STRINGSTRING
STK17A STK17A TGFB1 TGFB1 MMP3 MMP3 GADD45A GADD45A COA8 COA8 ENSPCOP00000006829 ENSPCOP00000006829 PLIN5 PLIN5 EIF6 EIF6 ITGB2 ITGB2 XDH XDH FYN FYN ATG5 ATG5 RAB27A RAB27A ZC3H12A ZC3H12A LOC105819868 LOC105819868 SYK SYK DCXR DCXR CD36 CD36 ABCD1 ABCD1 PID1 PID1 FOXM1 FOXM1 SIRT2 SIRT2 PPARA PPARA PLCG2 PLCG2 ABCB7 ABCB7 ENSPCOP00000012342 ENSPCOP00000012342 FOXO1 FOXO1 HK2 HK2 SLC25A33 SLC25A33 ENSPCOP00000013232 ENSPCOP00000013232 F2 F2 SLC30A10 SLC30A10 ZNF205 ZNF205 TSPO TSPO MPV17 MPV17 BNIP3 BNIP3 TNF TNF PAX2 PAX2 ALOX5 ALOX5 ENSPCOP00000015642 ENSPCOP00000015642 PRKN PRKN BCR BCR UCP1 UCP1 MPV17L MPV17L MAPK14 MAPK14 GRB2 GRB2 TFAP2A TFAP2A TRAP1 TRAP1 ABCD2 ABCD2 VDAC1 VDAC1 PIKFYVE PIKFYVE TP53 TP53 G6PD G6PD RIPK3 RIPK3 CTNS CTNS ACOD1 ACOD1 PDGFRB PDGFRB TUSC2 TUSC2 HDAC6 HDAC6 BST1 BST1 CCN3 CCN3 AATF AATF GRIN1 GRIN1 PDK3 PDK3 BCL2 BCL2 PARK7 PARK7 PON3 PON3 DUOXA1 DUOXA1 PTK2B PTK2B HVCN1 HVCN1 PRKCD PRKCD DUOXA2 DUOXA2 CCN6 CCN6 CLEC7A CLEC7A THBS1 THBS1 SLC18A2 SLC18A2 PINK1 PINK1 ENSPCOP00000024480 ENSPCOP00000024480 RIPK1 RIPK1 CYBA CYBA ENSPCOP00000021800 ENSPCOP00000021800 CYP1B1 CYP1B1 ENSPCOP00000023392 ENSPCOP00000023392 PON2 PON2 CD177 CD177 COQ7 COQ7 GCH1 GCH1 NFE2L2 NFE2L2 SIRT5 SIRT5 ENSPCOP00000003159 ENSPCOP00000003159 TIGAR TIGAR PDGFB PDGFB PARL PARL MT3 MT3 BMP7 BMP7 ARG2 ARG2 SPHK2 SPHK2 MMP8 MMP8 RNF41 RNF41 TGFBR2 TGFBR2 LOC105825287 LOC105825287 HIF1A HIF1A ACP5 ACP5 ROMO1 ROMO1 CRP CRP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STK17ASerine/threonine kinase 17a; Belongs to the protein kinase superfamily. (411 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
MMP3Matrix metallopeptidase 3. (477 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
COA8Cytochrome c oxidase assembly factor 8. (206 aa)
ENSPCOP00000006829Uncharacterized protein. (252 aa)
PLIN5Perilipin; Belongs to the perilipin family. (450 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (291 aa)
ITGB2Integrin beta. (764 aa)
XDHXanthine dehydrogenase. (1313 aa)
FYNTyrosine-protein kinase. (537 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
RAB27ARAB27A, member RAS oncogene family. (221 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (598 aa)
LOC105819868Protein kinase domain-containing protein. (302 aa)
SYKSpleen associated tyrosine kinase. (637 aa)
DCXRDicarbonyl and L-xylulose reductase. (226 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
ABCD1ATP binding cassette subfamily D member 1. (746 aa)
PID1Phosphotyrosine interaction domain containing 1. (248 aa)
FOXM1Forkhead box M1. (763 aa)
SIRT2Sirtuin 2. (469 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1233 aa)
ABCB7ATP binding cassette subfamily B member 7. (655 aa)
ENSPCOP00000012342RING-type domain-containing protein. (80 aa)
FOXO1Forkhead box O1. (656 aa)
HK2Hexokinase 2. (841 aa)
SLC25A33Solute carrier family 25 member 33; Belongs to the mitochondrial carrier (TC 2.A.29) family. (321 aa)
ENSPCOP00000013232Protein-serine/threonine kinase. (359 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
SLC30A10Solute carrier family 30 member 10. (486 aa)
ZNF205Zinc finger protein 205. (552 aa)
TSPOTranslocator protein. (169 aa)
MPV17Mitochondrial inner membrane protein MPV17; Belongs to the peroxisomal membrane protein PXMP2/4 family. (176 aa)
