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| | BNIP3 | Uncharacterized protein. (235 aa) |
| | JMY | Junction mediating and regulatory protein, p53 cofactor. (935 aa) |
| | ENSPCOP00000014340 | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (468 aa) |
| | MYBBP1A | MYB binding protein 1a. (1342 aa) |
| | ERO1A | Endoplasmic reticulum oxidoreductase 1 alpha. (385 aa) |
| | PPP1R13B | Protein phosphatase 1 regulatory subunit 13B. (1088 aa) |
| | BDKRB2 | Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (393 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (868 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4130 aa) |
| | ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1488 aa) |
| | ENSPCOP00000006834 | Uncharacterized protein. (78 aa) |
| | PPM1F | Protein phosphatase, Mg2+/Mn2+ dependent 1F. (444 aa) |
| | MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1229 aa) |
| | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (542 aa) |
| | TRIB3 | Tribbles pseudokinase 3. (367 aa) |
| | ENSPCOP00000000775 | LIM zinc-binding domain-containing protein. (77 aa) |
| | E2F2 | E2F transcription factor 2. (435 aa) |
| | USP47 | Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1376 aa) |
| | SFN | Stratifin; Belongs to the 14-3-3 family. (248 aa) |
| | PDX1 | Pancreatic and duodenal homeobox 1. (282 aa) |
| | BCL2A1 | BCL2 related protein A1. (173 aa) |
| | NOL3 | Nucleolar protein 3. (204 aa) |
| | MAEL | Maelstrom spermatogenic transposon silencer. (434 aa) |
| | SGPP1 | Sphingosine-1-phosphate phosphatase 1. (441 aa) |
| | PMAIP1 | Uncharacterized protein. (54 aa) |
| | CIDEB | Cell death inducing DFFA like effector b. (219 aa) |
| | CLU | Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (450 aa) |
| | PDK1 | Protein-serine/threonine kinase. (438 aa) |
| | AIFM1 | Apoptosis inducing factor mitochondria associated 1. (613 aa) |
| | LOC105808398 | Bis(5'-adenosyl)-triphosphatase. (148 aa) |
| | STK11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (442 aa) |
| | CUL3 | Cullin 3; Belongs to the cullin family. (734 aa) |
| | ENSPCOP00000003784 | Na_trans_assoc domain-containing protein. (129 aa) |
| | HIPK2 | Homeodomain interacting protein kinase 2. (1187 aa) |
| | POU4F2 | POU domain protein. (408 aa) |
| | SKIL | SKI like proto-oncogene. (664 aa) |
| | PHLDA3 | Pleckstrin homology like domain family A member 3. (125 aa) |
| | MLH1 | MutL homolog 1. (757 aa) |
| | BOK | BCL2 family apoptosis regulator BOK. (213 aa) |
| | SHISA5 | Shisa family member 5. (239 aa) |
| | BAG6 | BCL2 associated athanogene 6. (1124 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (393 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | BCL3 | BCL3 transcription coactivator. (454 aa) |
| | E2F1 | E2F transcription factor 1. (436 aa) |
| | AEN | Apoptosis enhancing nuclease. (325 aa) |
| | ATF4 | Activating transcription factor 4. (351 aa) |
| | CASP7 | Caspase 7; Belongs to the peptidase C14A family. (341 aa) |
| | ENSPCOP00000017775 | PRA1 family protein. (83 aa) |
| | ATM | ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2635 aa) |
| | APAF1 | Apoptotic peptidase activating factor 1. (1204 aa) |
| | BAK1 | BCL2 antagonist/killer 1. (211 aa) |
| | ZNF622 | Zinc finger protein 622. (473 aa) |
| | CASP2 | Caspase 2; Belongs to the peptidase C14A family. (452 aa) |
| | BBC3 | BCL2 binding component 3. (260 aa) |
| | MELK | Non-specific serine/threonine protein kinase. (493 aa) |
| | DDIT4 | DNA damage inducible transcript 4. (230 aa) |
| | EP300 | E1A binding protein p300. (2424 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (199 aa) |
| | DAB2IP | DAB2 interacting protein. (1209 aa) |
| | ENSPCOP00000019967 | Uncharacterized protein. (713 aa) |
| | CHAC1 | Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (264 aa) |
| | PML | Promyelocytic leukemia. (887 aa) |
| | BCL2L1 | BCL2 like 1. (233 aa) |
| | BCL2 | BCL2 apoptosis regulator. (234 aa) |
| | PPP1R15A | Protein phosphatase 1 regulatory subunit 15A. (633 aa) |
| | ENSPCOP00000021345 | BTB domain-containing protein. (236 aa) |
| | PERP | P53 apoptosis effector related to PMP22. (193 aa) |
| | ENSPCOP00000021800 | Uncharacterized protein. (175 aa) |
| | DYRK2 | Dual specificity tyrosine phosphorylation regulated kinase 2. (601 aa) |
