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| | GLI3 | GLI family zinc finger 3. (1580 aa) |
| | MESP1 | Mesoderm posterior bHLH transcription factor 1. (261 aa) |
| | EGR1 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (543 aa) |
| | IGFBP2 | Insulin like growth factor binding protein 2. (321 aa) |
| | AMER2 | APC membrane recruitment protein 2. (550 aa) |
| | NOG | Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa) |
| | PRICKLE1 | Prickle planar cell polarity protein 1. (831 aa) |
| | SHISA6 | Shisa family member 6. (457 aa) |
| | TLE7 | TLE family member 7. (443 aa) |
| | STK11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (442 aa) |
| | HECW1 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1. (1600 aa) |
| | ZNRF3 | Zinc and ring finger 3. (900 aa) |
| | NOTCH1 | Notch receptor 1. (2420 aa) |
| | ENSPCOP00000004787 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (445 aa) |
| | IGFBP4 | Insulin like growth factor binding protein 4. (258 aa) |
| | TMEM170B | Transmembrane protein 170B. (132 aa) |
| | SIAH2 | E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (324 aa) |
| | MLLT3 | MLLT3 super elongation complex subunit. (569 aa) |
| | NOTUM | Notum, palmitoleoyl-protein carboxylesterase. (499 aa) |
| | TMEM131L | Transmembrane 131 like. (1607 aa) |
| | WNT11 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa) |
| | JADE1 | Jade family PHD finger 1. (843 aa) |
| | CDH2 | Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (906 aa) |
| | DKK3 | Dickkopf WNT signaling pathway inhibitor 3. (348 aa) |
| | CHD8 | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2592 aa) |
| | NPHP4 | Nephrocystin 4. (1427 aa) |
| | SOSTDC1 | Sclerostin domain containing 1. (229 aa) |
| | AXIN2 | Axin 2. (716 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa) |
| | DKKL1 | Dickkopf like acrosomal protein 1. (242 aa) |
| | MCC | MCC regulator of WNT signaling pathway. (825 aa) |
| | SOX17 | SRY-box transcription factor 17. (413 aa) |
| | FRZB | Frizzled related protein. (325 aa) |
| | SNAI2 | Snail family transcriptional repressor 2. (268 aa) |
| | MAD2L2 | Mitotic arrest deficient 2 like 2. (235 aa) |
| | EMD | Emerin. (260 aa) |
| | OTUD5 | OTU deubiquitinase 5. (590 aa) |
| | TBX18 | T-box transcription factor 18. (607 aa) |
| | LOC105819868 | Protein kinase domain-containing protein. (302 aa) |
| | ENSPCOP00000009621 | Uncharacterized protein. (500 aa) |
| | ENSPCOP00000009871 | TLE_N domain-containing protein. (179 aa) |
| | LOC105823019 | Uncharacterized protein. (87 aa) |
| | KREMEN1 | Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (458 aa) |
| | APOE | Apolipoprotein E. (314 aa) |
| | DDIT3 | DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa) |
| | DKK2 | Dickkopf WNT signaling pathway inhibitor 2. (259 aa) |
| | RBX1 | Ring-box 1. (108 aa) |
| | RBMS3 | RNA binding motif single stranded interacting protein 3. (435 aa) |
| | ENSPCOP00000011475 | Protein kinase domain-containing protein. (89 aa) |
| | TLE5 | TLE family member 5, transcriptional modulator. (251 aa) |
| | GLI1 | GLI family zinc finger 1. (1106 aa) |
| | DRAXIN | Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (349 aa) |
| | MDK | Midkine. (143 aa) |
| | FOXO1 | Forkhead box O1. (656 aa) |
| | TCF7L2 | Transcription factor 7 like 2. (619 aa) |
| | TLE1 | TLE family member 1, transcriptional corepressor. (774 aa) |
| | ISL1 | ISL LIM homeobox 1. (349 aa) |
| | GSK3A | Glycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (483 aa) |
| | LATS1 | Large tumor suppressor kinase 1. (1131 aa) |
| | SDHAF2 | Uncharacterized protein. (136 aa) |
| | STK4 | Serine/threonine kinase 4. (487 aa) |
| | FZD4 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa) |
| | TMEM88 | Transmembrane protein 88. (159 aa) |
| | ENSPCOP00000015405 | Uncharacterized protein. (113 aa) |
