STRINGSTRING
ENSPCOP00000002776 ENSPCOP00000002776 GDNF GDNF EYA2 EYA2 RIPK1 RIPK1 SGK3 SGK3 ENSPCOP00000025432 ENSPCOP00000025432 MCL1 MCL1 GAS1 GAS1 AKT1 AKT1 CTNNA1 CTNNA1 NRG1 NRG1 SNAI2 SNAI2 UNC5B UNC5B EYA3 EYA3 AGAP2 AGAP2 FGF10 FGF10 CSF2 CSF2 ENSPCOP00000009641 ENSPCOP00000009641 TNF TNF EYA4 EYA4 IL7 IL7 EYA1 EYA1 STRADB STRADB ZC3HC1 ZC3HC1 IL1B IL1B CX3CL1 CX3CL1 GATA1 GATA1 COL2A1 COL2A1 MAP2K5 MAP2K5 GFRAL GFRAL MAPK7 MAPK7 IFI6 IFI6 BCL2L1 BCL2L1 BCL2 BCL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPCOP00000002776Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (330 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (539 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (643 aa)
SGK3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
ENSPCOP00000025432Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (747 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (350 aa)
GAS1Growth arrest specific 1. (340 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CTNNA1Catenin alpha 1. (906 aa)
NRG1Neuregulin 1. (710 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
UNC5BUnc-5 netrin receptor B. (932 aa)
EYA3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1193 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
CSF2Colony stimulating factor 2. (146 aa)
ENSPCOP00000009641Uncharacterized protein. (136 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (235 aa)
EYA4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (522 aa)
IL7Interleukin 7. (133 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
STRADBSTE20 related adaptor beta. (377 aa)
ZC3HC1Zinc finger C3HC-type containing 1. (502 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (405 aa)
GATA1GATA binding protein 1. (413 aa)
COL2A1Collagen type II alpha 1 chain. (1487 aa)
MAP2K5Mitogen-activated protein kinase kinase 5. (389 aa)
GFRALGDNF family receptor alpha like. (338 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (802 aa)
IFI6Interferon alpha inducible protein 6. (131 aa)
BCL2L1BCL2 like 1. (233 aa)
BCL2BCL2 apoptosis regulator. (234 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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