32 items (Propithecus coquereli) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	SLC30A10	Solute carrier family 30 member 10. (486 aa)
	FBXO5	F-box protein 5. (333 aa)
	BCL6	BCL6 transcription repressor. (706 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	PLK2	Serine/threonine-protein kinase PLK. (685 aa)
	ENSPCOP00000006358	Uncharacterized protein. (124 aa)
	TBX2	T-box transcription factor 2. (713 aa)
	ENSPCOP00000002980	CSD_1 domain-containing protein. (281 aa)
	ENSPCOP00000002776	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (330 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	HMGA2	Uncharacterized protein. (117 aa)
	LOC105819920	Uncharacterized protein. (116 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	SIRT1	Sirtuin 1. (743 aa)
	BCL2L12	BCL2 like 12. (329 aa)
	CDK6	Cyclin dependent kinase 6. (263 aa)
	ENSPCOP00000026280	CSD_1 domain-containing protein. (299 aa)
	ENSPCOP00000026277	CSP domain-containing protein. (299 aa)
	ENSPCOP00000025962	CSP domain-containing protein. (305 aa)
	ENSPCOP00000025432	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (747 aa)
	MIF	Uncharacterized protein. (115 aa)
	ENSPCOP00000022535	CSD_1 domain-containing protein. (307 aa)
	ENSPCOP00000021190	CSD_1 domain-containing protein. (328 aa)
	ENSPCOP00000021169	CSP domain-containing protein. (280 aa)
	TERF2	Telomeric repeat binding factor 2. (542 aa)
	ENSPCOP00000018545	CSD_1 domain-containing protein. (310 aa)
	FZR1	Fizzy and cell division cycle 20 related 1. (493 aa)
	MAP3K3	Mitogen-activated protein kinase kinase kinase 3. (653 aa)
	RBL1	RB transcriptional corepressor like 1. (935 aa)
	ENSPCOP00000014861	CSD domain-containing protein. (272 aa)
	SIRT6	Sirtuin 6. (305 aa)

Your Current Organism:

Propithecus coquereli

NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT3	CDK6	ENSPCOP00000028519	ENSPCOP00000026377	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cyclin dependent kinase 6.	0.438
AKT3	MAP3K3	ENSPCOP00000028519	ENSPCOP00000016625	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase kinase 3.	0.447
AKT3	PTEN	ENSPCOP00000028519	ENSPCOP00000001519	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.821
AKT3	SIRT1	ENSPCOP00000028519	ENSPCOP00000027970	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Sirtuin 1.	0.493
AKT3	SIRT6	ENSPCOP00000028519	ENSPCOP00000031867	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Sirtuin 6.	0.453
AKT3	TP63	ENSPCOP00000028519	ENSPCOP00000030966	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.611
BCL6	SIRT1	ENSPCOP00000009538	ENSPCOP00000027970	BCL6 transcription repressor.	Sirtuin 1.	0.535
CDK6	AKT3	ENSPCOP00000026377	ENSPCOP00000028519	Cyclin dependent kinase 6.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.438
CDK6	ENSPCOP00000002776	ENSPCOP00000026377	ENSPCOP00000002776	Cyclin dependent kinase 6.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...]	0.538
CDK6	ENSPCOP00000002980	ENSPCOP00000026377	ENSPCOP00000002980	Cyclin dependent kinase 6.	CSD_1 domain-containing protein.	0.412
CDK6	ENSPCOP00000006358	ENSPCOP00000026377	ENSPCOP00000006358	Cyclin dependent kinase 6.	Uncharacterized protein.	0.412
CDK6	ENSPCOP00000014861	ENSPCOP00000026377	ENSPCOP00000014861	Cyclin dependent kinase 6.	CSD domain-containing protein.	0.412
CDK6	ENSPCOP00000018545	ENSPCOP00000026377	ENSPCOP00000018545	Cyclin dependent kinase 6.	CSD_1 domain-containing protein.	0.412
CDK6	ENSPCOP00000021169	ENSPCOP00000026377	ENSPCOP00000021169	Cyclin dependent kinase 6.	CSP domain-containing protein.	0.412
CDK6	ENSPCOP00000021190	ENSPCOP00000026377	ENSPCOP00000021190	Cyclin dependent kinase 6.	CSD_1 domain-containing protein.	0.412
CDK6	ENSPCOP00000022535	ENSPCOP00000026377	ENSPCOP00000022535	Cyclin dependent kinase 6.	CSD_1 domain-containing protein.	0.412
CDK6	ENSPCOP00000025432	ENSPCOP00000026377	ENSPCOP00000025432	Cyclin dependent kinase 6.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...]	0.538
CDK6	ENSPCOP00000025962	ENSPCOP00000026377	ENSPCOP00000025962	Cyclin dependent kinase 6.	CSP domain-containing protein.	0.412
CDK6	ENSPCOP00000026277	ENSPCOP00000026377	ENSPCOP00000026277	Cyclin dependent kinase 6.	CSP domain-containing protein.	0.412
CDK6	ENSPCOP00000026280	ENSPCOP00000026377	ENSPCOP00000026280	Cyclin dependent kinase 6.	CSD_1 domain-containing protein.	0.412