STRINGSTRING
WNT4 WNT4 DAB2 DAB2 ZFP36L1 ZFP36L1 FUT8 FUT8 ENG ENG PAK2 PAK2 COL1A1 COL1A1 ONECUT2 ONECUT2 ITGA8 ITGA8 PENK PENK PML PML ZEB1 ZEB1 GDF5 GDF5 LTBP3 LTBP3 CDH5 CDH5 SMAD9 SMAD9 TGFBR1 TGFBR1 DDR2 DDR2 SRC SRC CRK CRK COL4A2 COL4A2 APAF1 APAF1 CX3CR1 CX3CR1 ITGB8 ITGB8 ACVR1 ACVR1 TGFBR3 TGFBR3 NLK NLK MAPK7 MAPK7 NRROS NRROS CILP CILP PDE3A PDE3A SOX5 SOX5 MSTN MSTN EPB41L5 EPB41L5 FSHB FSHB PXN PXN TWSG1 TWSG1 AMHR2 AMHR2 FERMT2 FERMT2 BMPR1A BMPR1A USP15 USP15 FURIN FURIN ENSPCOP00000011221 ENSPCOP00000011221 PARP1 PARP1 LOC105824854 LOC105824854 FOS FOS SMAD5 SMAD5 SMAD2 SMAD2 COL3A1 COL3A1 DLX1 DLX1 ENSPCOP00000000722 ENSPCOP00000000722 GCNT2 GCNT2 WNT7B WNT7B SMAD7 SMAD7 TGFB2 TGFB2 TGFBR2 TGFBR2 SMAD6 SMAD6 LTBP4 LTBP4 WNT7A WNT7A COL1A2 COL1A2 SOX6 SOX6 ITGB6 ITGB6 HIPK2 HIPK2 SKIL SKIL ITGB5 ITGB5 ZYX ZYX GLG1 GLG1 OVOL2 OVOL2 CITED1 CITED1 SMAD1 SMAD1 LOC105824853 LOC105824853 TGFB3 TGFB3 ZMIZ1 ZMIZ1 CLEC3B CLEC3B DUSP22 DUSP22 WNT5A WNT5A ZFP36L2 ZFP36L2 TGFBRAP1 TGFBRAP1 FYN FYN MEF2C MEF2C APPL1 APPL1 GDF10 GDF10 NODAL NODAL ID1 ID1 APPL2 APPL2 LRRC32 LRRC32 USP9X USP9X TP53 TP53 BAMBI BAMBI FMOD FMOD CLDN1 CLDN1 MTMR4 MTMR4 SKI SKI STK16 STK16 HPGD HPGD ZFYVE9 ZFYVE9 SFRP1 SFRP1 ENSPCOP00000030534 ENSPCOP00000030534 WNT2 WNT2 FGFR2 FGFR2 STAT3 STAT3 CRKL CRKL LIMS1 LIMS1 WNT10A WNT10A SOX9 SOX9 CDKN2B CDKN2B LTBP2 LTBP2 WFIKKN2 WFIKKN2 SIRT1 SIRT1 FBN1 FBN1 CAV2 CAV2 PDE2A PDE2A CHST11 CHST11 ARG1 ARG1 PTK2 PTK2 CAV1 CAV1 SMAD4 SMAD4 FN1 FN1 PDGFA PDGFA SCX SCX FOXH1 FOXH1 ANKRD1 ANKRD1 HYAL2 HYAL2 WWOX WWOX FNTA FNTA PPM1A PPM1A FLCN FLCN TGFB1 TGFB1 ACVRL1 ACVRL1 SMAD3 SMAD3 IGF1R IGF1R CITED2 CITED2 TGFBR3L TGFBR3L
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
DAB2DAB adaptor protein 2. (769 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
FUT8Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Belongs to the glycosyltransferase 23 family. (536 aa)
ENGEndoglin. (657 aa)
PAK2Non-specific serine/threonine protein kinase. (492 aa)
COL1A1Collagen type I alpha 1 chain. (1461 aa)
ONECUT2One cut domain family member. (433 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1035 aa)
PENKProenkephalin. (267 aa)
PMLPromyelocytic leukemia. (887 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1002 aa)
GDF5Growth differentiation factor 5. (499 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1306 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (786 aa)
SMAD9SMAD family member 9. (353 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (421 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
SRCTyrosine-protein kinase. (543 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
COL4A2Collagen type IV alpha 2 chain. (1711 aa)
APAF1Apoptotic peptidase activating factor 1. (1204 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (379 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (768 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
TGFBR3Transforming growth factor beta receptor 3. (851 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (802 aa)
NRROSNegative regulator of reactive oxygen species. (692 aa)
CILPCartilage intermediate layer protein. (1182 aa)
PDE3APhosphodiesterase. (1073 aa)
SOX5SRY-box transcription factor 5. (763 aa)
MSTNMyostatin. (376 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (731 aa)
FSHBFollicle stimulating hormone subunit beta. (129 aa)
PXNPaxillin. (1073 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (189 aa)
AMHR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (476 aa)
FERMT2Fermitin family member 2. (693 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (484 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (798 aa)
ENSPCOP00000011221FERM domain-containing protein. (471 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
LOC105824854Uncharacterized protein. (312 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (381 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
