(34 nodes) Postsynaptic signal transduction network (Propithecus coquereli)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CRKL	CRK like proto-oncogene, adaptor protein. (303 aa)
	LYPD1	LY6/PLAUR domain containing 1. (141 aa)
	CHRNB2	Cholinergic receptor nicotinic beta 2 subunit. (502 aa)
	CHRNA1	Cholinergic receptor nicotinic alpha 1 subunit. (479 aa)
	CHRND	Cholinergic receptor nicotinic delta subunit. (517 aa)
	RNF10	Ring finger protein 10. (807 aa)
	CHRNG	Cholinergic receptor nicotinic gamma subunit. (519 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	LY6G6D	Lymphocyte antigen 6 family member G6D. (133 aa)
	HRH3	Histamine receptor H3; Belongs to the G-protein coupled receptor 1 family. (452 aa)
	GRK2	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (689 aa)
	CRTC1	CREB regulated transcription coactivator 1. (650 aa)
	GNAI2	G protein subunit alpha i2. (355 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (551 aa)
	ACHE	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (615 aa)
	RGS10	Regulator of G protein signaling 10. (181 aa)
	OPRM1	Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. (479 aa)
	RGS8	Regulator of G protein signaling 8. (198 aa)
	ENSPCOP00000011918	Uncharacterized protein. (101 aa)
	CHRNB1	Cholinergic receptor nicotinic beta 1 subunit. (502 aa)
	NRG1	Neuregulin 1. (710 aa)
	SLURP2	Secreted LY6/PLAUR domain containing 2. (98 aa)
	LOC105812100	IBB domain-containing protein. (387 aa)
	AGRN	Agrin. (2040 aa)
	PRR7	Proline rich 7, synaptic. (276 aa)
	GNA15	G protein subunit alpha 15. (374 aa)
	PLCB1	Phosphoinositide phospholipase C. (1010 aa)
	CHRM1	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (460 aa)
	KPNA2	Importin subunit alpha; Functions in nuclear protein import. (479 aa)
	CHRM2	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (466 aa)
	KPNA1	Importin subunit alpha; Functions in nuclear protein import. (538 aa)
	CDK5R1	Cyclin-dependent kinase 5 activator. (306 aa)
	CHRNA3	Cholinergic receptor nicotinic alpha 3 subunit. (500 aa)
	LY6H	Lymphocyte antigen 6 family member H. (161 aa)

Your Current Organism:

Propithecus coquereli

NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACHE	AGRN	ENSPCOP00000016659	ENSPCOP00000007079	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	Agrin.	0.616
ACHE	CHRND	ENSPCOP00000016659	ENSPCOP00000018881	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	Cholinergic receptor nicotinic delta subunit.	0.417
AGRN	ACHE	ENSPCOP00000007079	ENSPCOP00000016659	Agrin.	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	0.616
AGRN	CHRND	ENSPCOP00000007079	ENSPCOP00000018881	Agrin.	Cholinergic receptor nicotinic delta subunit.	0.586
CHRM1	CHRM2	ENSPCOP00000004850	ENSPCOP00000002774	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	0.854
CHRM1	CHRNB2	ENSPCOP00000004850	ENSPCOP00000017480	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	Cholinergic receptor nicotinic beta 2 subunit.	0.418
CHRM1	GNA15	ENSPCOP00000004850	ENSPCOP00000005702	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	G protein subunit alpha 15.	0.900
CHRM1	GNAI2	ENSPCOP00000004850	ENSPCOP00000030255	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	G protein subunit alpha i2.	0.879
CHRM1	GRK2	ENSPCOP00000004850	ENSPCOP00000028447	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.601
CHRM1	HRH3	ENSPCOP00000004850	ENSPCOP00000028264	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	Histamine receptor H3; Belongs to the G-protein coupled receptor 1 family.	0.740
CHRM1	PLCB1	ENSPCOP00000004850	ENSPCOP00000005605	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	Phosphoinositide phospholipase C.	0.613
CHRM2	CHRM1	ENSPCOP00000002774	ENSPCOP00000004850	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	0.854
CHRM2	GNA15	ENSPCOP00000002774	ENSPCOP00000005702	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	G protein subunit alpha 15.	0.900
CHRM2	GNAI2	ENSPCOP00000002774	ENSPCOP00000030255	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	G protein subunit alpha i2.	0.884
CHRM2	GRK2	ENSPCOP00000002774	ENSPCOP00000028447	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.472
CHRM2	HRH3	ENSPCOP00000002774	ENSPCOP00000028264	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	Histamine receptor H3; Belongs to the G-protein coupled receptor 1 family.	0.787
CHRM2	PLCB1	ENSPCOP00000002774	ENSPCOP00000005605	Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.	Phosphoinositide phospholipase C.	0.450
CHRNA1	CHRNA3	ENSPCOP00000017659	ENSPCOP00000000424	Cholinergic receptor nicotinic alpha 1 subunit.	Cholinergic receptor nicotinic alpha 3 subunit.	0.907
CHRNA1	CHRNB1	ENSPCOP00000017659	ENSPCOP00000011398	Cholinergic receptor nicotinic alpha 1 subunit.	Cholinergic receptor nicotinic beta 1 subunit.	0.954
CHRNA1	CHRNB2	ENSPCOP00000017659	ENSPCOP00000017480	Cholinergic receptor nicotinic alpha 1 subunit.	Cholinergic receptor nicotinic beta 2 subunit.	0.916