STRINGSTRING
ZNF512 ZNF512 FOS FOS TENT2 TENT2 EGR1 EGR1 APLN APLN TGFB2 TGFB2 NFATC3 NFATC3 SMAD6 SMAD6 GATA2 GATA2 ENSPCOP00000002776 ENSPCOP00000002776 PDGFB PDGFB MYC MYC HIF1A HIF1A SMAD1 SMAD1 ZNF512B ZNF512B IL10 IL10 NFKB1 NFKB1 PNPT1 PNPT1 ENSPCOP00000008878 ENSPCOP00000008878 KLF4 KLF4 ZC3H12A ZC3H12A GATA3 GATA3 NFATC4 NFATC4 KLF5 KLF5 LIN28B LIN28B NFIB NFIB PPARA PPARA BMPR1A BMPR1A MYB MYB MRTFA MRTFA NGFR NGFR ENSPCOP00000014590 ENSPCOP00000014590 ZSWIM8 ZSWIM8 TNF TNF MRTFB MRTFB PRL PRL WT1 WT1 RC3H1 RC3H1 SRF SRF ATOH8 ATOH8 SMAD3 SMAD3 SMARCA4 SMARCA4 SREBF2 SREBF2 TGFB1 TGFB1 RARA RARA SREBF1 SREBF1 SMAD4 SMAD4 ENSPCOP00000025432 ENSPCOP00000025432 TEAD1 TEAD1 REST REST GATA6 GATA6 GNL3 GNL3 BMP4 BMP4 NR1H2 NR1H2 SOX9 SOX9 FOSL1 FOSL1 KHSRP KHSRP STAT3 STAT3 PPARD PPARD BMP2 BMP2 MYOCD MYOCD ENSPCOP00000031233 ENSPCOP00000031233 DROSHA DROSHA TP53 TP53 ETS1 ETS1 RC3H2 RC3H2 RELA RELA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZNF512Zinc finger protein 512. (557 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (381 aa)
TENT2Terminal nucleotidyltransferase 2. (411 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (543 aa)
APLNApelin. (77 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
NFATC3Nuclear factor of activated T cells 3. (1075 aa)
SMAD6Mothers against decapentaplegic homolog. (500 aa)
GATA2GATA binding protein 2. (445 aa)
ENSPCOP00000002776Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (330 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (453 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
ZNF512BZinc finger protein 512B. (892 aa)
IL10Interleukin 10. (178 aa)
NFKB1Nuclear factor kappa B subunit 1. (961 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1. (672 aa)
ENSPCOP00000008878Uncharacterized protein. (329 aa)
KLF4Uncharacterized protein. (486 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (598 aa)
GATA3Uncharacterized protein. (444 aa)
NFATC4Nuclear factor of activated T cells 4. (953 aa)
KLF5Kruppel like factor 5. (457 aa)
LIN28BLin-28 homolog B. (258 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (484 aa)
MYBMYB proto-oncogene, transcription factor. (760 aa)
MRTFAMyocardin related transcription factor A. (968 aa)
NGFRNerve growth factor receptor. (429 aa)
ENSPCOP00000014590Uncharacterized protein. (118 aa)
ZSWIM8Zinc finger SWIM-type containing 8. (1892 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (235 aa)
MRTFBMyocardin related transcription factor B. (1102 aa)
PRLProlactin. (231 aa)
WT1WT1 transcription factor. (522 aa)
RC3H1Ring finger and CCCH-type domains 1. (975 aa)
SRFSerum response factor. (508 aa)
ATOH8Atonal bHLH transcription factor 8. (313 aa)
SMAD3Mothers against decapentaplegic homolog. (443 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1661 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1133 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
RARARetinoic acid receptor alpha. (472 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1180 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ENSPCOP00000025432Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (747 aa)
TEAD1TEA domain transcription factor 1. (434 aa)
RESTUncharacterized protein. (1018 aa)
GATA6GATA binding protein 6. (593 aa)
GNL3G protein nucleolar 3. (549 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (459 aa)
SOX9SRY-box transcription factor 9. (505 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (272 aa)
KHSRPKH-type splicing regulatory protein. (653 aa)
STAT3Signal transducer and activator of transcription. (796 aa)
PPARDPeroxisome proliferator activated receptor delta. (440 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
MYOCDMyocardin. (780 aa)
ENSPCOP00000031233Uncharacterized protein. (318 aa)
DROSHADrosha ribonuclease III. (1354 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
RC3H2Ring finger and CCCH-type domains 2. (1183 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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