SMAD2Mothers against decapentaplegic homolog. (462 aa)
COL3A1Collagen type III alpha 1 chain. (1371 aa)
DLX1Distal-less homeobox 1. (255 aa)
ENSPCOP00000000722Protein kinase domain-containing protein. (67 aa)
GCNT2Glucosaminyl (N-acetyl) transferase 2 (I blood group). (329 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
SMAD7Mothers against decapentaplegic homolog. (490 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
SMAD6Mothers against decapentaplegic homolog. (500 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1626 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (190 aa)
COL1A2Collagen type I alpha 2 chain. (1364 aa)
SOX6SRY-box transcription factor 6. (828 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (766 aa)
HIPK2Homeodomain interacting protein kinase 2. (1187 aa)
SKILSKI like proto-oncogene. (664 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (802 aa)
ZYXZyxin. (570 aa)
GLG1Golgi glycoprotein 1. (1068 aa)
OVOL2Ovo like zinc finger 2. (276 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (221 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
LOC105824853Uncharacterized protein. (401 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1067 aa)
CLEC3BC-type lectin domain family 3 member B. (202 aa)
DUSP22Dual specificity phosphatase 22. (191 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ZFP36L2ZFP36 ring finger protein like 2. (493 aa)
TGFBRAP1Transforming growth factor beta receptor associated protein 1. (859 aa)
FYNTyrosine-protein kinase. (537 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (661 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (477 aa)
NODALNodal growth differentiation factor. (348 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (591 aa)
LRRC32Leucine rich repeat containing 32. (663 aa)
USP9XUbiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2581 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
FMODFibromodulin. (376 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
MTMR4Myotubularin related protein 4. (1196 aa)
SKISKI proto-oncogene. (718 aa)
STK16Serine/threonine kinase 16. (349 aa)
HPGD15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1424 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
ENSPCOP00000030534Uncharacterized protein. (49 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
FGFR2Fibroblast growth factor receptor. (797 aa)
STAT3Signal transducer and activator of transcription. (796 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
LIMS1LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (398 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
SOX9SRY-box transcription factor 9. (505 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1816 aa)
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (575 aa)
SIRT1Sirtuin 1. (743 aa)
FBN1Fibrillin 1. (2871 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
PDE2APhosphodiesterase. (940 aa)
CHST11Carbohydrate sulfotransferase. (352 aa)
ARG1Arginase. (229 aa)
PTK2Protein tyrosine kinase 2. (1089 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
FN1Fibronectin 1. (2290 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
SCXScleraxis bHLH transcription factor. (208 aa)
FOXH1Forkhead box H1. (367 aa)
ANKRD1Ankyrin repeat domain 1. (319 aa)
HYAL2Hyaluronidase. (473 aa)
WWOXWW domain containing oxidoreductase. (414 aa)
FNTAFarnesyltransferase, CAAX box, alpha. (309 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (455 aa)
FLCNFolliculin. (579 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa)
SMAD3Mothers against decapentaplegic homolog. (443 aa)
IGF1RTyrosine-protein kinase receptor. (1350 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
TGFBR3LTransforming growth factor beta receptor 3 like. (313 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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