STRINGSTRING
USP47 USP47 RRM2B RRM2B ACKR3 ACKR3 MAPK8IP1 MAPK8IP1 TRIM32 TRIM32 PDX1 PDX1 NOL3 NOL3 NFE2L2 NFE2L2 EPO EPO FAM167A FAM167A NONO NONO CLU CLU PARL PARL YBX3 YBX3 XBP1 XBP1 VDAC2 VDAC2 TMEM161A TMEM161A LOC105825287 LOC105825287 NDUFS3 NDUFS3 HYOU1 HYOU1 HIF1A HIF1A ENSPCOP00000004787 ENSPCOP00000004787 ENSPCOP00000004814 ENSPCOP00000004814 CXCL12 CXCL12 WFS1 WFS1 SOD2 SOD2 ZNF385A ZNF385A BDKRB2 BDKRB2 BCL2L10 BCL2L10 NDUFA13 NDUFA13 SNAI2 SNAI2 PTGS2 PTGS2 PTPN1 PTPN1 TPT1 TPT1 CD74 CD74 ENSPCOP00000009641 ENSPCOP00000009641 ARHGEF2 ARHGEF2 SYVN1 SYVN1 RTKN2 RTKN2 MUC1 MUC1 ATAD5 ATAD5 LOC105810428 LOC105810428 MMP9 MMP9 ARMC10 ARMC10 TRIAP1 TRIAP1 LOC105814704 LOC105814704 CDKN2D CDKN2D PPIF PPIF GRINA GRINA URI1 URI1 OPA1 OPA1 ENSPCOP00000015642 ENSPCOP00000015642 MAPK7 MAPK7 NOC2L NOC2L LOC105816059 LOC105816059 PRKN PRKN PIK3CB PIK3CB ING2 ING2 SNAI1 SNAI1 PTTG1IP PTTG1IP SELENOS SELENOS SRC SRC TRAP1 TRAP1 SFRP2 SFRP2 LOC105818728 LOC105818728 TXNDC12 TXNDC12 KDM1A KDM1A BCL2L1 BCL2L1 BCL2 BCL2 ENSPCOP00000021345 ENSPCOP00000021345 CCAR2 CCAR2 ENSPCOP00000022343 ENSPCOP00000022343 HTRA2 HTRA2 MIF MIF HELLS HELLS NME5 NME5 PINK1 PINK1 LRRK2 LRRK2 HDAC1 HDAC1 MARCHF7 MARCHF7 CREB3 CREB3 MCL1 MCL1 BAG5 BAG5 CREB3L1 CREB3L1 ELL3 ELL3 CD44 CD44 ENSPCOP00000027462 ENSPCOP00000027462 BCL2L12 BCL2L12 SIRT1 SIRT1 LOC105826437 LOC105826437 CLUL1 CLUL1 AKT1 AKT1 PARK7 PARK7 DDIAS DDIAS HSPB1 HSPB1 LOC105819920 LOC105819920 BID BID
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1376 aa)
RRM2BRibonucleotide reductase regulatory TP53 inducible subunit M2B. (351 aa)
ACKR3Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (362 aa)
MAPK8IP1Mitogen-activated protein kinase 8 interacting protein 1. (711 aa)
TRIM32Uncharacterized protein. (653 aa)
PDX1Pancreatic and duodenal homeobox 1. (282 aa)
NOL3Nucleolar protein 3. (204 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (606 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (194 aa)
FAM167AFamily with sequence similarity 167 member A. (217 aa)
NONONon-POU domain containing octamer binding. (470 aa)
CLUClusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (450 aa)
PARLRhomboid domain-containing protein. (362 aa)
YBX3Y-box binding protein 3. (242 aa)
XBP1BZIP domain-containing protein. (377 aa)
VDAC2Voltage dependent anion channel 2. (309 aa)
TMEM161ATransmembrane protein 161A. (479 aa)
LOC105825287DJ-1_PfpI domain-containing protein. (189 aa)
NDUFS3NADH:ubiquinone oxidoreductase core subunit S3; Belongs to the complex I 30 kDa subunit family. (268 aa)
HYOU1Hypoxia up-regulated 1. (997 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
ENSPCOP00000004787Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (445 aa)
ENSPCOP00000004814TCTP domain-containing protein; Belongs to the TCTP family. (172 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (159 aa)
WFS1Wolframin ER transmembrane glycoprotein. (887 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
ZNF385AZinc finger protein 385A. (414 aa)
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (393 aa)
BCL2L10Uncharacterized protein. (192 aa)
NDUFA13NADH:ubiquinone oxidoreductase subunit A13. (144 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
TPT1TCTP domain-containing protein; Belongs to the TCTP family. (197 aa)
