPCOP00000013232Protein-serine/threonine kinase. (359 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
NDRG1N-myc downstream regulated 1. (373 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (372 aa)
P4HBProtein disulfide-isomerase. (510 aa)
ENSPCOP00000014340Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (468 aa)
HIF1ANHypoxia inducible factor 1 subunit alpha inhibitor. (349 aa)
VHLVon Hippel-Lindau tumor suppressor. (208 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)
BNIP3Uncharacterized protein. (235 aa)
STC1Stanniocalcin 1. (247 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
BBC3BCL2 binding component 3. (260 aa)
RGCCRegulator of cell cycle. (137 aa)
MGARPMitochondria localized glutamic acid rich protein. (240 aa)
E2F1E2F transcription factor 1. (436 aa)
ADAM8ADAM metallopeptidase domain 8. (812 aa)
SRCTyrosine-protein kinase. (543 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
KCNMB1Potassium calcium-activated channel subfamily M regulatory beta subunit 1. (191 aa)
ENSPCOP00000019967Uncharacterized protein. (713 aa)
PDK3Protein-serine/threonine kinase. (352 aa)
BCL2BCL2 apoptosis regulator. (234 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
BACH1BTB domain and CNC homolog 1. (737 aa)
ENSPCOP00000021800Uncharacterized protein. (175 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
AQP3Aquaporin 3 (Gill blood group); Belongs to the MIP/aquaporin (TC 1.A.8) family. (292 aa)
PTGISProstacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (500 aa)
ATP7AATPase copper transporting alpha. (1502 aa)
RORARAR related orphan receptor A. (532 aa)
FAM162AFamily with sequence similarity 162 member A. (155 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
ENSPCOP00000024369Uncharacterized protein; Belongs to the intermediate filament family. (156 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (491 aa)
PINK1PTEN induced kinase 1. (581 aa)
ENSPCOP00000025432Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (747 aa)
NKX3-1NK3 homeobox 1. (226 aa)
MPLMPL proto-oncogene, thrombopoietin receptor. (634 aa)
AK4Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. (223 aa)
DNMT3ADNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (912 aa)
ENSPCOP00000025841Uncharacterized protein; Belongs to the adenylate kinase family. (171 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
HP1BP3Heterochromatin protein 1 binding protein 3. (499 aa)
EGLN1Uncharacterized protein. (427 aa)
EGLN2Egl-9 family hypoxia inducible factor 2. (405 aa)
BNIP3LBCL2 interacting protein 3 like. (219 aa)
RTN4Reticulon. (1195 aa)
TBL2Transducin beta like 2. (446 aa)
GATA6GATA binding protein 6. (593 aa)
ENSPCOP00000027819Uncharacterized protein. (200 aa)
SLC29A1Solute carrier family 29 member 1 (Augustine blood group). (456 aa)
ENSPCOP00000028966Uncharacterized protein. (188 aa)
CPEB2Cytoplasmic polyadenylation element binding protein 2. (937 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (713 aa)
KCNK3Potassium channel subfamily K member. (394 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
BADBCL2 associated agonist of cell death. (168 aa)
PPARDPeroxisome proliferator activated receptor delta. (440 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (665 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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