STRINGSTRING
KDR KDR KDM1A KDM1A KAT7 KAT7 ENSPCOP00000020151 ENSPCOP00000020151 ENSPCOP00000019705 ENSPCOP00000019705 LTBP3 LTBP3 HMX2 HMX2 LOC105808476 LOC105808476 ENSPCOP00000026834 ENSPCOP00000026834 HOXA3 HOXA3 ELL3 ELL3 ENSPCOP00000025432 ENSPCOP00000025432 ENSPCOP00000025005 ENSPCOP00000025005 TGFB1 TGFB1 CTNNB1 CTNNB1 KITLG KITLG VEGFC VEGFC SHOX2 SHOX2 SIRT6 SIRT6 FGF4 FGF4 TP63 TP63 SOX11 SOX11 SOX9 SOX9 GJA1 GJA1 CCNE1 CCNE1 HMGA2 HMGA2 FGF10 FGF10 LOC105820095 LOC105820095 WNT10B WNT10B ENSPCOP00000002776 ENSPCOP00000002776 CITED1 CITED1 ENSPCOP00000005396 ENSPCOP00000005396 FGF9 FGF9 PRRX1 PRRX1 PDCD2 PDCD2 WNT5A WNT5A WNT1 WNT1 EPCAM EPCAM YAP1 YAP1 FERMT2 FERMT2 FGF8 FGF8 HNRNPU HNRNPU ID4 ID4 TIAL1 TIAL1 NR2E1 NR2E1 ATXN1L ATXN1L OSR2 OSR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (875 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (550 aa)
ENSPCOP00000020151EpCAM_N domain-containing protein. (283 aa)
ENSPCOP00000019705Uncharacterized protein. (583 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1306 aa)
HMX2H6 family homeobox 2. (273 aa)
LOC105808476Uncharacterized protein. (626 aa)
ENSPCOP00000026834Uncharacterized protein. (276 aa)
HOXA3Homeobox A3. (444 aa)
ELL3Elongation factor for RNA polymerase II 3. (396 aa)
ENSPCOP00000025432Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (747 aa)
ENSPCOP00000025005Uncharacterized protein. (351 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
CTNNB1Catenin beta 1. (781 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (367 aa)
SHOX2Short stature homeobox 2. (355 aa)
SIRT6Sirtuin 6. (305 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
SOX11Transcription factor SOX. (442 aa)
SOX9SRY-box transcription factor 9. (505 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
HMGA2Uncharacterized protein. (117 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
LOC105820095Uncharacterized protein. (784 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
ENSPCOP00000002776Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (330 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (221 aa)
ENSPCOP00000005396Uncharacterized protein. (130 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PRRX1Paired related homeobox 1. (245 aa)
PDCD2Programmed cell death 2. (343 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
EPCAMThyroglobulin type-1 domain-containing protein. (335 aa)
YAP1Uncharacterized protein. (504 aa)
FERMT2Fermitin family member 2. (693 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
HNRNPUUncharacterized protein. (824 aa)
ID4Inhibitor of DNA binding 4, HLH protein. (161 aa)
TIAL1TIA1 cytotoxic granule associated RNA binding protein like 1. (392 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (421 aa)
ATXN1LAtaxin 1 like. (689 aa)
OSR2Odd-skipped related transciption factor 2. (312 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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