STRINGSTRING
NSD1 NSD1 LOC105822932 LOC105822932 RNF220 RNF220 HAND1 HAND1 FOXC1 FOXC1 PAX6 PAX6 PARK7 PARK7 MSX1 MSX1 ZBTB7A ZBTB7A SOX11 SOX11 HEY2 HEY2 PER2 PER2 ENSPCOP00000031233 ENSPCOP00000031233 LIF LIF ENSPCOP00000000471 ENSPCOP00000000471 NIBAN2 NIBAN2 TRAF6 TRAF6 LHX2 LHX2 SRI SRI HAND2 HAND2 HEY1 HEY1 POU4F2 POU4F2 LOC105825287 LOC105825287 ANKRD33 ANKRD33 ANKRD33B ANKRD33B MAD2L2 MAD2L2 ENSPCOP00000008878 ENSPCOP00000008878 KLF4 KLF4 GATA3 GATA3 ZC4H2 ZC4H2 ZMPSTE24 ZMPSTE24 DDIT3 DDIT3 PARP1 PARP1 ZNF593 ZNF593 RB1 RB1 PSEN1 PSEN1 ENSPCOP00000014590 ENSPCOP00000014590 DDRGK1 DDRGK1 ENSPCOP00000015642 ENSPCOP00000015642 SIN3A SIN3A ZBTB7C ZBTB7C IGF1 IGF1 DOT1L DOT1L EP300 EP300 GATA1 GATA1 FBXW7 FBXW7 IFNG IFNG CTNNB1 CTNNB1 TGFB1 TGFB1 FBXW9 FBXW9 POU4F1 POU4F1 LAMTOR5 LAMTOR5 REST REST
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NSD1Nuclear receptor binding SET domain protein 1. (2606 aa)
LOC105822932Uncharacterized protein. (91 aa)
RNF220Ring finger protein 220. (566 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
FOXC1Forkhead box C1. (535 aa)
PAX6Paired box 6. (453 aa)
PARK7DJ-1_PfpI domain-containing protein. (155 aa)
MSX1Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (582 aa)
SOX11Transcription factor SOX. (442 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
PER2Period circadian regulator 2. (1265 aa)
ENSPCOP00000031233Uncharacterized protein. (318 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
ENSPCOP00000000471Uncharacterized protein. (96 aa)
NIBAN2Niban apoptosis regulator 2. (748 aa)
TRAF6TNF receptor-associated factor. (498 aa)
LHX2LIM homeobox 2. (406 aa)
SRISorcin. (198 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (308 aa)
POU4F2POU domain protein. (408 aa)
LOC105825287DJ-1_PfpI domain-containing protein. (189 aa)
ANKRD33Ankyrin repeat domain 33. (422 aa)
ANKRD33BAnkyrin repeat domain 33B. (491 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (235 aa)
ENSPCOP00000008878Uncharacterized protein. (329 aa)
KLF4Uncharacterized protein. (486 aa)
GATA3Uncharacterized protein. (444 aa)
ZC4H2Zinc finger C4H2-type containing. (224 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
ZNF593Zinc finger protein 593. (134 aa)
RB1RB transcriptional corepressor 1. (787 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
ENSPCOP00000014590Uncharacterized protein. (118 aa)
DDRGK1DDRGK domain containing 1. (315 aa)
ENSPCOP00000015642DJ-1_PfpI domain-containing protein. (175 aa)
SIN3ASIN3 transcription regulator family member A. (1274 aa)
ZBTB7CZinc finger and BTB domain containing 7C. (620 aa)
IGF1Insulin like growth factor 1. (208 aa)
DOT1LHistone-lysine N-methyltransferase, H3 lysine-79 specific. (1511 aa)
EP300E1A binding protein p300. (2424 aa)
GATA1GATA binding protein 1. (413 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
CTNNB1Catenin beta 1. (781 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
FBXW9F-box and WD repeat domain containing 9. (478 aa)
POU4F1POU domain protein. (421 aa)
LAMTOR5Uncharacterized protein. (149 aa)
RESTUncharacterized protein. (1018 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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