STRINGSTRING
MARCHF7 MARCHF7 PLAGL2 PLAGL2 MCL1 MCL1 BAG5 BAG5 CREB3L1 CREB3L1 ELL3 ELL3 CD44 CD44 TAF6 TAF6 ENSPCOP00000027398 ENSPCOP00000027398 SGMS1 SGMS1 ENSPCOP00000027462 ENSPCOP00000027462 SERINC3 SERINC3 BCL2L12 BCL2L12 SIRT1 SIRT1 LOC105826437 LOC105826437 CLUL1 CLUL1 PTPMT1 PTPMT1 SFPQ SFPQ ENSPCOP00000028930 ENSPCOP00000028930 AKT1 AKT1 VNN1 VNN1 PARK7 PARK7 MSX1 MSX1 NOX1 NOX1 FIS1 FIS1 ERP29 ERP29 DDIAS DDIAS BAD BAD HSPB1 HSPB1 RIPK3 RIPK3 IL20RA IL20RA PYCARD PYCARD LOC105819920 LOC105819920 TP53 TP53 RPS3 RPS3 BID BID FBXW9 FBXW9 PINK1 PINK1 LRRK2 LRRK2 ENSPCOP00000024882 ENSPCOP00000024882 CAV1 CAV1 HDAC1 HDAC1 NKX3-1 NKX3-1 EIF2AK3 EIF2AK3 CREB3 CREB3 USP47 USP47 IL19 IL19 TRIM32 TRIM32 PDX1 PDX1 NOL3 NOL3 NFE2L2 NFE2L2 EPO EPO NONO NONO PMAIP1 PMAIP1 NCK2 NCK2 CLU CLU PARL PARL NACC2 NACC2 MYC MYC FBH1 FBH1 YBX3 YBX3 SKIL SKIL XBP1 XBP1 VDAC2 VDAC2 TMEM161A TMEM161A LOC105825287 LOC105825287 BOK BOK NDUFS3 NDUFS3 HYOU1 HYOU1 HIF1A HIF1A ENSPCOP00000004787 ENSPCOP00000004787 ENSPCOP00000004814 ENSPCOP00000004814 CXCL12 CXCL12 WFS1 WFS1 SOD2 SOD2 ZNF385A ZNF385A BCLAF1 BCLAF1 BDKRB2 BDKRB2 DAPK2 DAPK2 BCL2L10 BCL2L10 NDUFA13 NDUFA13 SNAI2 SNAI2 PTGS2 PTGS2 PTPN1 PTPN1 TPT1 TPT1 CD74 CD74 ENSPCOP00000009641 ENSPCOP00000009641 LCK LCK ARHGEF2 ARHGEF2 DDIT3 DDIT3 SIAH1 SIAH1 SYVN1 SYVN1 PARP1 PARP1 RTKN2 RTKN2 MUC1 MUC1 ATAD5 ATAD5 LOC105810428 LOC105810428 PTPN2 PTPN2 MMP9 MMP9 TREM2 TREM2 ARMC10 ARMC10 STYXL1 STYXL1 TRIAP1 TRIAP1 LOC105814704 LOC105814704 CDKN2D CDKN2D GSDME GSDME RPS7 RPS7 P4HB P4HB PRKRA PRKRA PPIF PPIF GRINA GRINA S100A9 S100A9 URI1 URI1 OPA1 OPA1 ENSPCOP00000015642 ENSPCOP00000015642 MAPK7 MAPK7 NOC2L NOC2L LOC105816059 LOC105816059 BBC3 BBC3 PRKN PRKN PIK3CB PIK3CB ING2 ING2 SNAI1 SNAI1 PTTG1IP PTTG1IP SELENOS SELENOS SRC SRC TRAP1 TRAP1 RAD9A RAD9A SFRP2 SFRP2 BAX BAX FBXW7 FBXW7 ENSPCOP00000020030 ENSPCOP00000020030 LOC105818728 LOC105818728 TXNDC12 TXNDC12 KDM1A KDM1A BCL2L1 BCL2L1 BCL2 BCL2 DNM1L DNM1L ENSPCOP00000021345 ENSPCOP00000021345 CCAR2 CCAR2 ENSPCOP00000022343 ENSPCOP00000022343 HTRA2 HTRA2 FLCN FLCN MIF MIF HELLS HELLS VNN3 VNN3 NME5 NME5 RACK1 RACK1 BCL2L11 BCL2L11 RRM2B RRM2B ACKR3 ACKR3 NCK1 NCK1 MAPK8IP1 MAPK8IP1 PIAS4 PIAS4 ENSPCOP00000001724 ENSPCOP00000001724 FAM167A FAM167A S100A8 S100A8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MARCHF7Membrane associated ring-CH-type finger 7. (705 aa)
PLAGL2PLAG1 like zinc finger 2. (496 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (350 aa)
BAG5BCL2 associated athanogene 5. (470 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
ELL3Elongation factor for RNA polymerase II 3. (396 aa)
CD44CD44 molecule (Indian blood group). (746 aa)
TAF6TATA-box binding protein associated factor 6. (732 aa)
ENSPCOP00000027398KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (281 aa)
SGMS1Sphingomyelin synthase 1. (419 aa)
ENSPCOP00000027462TCTP domain-containing protein; Belongs to the TCTP family. (160 aa)
SERINC3Serine incorporator 3. (473 aa)
BCL2L12BCL2 like 12. (329 aa)
SIRT1Sirtuin 1. (743 aa)
LOC105826437E3 ubiquitin-protein ligase TRIM32. (653 aa)
CLUL1Clusterin; Belongs to the clusterin family. (473 aa)
PTPMT1Protein tyrosine phosphatase mitochondrial 1. (193 aa)
SFPQSplicing factor proline and glutamine rich. (706 aa)
ENSPCOP00000028930Uncharacterized protein. (241 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
VNN1Vanin 1. (514 aa)
PARK7DJ-1_PfpI domain-containing protein. (155 aa)
