STRINGSTRING
IGF1 IGF1 MEF2D MEF2D GJA1 GJA1 NF1 NF1 ENSPCOP00000025432 ENSPCOP00000025432 ERN1 ERN1 LDLRAP1 LDLRAP1 FRS2 FRS2 DDR2 DDR2 SRC SRC ADAMTS1 ADAMTS1 MAP3K5 MAP3K5 TNF TNF DNMT1 DNMT1 MMP9 MMP9 BMPR1A BMPR1A MMP2 MMP2 FGF9 FGF9 CALCRL CALCRL NR4A3 NR4A3 XBP1 XBP1 MFN2 MFN2 PDGFB PDGFB ENSPCOP00000002776 ENSPCOP00000002776 FOXJ2 FOXJ2 IGFBP5 IGFBP5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IGF1Insulin like growth factor 1. (208 aa)
MEF2DMyocyte enhancer factor 2D. (519 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
NF1Neurofibromin 1. (2841 aa)
ENSPCOP00000025432Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (747 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (935 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (308 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
SRCTyrosine-protein kinase. (543 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (965 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1317 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (235 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1615 aa)
MMP9Matrix metallopeptidase 9. (709 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (484 aa)
MMP2Matrix metallopeptidase 2. (552 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
CALCRLCalcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family. (372 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (645 aa)
XBP1BZIP domain-containing protein. (377 aa)
MFN2Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
ENSPCOP00000002776Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (330 aa)
FOXJ2Forkhead box J2. (527 aa)
IGFBP5Insulin like growth factor binding protein 5. (272 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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