node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BMPR1A | GJA1 | ENSPCOP00000011972 | ENSPCOP00000028376 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. | 0.442 |
ENSPCOP00000002776 | ENSPCOP00000025432 | ENSPCOP00000002776 | ENSPCOP00000025432 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | 0.942 |
ENSPCOP00000025432 | ENSPCOP00000002776 | ENSPCOP00000025432 | ENSPCOP00000002776 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | 0.942 |
ERN1 | GJA1 | ENSPCOP00000022887 | ENSPCOP00000028376 | Endoplasmic reticulum to nucleus signaling 1. | Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. | 0.433 |
ERN1 | MAP3K5 | ENSPCOP00000022887 | ENSPCOP00000015848 | Endoplasmic reticulum to nucleus signaling 1. | Mitogen-activated protein kinase kinase kinase 5. | 0.980 |
ERN1 | MFN2 | ENSPCOP00000022887 | ENSPCOP00000003527 | Endoplasmic reticulum to nucleus signaling 1. | Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | 0.444 |
ERN1 | TNF | ENSPCOP00000022887 | ENSPCOP00000015346 | Endoplasmic reticulum to nucleus signaling 1. | Tumor necrosis factor; Belongs to the tumor necrosis factor family. | 0.693 |
ERN1 | XBP1 | ENSPCOP00000022887 | ENSPCOP00000003952 | Endoplasmic reticulum to nucleus signaling 1. | BZIP domain-containing protein. | 0.938 |
FGF9 | FRS2 | ENSPCOP00000006171 | ENSPCOP00000019145 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Fibroblast growth factor receptor substrate 2. | 0.686 |
FGF9 | PDGFB | ENSPCOP00000006171 | ENSPCOP00000003339 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. | 0.438 |
FOXJ2 | NF1 | ENSPCOP00000001755 | ENSPCOP00000026338 | Forkhead box J2. | Neurofibromin 1. | 0.597 |
FRS2 | FGF9 | ENSPCOP00000019145 | ENSPCOP00000006171 | Fibroblast growth factor receptor substrate 2. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.686 |
FRS2 | SRC | ENSPCOP00000019145 | ENSPCOP00000018583 | Fibroblast growth factor receptor substrate 2. | Tyrosine-protein kinase. | 0.723 |
GJA1 | BMPR1A | ENSPCOP00000028376 | ENSPCOP00000011972 | Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | 0.442 |
GJA1 | ERN1 | ENSPCOP00000028376 | ENSPCOP00000022887 | Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. | Endoplasmic reticulum to nucleus signaling 1. | 0.433 |
GJA1 | MFN2 | ENSPCOP00000028376 | ENSPCOP00000003527 | Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. | Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | 0.462 |
GJA1 | SRC | ENSPCOP00000028376 | ENSPCOP00000018583 | Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. | Tyrosine-protein kinase. | 0.899 |
IGF1 | IGFBP5 | ENSPCOP00000019178 | ENSPCOP00000000553 | Insulin like growth factor 1. | Insulin like growth factor binding protein 5. | 0.845 |
IGF1 | PDGFB | ENSPCOP00000019178 | ENSPCOP00000003339 | Insulin like growth factor 1. | Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. | 0.895 |
IGFBP5 | IGF1 | ENSPCOP00000000553 | ENSPCOP00000019178 | Insulin like growth factor binding protein 5. | Insulin like growth factor 1. | 0.845 |