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HMGCR HMGCR USP30 USP30 ECI2 ECI2 LOC105812763 LOC105812763 KIAA1841 KIAA1841 ACOX3 ACOX3 BAAT BAAT XDH XDH HSDL2 HSDL2 PEX16 PEX16 TMEM35B TMEM35B TMEM135 TMEM135 RIDA RIDA VWA8 VWA8 ISOC2 ISOC2 PEX11A PEX11A CRAT CRAT AMACR AMACR DAO DAO PECR PECR ENSPCOP00000006443 ENSPCOP00000006443 PXMP2 PXMP2 MLYCD MLYCD LOC105823900 LOC105823900 ACOT8 ACOT8 ABCD4 ABCD4 GRHPR GRHPR PEX1 PEX1 FABP1 FABP1 MARF1 MARF1 PAOX PAOX AGXT AGXT DHRS7B DHRS7B LACC1 LACC1 TYSND1 TYSND1 ISOC1 ISOC1 ENSPCOP00000002732 ENSPCOP00000002732 ENSPCOP00000002844 ENSPCOP00000002844 CPT1A CPT1A PEX5L PEX5L SLC27A2 SLC27A2 DDO DDO NUDT12 NUDT12 TKT TKT MAP2K2 MAP2K2 ENSPCOP00000001435 ENSPCOP00000001435 CD33 CD33 SCP2 SCP2 PLAAT3 PLAAT3 ECH1 ECH1 MVK MVK ALDH3A2 ALDH3A2 PEX5 PEX5 ZADH2 ZADH2 OSGIN1 OSGIN1 PEX6 PEX6 EHHADH EHHADH LOC105823281 LOC105823281 ABCD1 ABCD1 CRYM CRYM HMGCL HMGCL ABCD3 ABCD3 TMCO4 TMCO4 POMC POMC HSD17B4 HSD17B4 LOC105819935 LOC105819935 ATAD1 ATAD1 PMVK PMVK CLYBL CLYBL PEX10 PEX10 EPHX2 EPHX2 ENSPCOP00000030386 ENSPCOP00000030386 FAR2 FAR2 LONP2 LONP2 FIS1 FIS1 ENSPCOP00000030006 ENSPCOP00000030006 SYT7 SYT7 FAR1 FAR1 ACOX2 ACOX2 CROT CROT IMPDH2 IMPDH2 ACOT4 ACOT4 FAM185A FAM185A PXT1 PXT1 RUSC1 RUSC1 PXMP4 PXMP4 HAO1 HAO1 PEX26 PEX26 NOS2 NOS2 SLC25A17 SLC25A17 TMEM35A TMEM35A PIPOX PIPOX ENSPCOP00000023521 ENSPCOP00000023521 TTC1 TTC1 ENSPCOP00000022250 ENSPCOP00000022250 CLDN15 CLDN15 PHYH PHYH PLAAT2 PLAAT2 ACOXL ACOXL ACOX1 ACOX1 PEX14 PEX14 PRDX5 PRDX5 ACSL3 ACSL3 NUDT7 NUDT7 HAO2 HAO2 DECR2 DECR2 MAVS MAVS GNPAT GNPAT ABCD2 ABCD2 IDH1 IDH1 ACAD11 ACAD11 ACAA1 ACAA1 PEX3 PEX3 ATM ATM ENSPCOP00000017312 ENSPCOP00000017312 LOC105821449 LOC105821449 MPV17L MPV17L SERHL2 SERHL2 LOC105820649 LOC105820649 PEX11G PEX11G ACBD4 ACBD4 MGST1 MGST1 GSTK1 GSTK1 HACL1 HACL1 IDI1 IDI1 MPV17 MPV17 ACSL1 ACSL1 PEX12 PEX12 PEX11B PEX11B AGPS AGPS PNPLA8 PNPLA8 MUL1 MUL1 IDE IDE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
USP30Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (517 aa)
ECI2Enoyl-CoA delta isomerase 2. (323 aa)
LOC105812763Uncharacterized protein. (279 aa)
KIAA1841KIAA1841. (572 aa)
ACOX3Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (700 aa)
BAATBile acid-CoA:amino acid N-acyltransferase. (420 aa)
XDHXanthine dehydrogenase. (1313 aa)
HSDL2Hydroxysteroid dehydrogenase like 2. (361 aa)
PEX16Peroxisomal membrane protein PEX16. (337 aa)
TMEM35BTransmembrane protein 35B. (153 aa)
TMEM135Transmembrane protein 135. (457 aa)
RIDAUncharacterized protein. (137 aa)
VWA8Von Willebrand factor A domain containing 8. (1693 aa)
ISOC2Isochorismatase domain containing 2. (205 aa)
PEX11APeroxisomal biogenesis factor 11 alpha. (247 aa)
CRATCarnitine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (626 aa)