CD74CD74 molecule. (298 aa)
ENSPCOP00000009641Uncharacterized protein. (136 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1013 aa)
SYVN1Synoviolin 1. (622 aa)
RTKN2Rhotekin 2. (609 aa)
MUC1SEA domain-containing protein. (168 aa)
ATAD5ATPase family AAA domain containing 5. (1646 aa)
LOC105810428Uncharacterized protein. (274 aa)
MMP9Matrix metallopeptidase 9. (709 aa)
ARMC10Armadillo repeat containing 10. (310 aa)
TRIAP1Uncharacterized protein. (76 aa)
LOC105814704TCTP domain-containing protein; Belongs to the TCTP family. (214 aa)
CDKN2DCyclin dependent kinase inhibitor 2D. (166 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (207 aa)
GRINAGlutamate ionotropic receptor NMDA type subunit associated protein 1. (371 aa)
URI1URI1 prefoldin like chaperone. (508 aa)
OPA1OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (997 aa)
ENSPCOP00000015642DJ-1_PfpI domain-containing protein. (175 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (802 aa)
NOC2LNOC2 like nucleolar associated transcriptional repressor. (744 aa)
LOC105816059Uncharacterized protein. (256 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (460 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
ING2Inhibitor of growth protein. (281 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
PTTG1IPPTTG1 interacting protein. (180 aa)
SELENOSSelenoprotein S. (187 aa)
SRCTyrosine-protein kinase. (543 aa)
TRAP1TNF receptor associated protein 1. (681 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
LOC105818728TCTP domain-containing protein; Belongs to the TCTP family. (165 aa)
TXNDC12Thioredoxin domain containing 12. (172 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (875 aa)
BCL2L1BCL2 like 1. (233 aa)
BCL2BCL2 apoptosis regulator. (234 aa)
ENSPCOP00000021345BTB domain-containing protein. (236 aa)
CCAR2Cell cycle and apoptosis regulator 2. (922 aa)
ENSPCOP00000022343TCTP domain-containing protein; Belongs to the TCTP family. (161 aa)
HTRA2HtrA serine peptidase 2. (458 aa)
MIFUncharacterized protein. (115 aa)
HELLSHelicase, lymphoid specific. (833 aa)
NME5NME/NM23 family member 5; Belongs to the NDK family. (212 aa)
PINK1PTEN induced kinase 1. (581 aa)
LRRK2Leucine rich repeat kinase 2. (2427 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
MARCHF7Membrane associated ring-CH-type finger 7. (705 aa)
CREB3cAMP responsive element binding protein 3. (373 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (350 aa)
BAG5BCL2 associated athanogene 5. (470 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
ELL3Elongation factor for RNA polymerase II 3. (396 aa)
CD44CD44 molecule (Indian blood group). (746 aa)
ENSPCOP00000027462TCTP domain-containing protein; Belongs to the TCTP family. (160 aa)
BCL2L12BCL2 like 12. (329 aa)
SIRT1Sirtuin 1. (743 aa)
LOC105826437E3 ubiquitin-protein ligase TRIM32. (653 aa)
CLUL1Clusterin; Belongs to the clusterin family. (473 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PARK7DJ-1_PfpI domain-containing protein. (155 aa)
DDIASRep_fac-A_C domain-containing protein. (169 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (206 aa)
LOC105819920Uncharacterized protein. (116 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (220 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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