MSX1Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
NOX1NADPH oxidase 1. (564 aa)
FIS1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
ERP29Endoplasmic reticulum resident protein 29; Does not seem to be a disulfide isomerase. (260 aa)
DDIASRep_fac-A_C domain-containing protein. (169 aa)
BADBCL2 associated agonist of cell death. (168 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (206 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (516 aa)
IL20RAInterleukin 20 receptor subunit alpha. (556 aa)
PYCARDPYD and CARD domain containing. (195 aa)
LOC105819920Uncharacterized protein. (116 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (220 aa)
FBXW9F-box and WD repeat domain containing 9. (478 aa)
PINK1PTEN induced kinase 1. (581 aa)
LRRK2Leucine rich repeat kinase 2. (2427 aa)
ENSPCOP00000024882Ribosomal_S3_C domain-containing protein. (231 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
NKX3-1NK3 homeobox 1. (226 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1115 aa)
CREB3cAMP responsive element binding protein 3. (373 aa)
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1376 aa)
IL19Interleukin 19. (146 aa)
TRIM32Uncharacterized protein. (653 aa)
PDX1Pancreatic and duodenal homeobox 1. (282 aa)
NOL3Nucleolar protein 3. (204 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (606 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (194 aa)
NONONon-POU domain containing octamer binding. (470 aa)
PMAIP1Uncharacterized protein. (54 aa)
NCK2Cytoplasmic protein. (380 aa)
CLUClusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (450 aa)
PARLRhomboid domain-containing protein. (362 aa)
NACC2NACC family member 2. (583 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (453 aa)
FBH1F-box DNA helicase 1. (1056 aa)
YBX3Y-box binding protein 3. (242 aa)
SKILSKI like proto-oncogene. (664 aa)
XBP1BZIP domain-containing protein. (377 aa)
VDAC2Voltage dependent anion channel 2. (309 aa)
TMEM161ATransmembrane protein 161A. (479 aa)
LOC105825287DJ-1_PfpI domain-containing protein. (189 aa)
BOKBCL2 family apoptosis regulator BOK. (213 aa)
NDUFS3NADH:ubiquinone oxidoreductase core subunit S3; Belongs to the complex I 30 kDa subunit family. (268 aa)
HYOU1Hypoxia up-regulated 1. (997 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
ENSPCOP00000004787Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (445 aa)
ENSPCOP00000004814TCTP domain-containing protein; Belongs to the TCTP family. (172 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (159 aa)
WFS1Wolframin ER transmembrane glycoprotein. (887 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
ZNF385AZinc finger protein 385A. (414 aa)
BCLAF1BCL2 associated transcription factor 1. (921 aa)
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (393 aa)
DAPK2Death associated protein kinase 2; Belongs to the protein kinase superfamily. (488 aa)
BCL2L10Uncharacterized protein. (192 aa)
NDUFA13NADH:ubiquinone oxidoreductase subunit A13. (144 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
TPT1TCTP domain-containing protein; Belongs to the TCTP family. (197 aa)
CD74CD74 molecule. (298 aa)
ENSPCOP00000009641Uncharacterized protein. (136 aa)
LCKTyrosine-protein kinase. (417 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1013 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
SIAH1E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (312 aa)
SYVN1Synoviolin 1. (622 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
RTKN2Rhotekin 2. (609 aa)