| | CYP1B1 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa) |
| | STK24 | Serine/threonine kinase 24. (443 aa) |
| | COA8 | Cytochrome c oxidase assembly factor 8. (206 aa) |
| | CUL4A | Cullin 4A; Belongs to the cullin family. (671 aa) |
| | STK25 | Serine/threonine kinase 25. (426 aa) |
| | ERN1 | Endoplasmic reticulum to nucleus signaling 1. (935 aa) |
| | HTRA2 | HtrA serine peptidase 2. (458 aa) |
| | DDX5 | DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa) |
| | FLCN | Folliculin. (579 aa) |
| | ENSPCOP00000023392 | Uncharacterized protein. (157 aa) |
| | HIC1 | HIC ZBTB transcriptional repressor 1. (732 aa) |
| | WWOX | WW domain containing oxidoreductase. (414 aa) |
| | PDK2 | Protein-serine/threonine kinase. (407 aa) |
| | BCL2L11 | BCL2 like 11. (200 aa) |
| | ZNF385B | Zinc finger protein 385B. (471 aa) |
| | POU4F1 | POU domain protein. (421 aa) |
| | RRP8 | Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (454 aa) |
| | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1. (2732 aa) |
| | TMEM117 | Transmembrane protein 117. (514 aa) |
| | MCL1 | MCL1 apoptosis regulator, BCL2 family member. (350 aa) |
| | TNFRSF1B | TNF receptor superfamily member 1B. (449 aa) |
| | USP28 | Ubiquitin specific peptidase 28; Belongs to the peptidase C19 family. (1061 aa) |
| | FNIP2 | Folliculin interacting protein 2. (1114 aa) |
| | TP73 | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (588 aa) |
| | ATP2A3 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1033 aa) |
| | ENSPCOP00000012342 | RING-type domain-containing protein. (80 aa) |
| | ENSPCOP00000012261 | Uncharacterized protein. (74 aa) |
| | ERN2 | Endoplasmic reticulum to nucleus signaling 2. (905 aa) |
| | LOC105810428 | Uncharacterized protein. (274 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1646 aa) |
| | CASP6 | Caspase 6; Belongs to the peptidase C14A family. (293 aa) |
| | SIVA1 | Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (175 aa) |
| | LOC105818856 | Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (600 aa) |
| | DDIT3 | DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa) |
| | EPHA2 | EPH receptor A2. (976 aa) |
| | ENSPCOP00000009641 | Uncharacterized protein. (136 aa) |
| | SELENOK | Selenoprotein K. (91 aa) |
| | EDA2R | Ectodysplasin A2 receptor. (314 aa) |
| | CDIP1 | Cell death inducing p53 target 1. (208 aa) |
| | NFATC4 | Nuclear factor of activated T cells 4. (953 aa) |
| | ENSPCOP00000009093 | Uncharacterized protein. (88 aa) |
| | TMEM109 | Transmembrane protein 109. (243 aa) |
| | SNW1 | SNW domain containing 1. (571 aa) |
| | MAP3K5 | Mitogen-activated protein kinase kinase kinase 5. (1317 aa) |
| | IFI6 | Interferon alpha inducible protein 6. (131 aa) |
| | TNF | Tumor necrosis factor; Belongs to the tumor necrosis factor family. (235 aa) |
| | BCL2L10 | Uncharacterized protein. (192 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa) |
| | PYCARD | PYD and CARD domain containing. (195 aa) |
| | GSKIP | GSK3B interacting protein. (139 aa) |
| | TP63 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa) |
| | QRICH1 | Glutamine rich 1. (775 aa) |
| | BAD | BCL2 associated agonist of cell death. (168 aa) |
| | NOX1 | NADPH oxidase 1. (564 aa) |
| | LGALS12 | Galectin. (275 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (406 aa) |
| | BRSK2 | BR serine/threonine kinase 2. (721 aa) |
| | PDCD10 | Programmed cell death 10. (186 aa) |
| | CEBPB | CCAAT/enhancer-binding protein. (347 aa) |
| | HIPK1 | Homeodomain interacting protein kinase 1. (1131 aa) |
| | SIRT1 | Sirtuin 1. (743 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3419 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa) |
| | ENSPCOP00000027819 | Uncharacterized protein. (200 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (447 aa) |
| | ENSPCOP00000027261 | Uncharacterized protein. (113 aa) |
| | POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (333 aa) |
| | CHEK2 | Checkpoint kinase 2. (571 aa) |
| | PRKCD | Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) |
| | TOPORS | TOP1 binding arginine/serine rich protein. (1040 aa) |
| | ELL3 | Elongation factor for RNA polymerase II 3. (396 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa) |