| | NKX2-5 | NK2 homeobox 5. (324 aa) |
| | FZD6 | Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa) |
| | CTHRC1 | Collagen triple helix repeat containing 1. (246 aa) |
| | CTNNBIP1 | Catenin beta interacting protein 1. (81 aa) |
| | UBAC2 | UBA domain containing 2. (345 aa) |
| | ENSPCOP00000016328 | Uncharacterized protein. (111 aa) |
| | AMER1 | APC membrane recruitment protein 1. (796 aa) |
| | PRKN | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (460 aa) |
| | SFRP5 | Secreted frizzled related protein 5. (315 aa) |
| | PFDN5 | Prefoldin subunit 5. (154 aa) |
| | ANKRD6 | Ankyrin repeat domain 6. (726 aa) |
| | MAPK14 | Mitogen-activated protein kinase 14. (340 aa) |
| | SFRP4 | Secreted frizzled related protein 4. (342 aa) |
| | SCYL2 | SCY1 like pseudokinase 2. (933 aa) |
| | SOX13 | SRY-box transcription factor 13. (615 aa) |
| | ENSPCOP00000018033 | HH_signal domain-containing protein. (110 aa) |
| | SFRP2 | Secreted frizzled related protein 2. (295 aa) |
| | NKD1 | NKD inhibitor of WNT signaling pathway 1. (471 aa) |
| | DKK4 | Dickkopf WNT signaling pathway inhibitor 4. (224 aa) |
| | TNN | Tenascin N. (1299 aa) |
| | DAB2IP | DAB2 interacting protein. (1209 aa) |
| | STK3 | Serine/threonine kinase 3. (500 aa) |
| | LMBR1L | Limb development membrane protein 1 like; Belongs to the LIMR family. (489 aa) |
| | WWTR1 | WW domain containing transcription regulator 1. (400 aa) |
| | TMEM64 | Transmembrane protein 64. (380 aa) |
| | DKK1 | Dickkopf WNT signaling pathway inhibitor 1. (268 aa) |
| | SOX10 | SRY-box transcription factor 10. (468 aa) |
| | AMFR | Autocrine motility factor receptor. (643 aa) |
| | CTNND1 | Catenin delta 1. (984 aa) |
| | DAB2 | DAB adaptor protein 2. (769 aa) |
| | SOST | Sclerostin. (213 aa) |
| | NKD2 | NKD inhibitor of WNT signaling pathway 2. (398 aa) |
| | TLE3 | TLE family member 3, transcriptional corepressor. (784 aa) |
| | LZTS2 | Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (671 aa) |
| | CTNNB1 | Catenin beta 1. (781 aa) |
| | TLE4 | TLE family member 4, transcriptional corepressor. (796 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (390 aa) |
| | APC2 | APC regulator of WNT signaling pathway 2. (2300 aa) |
| | DACT3 | Dishevelled binding antagonist of beta catenin 3. (631 aa) |
| | FERMT1 | Fermitin family member 1. (677 aa) |
| | LIMD1 | LIM domains containing 1. (672 aa) |
| | INVS | Inversin. (1008 aa) |
| | CAV1 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa) |
| | PTPRU | Protein tyrosine phosphatase receptor type U. (1446 aa) |
| | FUZ | Fuzzy planar cell polarity protein. (418 aa) |
| | RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (397 aa) |
| | ENSPCOP00000028788 | Uncharacterized protein. (171 aa) |
| | APC | APC regulator of WNT signaling pathway. (2844 aa) |
| | ENSPCOP00000028883 | Protein kinase domain-containing protein. (138 aa) |
| | LATS2 | Non-specific serine/threonine protein kinase. (1073 aa) |
| | SOX9 | SRY-box transcription factor 9. (505 aa) |
| | AXIN1 | Axin 1. (865 aa) |
| | FRMD8 | FERM domain containing 8. (465 aa) |
| | PTPRO | Protein tyrosine phosphatase receptor type O. (1031 aa) |
| | TLE6 | TLE family member 6, subcortical maternal complex member. (567 aa) |
| | SFRP1 | Secreted frizzled related protein 1. (314 aa) |
| | BMP2 | Bone morphogenetic protein 2. (395 aa) |
| | TLE2 | TLE family member 2, transcriptional corepressor. (737 aa) |
| | NPPA | Natriuretic peptide A. (153 aa) |
| | CYLD | CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa) |
| | IGFBP1 | Insulin like growth factor binding protein 1. (274 aa) |
| | BICC1 | BicC family RNA binding protein 1. (972 aa) |
| | LRP4 | LDL receptor related protein 4. (1922 aa) |
| | DACT1 | Dishevelled binding antagonist of beta catenin 1. (798 aa) |