MUC1SEA domain-containing protein. (168 aa)
ATAD5ATPase family AAA domain containing 5. (1646 aa)
LOC105810428Uncharacterized protein. (274 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (415 aa)
MMP9Matrix metallopeptidase 9. (709 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (224 aa)
ARMC10Armadillo repeat containing 10. (310 aa)
STYXL1Serine/threonine/tyrosine interacting like 1. (312 aa)
TRIAP1Uncharacterized protein. (76 aa)
LOC105814704TCTP domain-containing protein; Belongs to the TCTP family. (214 aa)
CDKN2DCyclin dependent kinase inhibitor 2D. (166 aa)
GSDMEGasdermin E. (492 aa)
RPS740S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (194 aa)
P4HBProtein disulfide-isomerase. (510 aa)
PRKRAProtein activator of interferon induced protein kinase EIF2AK2. (313 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (207 aa)
GRINAGlutamate ionotropic receptor NMDA type subunit associated protein 1. (371 aa)
S100A9S100 calcium binding protein A9; Belongs to the S-100 family. (154 aa)
URI1URI1 prefoldin like chaperone. (508 aa)
OPA1OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (997 aa)
ENSPCOP00000015642DJ-1_PfpI domain-containing protein. (175 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (802 aa)
NOC2LNOC2 like nucleolar associated transcriptional repressor. (744 aa)
LOC105816059Uncharacterized protein. (256 aa)
BBC3BCL2 binding component 3. (260 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (460 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
ING2Inhibitor of growth protein. (281 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
PTTG1IPPTTG1 interacting protein. (180 aa)
SELENOSSelenoprotein S. (187 aa)
SRCTyrosine-protein kinase. (543 aa)
TRAP1TNF receptor associated protein 1. (681 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (393 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
BAXBCL2 associated X, apoptosis regulator. (199 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
ENSPCOP00000020030KH type-2 domain-containing protein. (93 aa)
LOC105818728TCTP domain-containing protein; Belongs to the TCTP family. (165 aa)
TXNDC12Thioredoxin domain containing 12. (172 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (875 aa)
BCL2L1BCL2 like 1. (233 aa)
BCL2BCL2 apoptosis regulator. (234 aa)
DNM1LDynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (749 aa)
ENSPCOP00000021345BTB domain-containing protein. (236 aa)
CCAR2Cell cycle and apoptosis regulator 2. (922 aa)
ENSPCOP00000022343TCTP domain-containing protein; Belongs to the TCTP family. (161 aa)
HTRA2HtrA serine peptidase 2. (458 aa)
FLCNFolliculin. (579 aa)
MIFUncharacterized protein. (115 aa)
HELLSHelicase, lymphoid specific. (833 aa)
VNN3Vanin 3. (274 aa)
NME5NME/NM23 family member 5; Belongs to the NDK family. (212 aa)
RACK1Receptor for activated C kinase 1. (317 aa)
BCL2L11BCL2 like 11. (200 aa)
RRM2BRibonucleotide reductase regulatory TP53 inducible subunit M2B. (351 aa)
ACKR3Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (362 aa)
NCK1Cytoplasmic protein. (377 aa)
MAPK8IP1Mitogen-activated protein kinase 8 interacting protein 1. (711 aa)
PIAS4Protein inhibitor of activated STAT 4. (465 aa)
ENSPCOP0000000172440S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (207 aa)
FAM167AFamily with sequence similarity 167 member A. (217 aa)
S100A8S100 calcium binding protein A8; Belongs to the S-100 family. (89 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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