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ENSPCOP00000025432 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (747 aa) | ||||
ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (298 aa) | ||||
ENSPCOP00000002776 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (330 aa) | ||||
ROMO1 | Reactive oxygen species modulator 1. (79 aa) | ||||
MME | Membrane metalloendopeptidase. (750 aa) | ||||
WNT16 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) | ||||
SERPINE1 | Serpin family E member 1; Belongs to the serpin family. (402 aa) | ||||
ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2643 aa) | ||||
CHEK1 | Checkpoint kinase 1. (454 aa) | ||||
ATM | ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2635 aa) | ||||
PLA2R1 | Phospholipase A2 receptor 1. (1403 aa) | ||||
CDKN2A | Cyclin dependent kinase inhibitor 2A. (152 aa) | ||||
CHEK2 | Checkpoint kinase 2. (571 aa) | ||||
CTC1 | CST telomere replication complex component 1. (1221 aa) | ||||
TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa) |