BNIP3Uncharacterized protein. (235 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (235 aa)
PAX2Paired box 2. (417 aa)
ALOX5Arachidonate 5-lipoxygenase. (675 aa)
ENSPCOP00000015642DJ-1_PfpI domain-containing protein. (175 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (460 aa)
BCRBCR activator of RhoGEF and GTPase. (1168 aa)
UCP1Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (306 aa)
MPV17LUncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family. (196 aa)
MAPK14Mitogen-activated protein kinase 14. (340 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
TFAP2ATranscription factor AP-2 alpha. (439 aa)
TRAP1TNF receptor associated protein 1. (681 aa)
ABCD2ATP binding cassette subfamily D member 2. (740 aa)
VDAC1Uncharacterized protein. (283 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2053 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
G6PDGlucose-6-phosphate dehydrogenase. (558 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (516 aa)
CTNSCystinosin, lysosomal cystine transporter. (387 aa)
ACOD1Aconitate decarboxylase 1. (478 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1105 aa)
TUSC2Tumor suppressor 2, mitochondrial calcium regulator. (110 aa)
HDAC6Histone deacetylase 6. (1203 aa)
BST1Bone marrow stromal cell antigen 1. (329 aa)
CCN3Cellular communication network factor 3. (297 aa)
AATFApoptosis antagonizing transcription factor. (567 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (960 aa)
PDK3Protein-serine/threonine kinase. (352 aa)
BCL2BCL2 apoptosis regulator. (234 aa)
PARK7DJ-1_PfpI domain-containing protein. (155 aa)
PON3Paraoxonase 3. (354 aa)
DUOXA1Dual oxidase maturation factor 1. (342 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (967 aa)
HVCN1Hydrogen voltage gated channel 1. (271 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
DUOXA2Dual oxidase maturation factor 2. (320 aa)
CCN6CTCK domain-containing protein. (130 aa)
CLEC7AUncharacterized protein. (62 aa)
THBS1Thrombospondin 1. (1185 aa)
SLC18A2Solute carrier family 18 member A2. (491 aa)
PINK1PTEN induced kinase 1. (581 aa)
ENSPCOP00000024480Uncharacterized protein. (103 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (643 aa)
CYBACytochrome b-245 alpha chain. (129 aa)
ENSPCOP00000021800Uncharacterized protein. (175 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa)
ENSPCOP00000023392Uncharacterized protein. (157 aa)
PON2Paraoxonase 2. (375 aa)
CD177CD177 molecule. (439 aa)
COQ7Coenzyme Q7, hydroxylase. (178 aa)
GCH1GTP cyclohydrolase 1. (250 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (606 aa)
SIRT5NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] (313 aa)
ENSPCOP00000003159IGFBP N-terminal domain-containing protein. (230 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
PARLRhomboid domain-containing protein. (362 aa)
MT3Metallothionein 3; Belongs to the metallothionein superfamily. Type 1 family. (114 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
ARG2Arginase. (354 aa)
SPHK2Sphingosine kinase 2. (660 aa)
MMP8Matrix metallopeptidase 8. (466 aa)
RNF41Ring finger protein 41. (317 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
LOC105825287DJ-1_PfpI domain-containing protein. (189 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (325 aa)
ROMO1Reactive oxygen species modulator 1. (79 aa)
CRPPentaxin. (225 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.