STRINGSTRING
TEX12 TEX12 ENSPCOP00000000202 ENSPCOP00000000202 RPA1 RPA1 PHB PHB TK2 TK2 LIN9 LIN9 ENSPCOP00000002776 ENSPCOP00000002776 SPRTN SPRTN HROB HROB POT1 POT1 REV1 REV1 PCLAF PCLAF CENPF CENPF POLM POLM USP10 USP10 SMPD3 SMPD3 ENSPCOP00000007225 ENSPCOP00000007225 ENSPCOP00000008165 ENSPCOP00000008165 TENT4B TENT4B MAD2L2 MAD2L2 PCNA PCNA SYCP1 SYCP1 POLH POLH SPHK1 SPHK1 POLE4 POLE4 WRNIP1 WRNIP1 TK1 TK1 POLA1 POLA1 USP43 USP43 CCN2 CCN2 CDKN2D CDKN2D PIF1 PIF1 REV3L REV3L POLE POLE POLD1 POLD1 POLL POLL ARID3A ARID3A RFC3 RFC3 VCP VCP NHP2 NHP2 POLDIP2 POLDIP2 SRC SRC LOX LOX CHRAC1 CHRAC1 LOC105824103 LOC105824103 TERF2 TERF2 TERF1 TERF1 POLG POLG POLI POLI TELO2 TELO2 DTL DTL POLD4 POLD4 TYMS TYMS POLD2 POLD2 POLD3 POLD3 POLG2 POLG2 POLQ POLQ ENSPCOP00000025432 ENSPCOP00000025432 TEP1 TEP1 RCHY1 RCHY1 NOP10 NOP10 LIG3 LIG3 ZBTB1 ZBTB1 POLB POLB RFC1 RFC1 SPATA22 SPATA22 SIRT1 SIRT1 DKC1 DKC1 GAR1 GAR1 DNTT DNTT POLE2 POLE2 WRAP53 WRAP53 USP1 USP1 POLK POLK LIG1 LIG1 ACD ACD POLN POLN ENSPCOP00000030829 ENSPCOP00000030829 PARP10 PARP10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TEX12Testis expressed 12. (123 aa)
ENSPCOP00000000202Prohibitin. (262 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
PHBProhibitin. (272 aa)
TK2Thymidine kinase 2. (310 aa)
LIN9Lin-9 DREAM MuvB core complex component. (593 aa)
ENSPCOP00000002776Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (330 aa)
SPRTNUncharacterized protein. (493 aa)
HROBChromosome 17 open reading frame 53. (652 aa)
POT1Protection of telomeres 1. (600 aa)
REV1DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1197 aa)
PCLAFPAF domain-containing protein. (65 aa)
CENPFCentromere protein F. (2967 aa)
POLMDNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (491 aa)
USP10Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (798 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (656 aa)
ENSPCOP00000007225Uncharacterized protein. (492 aa)
ENSPCOP00000008165Uncharacterized protein. (177 aa)
TENT4BTerminal nucleotidyltransferase 4B. (607 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (235 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
SYCP1Synaptonemal complex protein 1. (767 aa)
POLHDNA polymerase eta. (709 aa)
SPHK1Sphingosine kinase 1. (469 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (118 aa)
WRNIP1WRN helicase interacting protein 1. (666 aa)
TK1Thymidine kinase. (232 aa)
POLA1DNA polymerase. (1442 aa)
USP43Ubiquitin specific peptidase 43; Belongs to the peptidase C19 family. (1122 aa)
CCN2Cellular communication network factor 2. (347 aa)
CDKN2DCyclin dependent kinase inhibitor 2D. (166 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (643 aa)
REV3LREV3 like, DNA directed polymerase zeta catalytic subunit. (3120 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2284 aa)
POLD1DNA polymerase. (1125 aa)
POLLDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (573 aa)
ARID3AAT-rich interaction domain 3A. (605 aa)
RFC3Replication factor C subunit 3. (356 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
NHP2Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (153 aa)
POLDIP2DNA polymerase delta interacting protein 2. (368 aa)
SRCTyrosine-protein kinase. (543 aa)
LOXLysyl oxidase. (416 aa)
CHRAC1Chromatin accessibility complex subunit 1. (133 aa)
LOC105824103Uncharacterized protein. (430 aa)
TERF2Telomeric repeat binding factor 2. (542 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (435 aa)
POLGDNA polymerase gamma, catalytic subunit. (1224 aa)
POLIDNA polymerase iota. (735 aa)
TELO2Telomere maintenance 2. (836 aa)
DTLDenticleless E3 ubiquitin protein ligase homolog. (784 aa)
POLD4Uncharacterized protein. (107 aa)
TYMSThymidylate synthetase. (313 aa)
POLD2DNA polymerase delta 2, accessory subunit. (504 aa)
POLD3DNA polymerase delta 3, accessory subunit. (359 aa)
POLG2DNA polymerase gamma 2, accessory subunit. (465 aa)
POLQDNA polymerase theta. (2280 aa)
ENSPCOP00000025432Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (747 aa)
TEP1Telomerase associated protein 1. (2562 aa)
RCHY1Ring finger and CHY zinc finger domain containing 1. (231 aa)
NOP10NOP10 ribonucleoprotein. (64 aa)
LIG3DNA ligase. (966 aa)
ZBTB1Zinc finger and BTB domain containing 1. (653 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (333 aa)
RFC1Replication factor C subunit 1. (1113 aa)
SPATA22Spermatogenesis associated 22. (363 aa)
SIRT1Sirtuin 1. (743 aa)
DKC1Dyskerin pseudouridine synthase 1. (514 aa)
GAR1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (196 aa)
DNTTDNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (511 aa)
POLE2DNA polymerase epsilon 2, accessory subunit. (439 aa)
WRAP53WD repeat containing antisense to TP53. (540 aa)
USP1Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (785 aa)
POLKDNA polymerase kappa. (832 aa)
LIG1DNA ligase. (916 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (513 aa)
POLNDNA polymerase nu. (899 aa)
ENSPCOP00000030829G-patch domain-containing protein. (169 aa)
PARP10Poly [ADP-ribose] polymerase. (985 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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