(59 nodes) Nephron tubule morphogenesis network (Propithecus coquereli)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	OSR1	Odd-skipped related transcription factor 1. (266 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	SOX9	SRY-box transcription factor 9. (505 aa)
	LGR4	Leucine rich repeat containing G protein-coupled receptor 4. (920 aa)
	BMP2	Bone morphogenetic protein 2. (395 aa)
	SALL1	Spalt like transcription factor 1. (1315 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (394 aa)
	LHX5	LIM homeobox 5. (402 aa)
	TCF21	Transcription factor 21. (179 aa)
	IRX1	Iroquois homeobox 1. (480 aa)
	GLI3	GLI family zinc finger 3. (1580 aa)
	GREB1L	GREB1 like retinoic acid receptor coactivator. (1781 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	WNK4	WNK lysine deficient protein kinase 4. (1242 aa)
	GPC3	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa)
	HS3ST3B1	Sulfotransferase; Belongs to the sulfotransferase 1 family. (390 aa)
	PKD1	Polycystin 1, transient receptor potential channel interacting. (4265 aa)
	FOXD1	Forkhead box D1. (467 aa)
	GREB1	Growth regulating estrogen receptor binding 1. (1891 aa)
	CITED1	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (221 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	HOXD11	Homeobox D11. (339 aa)
	ADAMTS16	ADAM metallopeptidase with thrombospondin type 1 motif 16. (1209 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	HES5	Orange domain-containing protein. (94 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
	GATA3	Uncharacterized protein. (444 aa)
	SIX1	SIX homeobox 1. (284 aa)
	PGF	Placental growth factor; Belongs to the PDGF/VEGF growth factor family. (220 aa)
	IRX2	Iroquois homeobox 2. (471 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	WNT6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	ENSPCOP00000013017	Uncharacterized protein. (47 aa)
	HS3ST3A1	Sulfotransferase; Belongs to the sulfotransferase 1 family. (406 aa)
	HOXA11	Homeobox A11. (316 aa)
	DLG1	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (910 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (963 aa)
	LAMA5	Laminin subunit alpha 5. (3694 aa)
	PAX2	Paired box 2. (417 aa)
	CTNNBIP1	Catenin beta interacting protein 1. (81 aa)
	WT1	WT1 transcription factor. (522 aa)
	IRX3	Iroquois homeobox 3. (505 aa)
	ENSPCOP00000018033	HH_signal domain-containing protein. (110 aa)
	LHX1	LIM homeobox 1. (406 aa)
	KLHL3	Kelch like family member 3. (587 aa)
	BCL2	BCL2 apoptosis regulator. (234 aa)
	KIF26B	Kinesin family member 26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2106 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	SOX8	SRY-box transcription factor 8. (462 aa)
	GDNF	Glial cell derived neurotrophic factor. (228 aa)
	PTCH1	Patched 1. (1449 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
	LZTS2	Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (671 aa)
	HS2ST1	Uncharacterized protein. (356 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	GZF1	GDNF inducible zinc finger protein 1. (710 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	TMEM59L	Transmembrane protein 59 like. (343 aa)

Your Current Organism:

Propithecus coquereli

NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAMTS16	IRX3	ENSPCOP00000007621	ENSPCOP00000017734	ADAM metallopeptidase with thrombospondin type 1 motif 16.	Iroquois homeobox 3.	0.463
BCL2	CTNNB1	ENSPCOP00000020794	ENSPCOP00000022753	BCL2 apoptosis regulator.	Catenin beta 1.	0.520
BMP2	BMP4	ENSPCOP00000030823	ENSPCOP00000028335	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.896
BMP2	CTNNB1	ENSPCOP00000030823	ENSPCOP00000022753	Bone morphogenetic protein 2.	Catenin beta 1.	0.469
BMP2	ENSPCOP00000018033	ENSPCOP00000030823	ENSPCOP00000018033	Bone morphogenetic protein 2.	HH_signal domain-containing protein.	0.538
BMP2	FGF2	ENSPCOP00000030823	ENSPCOP00000031028	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.562
BMP2	FGF8	ENSPCOP00000030823	ENSPCOP00000012774	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.455
BMP2	GPC3	ENSPCOP00000030823	ENSPCOP00000002430	Bone morphogenetic protein 2.	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.536
BMP2	NOG	ENSPCOP00000030823	ENSPCOP00000000944	Bone morphogenetic protein 2.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.995
BMP2	PTCH1	ENSPCOP00000030823	ENSPCOP00000022438	Bone morphogenetic protein 2.	Patched 1.	0.569
BMP2	SMAD4	ENSPCOP00000030823	ENSPCOP00000024999	Bone morphogenetic protein 2.	Mothers against decapentaplegic homolog.	0.923
BMP2	SOX9	ENSPCOP00000030823	ENSPCOP00000029276	Bone morphogenetic protein 2.	SRY-box transcription factor 9.	0.454
BMP4	BMP2	ENSPCOP00000028335	ENSPCOP00000030823	Bone morphogenetic protein 4.	Bone morphogenetic protein 2.	0.896
BMP4	CTNNB1	ENSPCOP00000028335	ENSPCOP00000022753	Bone morphogenetic protein 4.	Catenin beta 1.	0.472
BMP4	ENSPCOP00000018033	ENSPCOP00000028335	ENSPCOP00000018033	Bone morphogenetic protein 4.	HH_signal domain-containing protein.	0.640
BMP4	FGF2	ENSPCOP00000028335	ENSPCOP00000031028	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.501
BMP4	FGF8	ENSPCOP00000028335	ENSPCOP00000012774	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.470
BMP4	GPC3	ENSPCOP00000028335	ENSPCOP00000002430	Bone morphogenetic protein 4.	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.536
BMP4	NOG	ENSPCOP00000028335	ENSPCOP00000000944	Bone morphogenetic protein 4.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.987
BMP4	PTCH1	ENSPCOP00000028335	ENSPCOP00000022438	Bone morphogenetic protein 4.	Patched 1.	0.569