52 items (Propithecus coquereli) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	BAG6	BCL2 associated athanogene 6. (1124 aa)
	MSH2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (868 aa)
	ELL3	Elongation factor for RNA polymerase II 3. (396 aa)
	RRP8	Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (454 aa)
	POU4F1	POU domain protein. (421 aa)
	ZNF385B	Zinc finger protein 385B. (471 aa)
	PDK2	Protein-serine/threonine kinase. (407 aa)
	WWOX	WW domain containing oxidoreductase. (414 aa)
	DDX5	DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
	DYRK2	Dual specificity tyrosine phosphorylation regulated kinase 2. (601 aa)
	PERP	P53 apoptosis effector related to PMP22. (193 aa)
	PML	Promyelocytic leukemia. (887 aa)
	BAX	BCL2 associated X, apoptosis regulator. (199 aa)
	EP300	E1A binding protein p300. (2424 aa)
	DDIT4	DNA damage inducible transcript 4. (230 aa)
	SHISA5	Shisa family member 5. (239 aa)
	LOC105808398	Bis(5'-adenosyl)-triphosphatase. (148 aa)
	STK11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (442 aa)
	HIPK2	Homeodomain interacting protein kinase 2. (1187 aa)
	POU4F2	POU domain protein. (408 aa)
	PHLDA3	Pleckstrin homology like domain family A member 3. (125 aa)
	BOK	BCL2 family apoptosis regulator BOK. (213 aa)
	MYBBP1A	MYB binding protein 1a. (1342 aa)
	PPP1R13B	Protein phosphatase 1 regulatory subunit 13B. (1088 aa)
	CHEK2	Checkpoint kinase 2. (571 aa)
	ENSPCOP00000027261	Uncharacterized protein. (113 aa)
	SIRT1	Sirtuin 1. (743 aa)
	HIPK1	Homeodomain interacting protein kinase 1. (1131 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	PYCARD	PYD and CARD domain containing. (195 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
	BCL3	BCL3 transcription coactivator. (454 aa)
	E2F1	E2F transcription factor 1. (436 aa)
	AEN	Apoptosis enhancing nuclease. (325 aa)
	BBC3	BCL2 binding component 3. (260 aa)
	JMY	Junction mediating and regulatory protein, p53 cofactor. (935 aa)
	USP28	Ubiquitin specific peptidase 28; Belongs to the peptidase C19 family. (1061 aa)
	TP73	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (588 aa)
	ENSPCOP00000012261	Uncharacterized protein. (74 aa)
	ATAD5	ATPase family AAA domain containing 5. (1646 aa)
	CASP6	Caspase 6; Belongs to the peptidase C14A family. (293 aa)
	EDA2R	Ectodysplasin A2 receptor. (314 aa)
	CDIP1	Cell death inducing p53 target 1. (208 aa)
	ENSPCOP00000009093	Uncharacterized protein. (88 aa)
	TMEM109	Transmembrane protein 109. (243 aa)
	SNW1	SNW domain containing 1. (571 aa)
	BRCA2	BRCA2 DNA repair associated. (3419 aa)
	TOPORS	TOP1 binding arginine/serine rich protein. (1040 aa)
	BDKRB2	Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (393 aa)
	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (542 aa)
	E2F2	E2F transcription factor 2. (435 aa)
	PMAIP1	Uncharacterized protein. (54 aa)

Your Current Organism:

Propithecus coquereli

NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AEN	DDX5	ENSPCOP00000018109	ENSPCOP00000023201	Apoptosis enhancing nuclease.	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	0.477
AEN	PHLDA3	ENSPCOP00000018109	ENSPCOP00000003982	Apoptosis enhancing nuclease.	Pleckstrin homology like domain family A member 3.	0.541
AEN	RRP8	ENSPCOP00000018109	ENSPCOP00000024835	Apoptosis enhancing nuclease.	Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...]	0.530
ATAD5	BRCA2	ENSPCOP00000011601	ENSPCOP00000008219	ATPase family AAA domain containing 5.	BRCA2 DNA repair associated.	0.809
ATAD5	CHEK2	ENSPCOP00000011601	ENSPCOP00000026770	ATPase family AAA domain containing 5.	Checkpoint kinase 2.	0.676
ATAD5	MSH2	ENSPCOP00000011601	ENSPCOP00000005815	ATPase family AAA domain containing 5.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.565
BAX	BBC3	ENSPCOP00000019496	ENSPCOP00000016402	BCL2 associated X, apoptosis regulator.	BCL2 binding component 3.	0.902
BAX	CASP6	ENSPCOP00000019496	ENSPCOP00000011271	BCL2 associated X, apoptosis regulator.	Caspase 6; Belongs to the peptidase C14A family.	0.412
BAX	PMAIP1	ENSPCOP00000019496	ENSPCOP00000002848	BCL2 associated X, apoptosis regulator.	Uncharacterized protein.	0.796
BAX	SIRT1	ENSPCOP00000019496	ENSPCOP00000027970	BCL2 associated X, apoptosis regulator.	Sirtuin 1.	0.867
BAX	TP53	ENSPCOP00000019496	ENSPCOP00000031758	BCL2 associated X, apoptosis regulator.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.930
BAX	TP63	ENSPCOP00000019496	ENSPCOP00000030966	BCL2 associated X, apoptosis regulator.	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.674
BAX	TP73	ENSPCOP00000019496	ENSPCOP00000013117	BCL2 associated X, apoptosis regulator.	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.	0.674
BBC3	BAX	ENSPCOP00000016402	ENSPCOP00000019496	BCL2 binding component 3.	BCL2 associated X, apoptosis regulator.	0.902
BBC3	BOK	ENSPCOP00000016402	ENSPCOP00000004561	BCL2 binding component 3.	BCL2 family apoptosis regulator BOK.	0.862
BBC3	E2F1	ENSPCOP00000016402	ENSPCOP00000018203	BCL2 binding component 3.	E2F transcription factor 1.	0.402
BBC3	PMAIP1	ENSPCOP00000016402	ENSPCOP00000002848	BCL2 binding component 3.	Uncharacterized protein.	0.921
BBC3	TP53	ENSPCOP00000016402	ENSPCOP00000031758	BCL2 binding component 3.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.729
BBC3	TP63	ENSPCOP00000016402	ENSPCOP00000030966	BCL2 binding component 3.	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.549
BBC3	TP73	ENSPCOP00000016402	ENSPCOP00000013117	BCL2 binding component 3.	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.	0.549