41 items (Propithecus coquereli) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	BNIP3	Uncharacterized protein. (235 aa)
	BIK	BCL2 interacting killer. (152 aa)
	PPIF	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (207 aa)
	TRIAP1	Uncharacterized protein. (76 aa)
	BMF	Bcl2 modifying factor. (184 aa)
	MMP9	Matrix metallopeptidase 9. (709 aa)
	GHITM	Growth hormone inducible transmembrane protein; Belongs to the BI1 family. (336 aa)
	FXN	Frataxin. (211 aa)
	PLA2G6	Phospholipase A2 group VI. (807 aa)
	BAK1	BCL2 antagonist/killer 1. (211 aa)
	ENSPCOP00000003708	Uncharacterized protein. (135 aa)
	PARL	Rhomboid domain-containing protein. (362 aa)
	CLU	Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (450 aa)
	CIDEB	Cell death inducing DFFA like effector b. (219 aa)
	PMAIP1	Uncharacterized protein. (54 aa)
	NOL3	Nucleolar protein 3. (204 aa)
	PSMD10	Proteasome 26S subunit, non-ATPase 10. (226 aa)
	PRKN	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (460 aa)
	BBC3	BCL2 binding component 3. (260 aa)
	PLSCR3	Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (295 aa)
	OPA1	OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (997 aa)
	HGF	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (703 aa)
	IGF1	Insulin like growth factor 1. (208 aa)
	AVP	Arginine vasopressin. (116 aa)
	BAX	BCL2 associated X, apoptosis regulator. (199 aa)
	PRELID1	PRELI domain containing 1. (219 aa)
	BCL2L1	BCL2 like 1. (233 aa)
	DNM1L	Dynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (749 aa)
	ENSPCOP00000021800	Uncharacterized protein. (175 aa)
	TNFSF10	Tumor necrosis factor ligand superfamily member. (288 aa)
	FAM162A	Family with sequence similarity 162 member A. (155 aa)
	ENSPCOP00000024369	Uncharacterized protein; Belongs to the intermediate filament family. (156 aa)
	BCL2L11	BCL2 like 11. (200 aa)
	PINK1	PTEN induced kinase 1. (581 aa)
	HRK	Harakiri, BCL2 interacting protein. (91 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	BAD	BCL2 associated agonist of cell death. (168 aa)
	LMNA	Lamin A/C; Belongs to the intermediate filament family. (665 aa)
	PYCARD	PYD and CARD domain containing. (195 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
	BID	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (220 aa)

Your Current Organism:

Propithecus coquereli

NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	BAD	ENSPCOP00000028969	ENSPCOP00000030712	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	BCL2 associated agonist of cell death.	0.986
AKT1	BAK1	ENSPCOP00000028969	ENSPCOP00000017183	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	BCL2 antagonist/killer 1.	0.465
AKT1	BAX	ENSPCOP00000028969	ENSPCOP00000019496	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	BCL2 associated X, apoptosis regulator.	0.557
AKT1	BCL2L1	ENSPCOP00000028969	ENSPCOP00000020737	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	BCL2 like 1.	0.937
AKT1	BCL2L11	ENSPCOP00000028969	ENSPCOP00000024486	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	BCL2 like 11.	0.523
AKT1	DNM1L	ENSPCOP00000028969	ENSPCOP00000020866	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Dynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.406
AKT1	ENSPCOP00000024369	ENSPCOP00000028969	ENSPCOP00000024369	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the intermediate filament family.	0.451
AKT1	HGF	ENSPCOP00000028969	ENSPCOP00000018290	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.629
AKT1	LMNA	ENSPCOP00000028969	ENSPCOP00000030983	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Lamin A/C; Belongs to the intermediate filament family.	0.451
AKT1	MMP9	ENSPCOP00000028969	ENSPCOP00000012285	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Matrix metallopeptidase 9.	0.536
AKT1	PRKN	ENSPCOP00000028969	ENSPCOP00000016451	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.550
AKT1	TNFSF10	ENSPCOP00000028969	ENSPCOP00000023913	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tumor necrosis factor ligand superfamily member.	0.512
AKT1	TP53	ENSPCOP00000028969	ENSPCOP00000031758	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.937
BAD	AKT1	ENSPCOP00000030712	ENSPCOP00000028969	BCL2 associated agonist of cell death.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.986
BAD	BAK1	ENSPCOP00000030712	ENSPCOP00000017183	BCL2 associated agonist of cell death.	BCL2 antagonist/killer 1.	0.929
BAD	BAX	ENSPCOP00000030712	ENSPCOP00000019496	BCL2 associated agonist of cell death.	BCL2 associated X, apoptosis regulator.	0.924
BAD	BCL2L1	ENSPCOP00000030712	ENSPCOP00000020737	BCL2 associated agonist of cell death.	BCL2 like 1.	0.999
BAD	BCL2L11	ENSPCOP00000030712	ENSPCOP00000024486	BCL2 associated agonist of cell death.	BCL2 like 11.	0.809
BAD	BID	ENSPCOP00000030712	ENSPCOP00000032104	BCL2 associated agonist of cell death.	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	0.702
BAK1	AKT1	ENSPCOP00000017183	ENSPCOP00000028969	BCL2 antagonist/killer 1.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.465