AMACRAlpha-methylacyl-CoA racemase. (394 aa)
DAODAO domain-containing protein. (154 aa)
PECRPeroxisomal trans-2-enoyl-CoA reductase. (303 aa)
ENSPCOP00000006443Isochorismatase domain-containing protein. (260 aa)
PXMP2Peroxisomal membrane protein 2; Belongs to the peroxisomal membrane protein PXMP2/4 family. (195 aa)
MLYCDMalonyl-CoA decarboxylase. (498 aa)
LOC105823900Uricase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. Belongs to the uricase family. (303 aa)
ACOT8Acyl-CoA thioesterase 8. (317 aa)
ABCD4ATP binding cassette subfamily D member 4. (606 aa)
GRHPRGlyoxylate and hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (347 aa)
PEX1Peroxisomal biogenesis factor 1. (1191 aa)
FABP1FABP domain-containing protein. (69 aa)
MARF1Meiosis regulator and mRNA stability factor 1. (1739 aa)
PAOXAmino_oxidase domain-containing protein. (511 aa)
AGXTSerine--pyruvate aminotransferase. (392 aa)
DHRS7BDehydrogenase/reductase 7B; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (325 aa)
LACC1Uncharacterized protein. (380 aa)
TYSND1Trypsin domain containing 1. (566 aa)
ISOC1Isochorismatase domain-containing protein. (298 aa)
ENSPCOP00000002732C2 domain-containing protein. (385 aa)
ENSPCOP00000002844Uncharacterized protein. (60 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (697 aa)
PEX5LPeroxisomal biogenesis factor 5 like. (650 aa)
SLC27A2Solute carrier family 27 member 2. (620 aa)
DDOD-aspartate oxidase. (369 aa)
NUDT12Nudix hydrolase 12. (461 aa)
TKTTransketolase. (623 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
ENSPCOP00000001435Uncharacterized protein. (332 aa)
CD33Ig-like domain-containing protein. (339 aa)
SCP2Sterol carrier protein 2; Belongs to the thiolase-like superfamily. Thiolase family. (495 aa)
PLAAT3Phospholipase A and acyltransferase 3. (162 aa)
ECH1Enoyl-CoA hydratase 1; Belongs to the enoyl-CoA hydratase/isomerase family. (328 aa)
MVKMevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (396 aa)
ALDH3A2Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (507 aa)
PEX5Peroxisomal biogenesis factor 5. (659 aa)
ZADH2Zinc binding alcohol dehydrogenase domain containing 2. (377 aa)
OSGIN1Oxidative stress induced growth inhibitor 1. (529 aa)
PEX6Peroxisomal biogenesis factor 6. (980 aa)
EHHADHEnoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (723 aa)
LOC105823281GHMP_kinases_C domain-containing protein. (116 aa)
ABCD1ATP binding cassette subfamily D member 1. (746 aa)
CRYMCrystallin mu. (314 aa)
HMGCL3-hydroxy-3-methylglutaryl-CoA lyase. (325 aa)
ABCD3ATP binding cassette subfamily D member 3. (659 aa)
TMCO4Transmembrane and coiled-coil domains 4. (629 aa)
POMCProopiomelanocortin. (258 aa)
HSD17B4Hydroxysteroid 17-beta dehydrogenase 4. (705 aa)
LOC105819935Uncharacterized protein. (397 aa)
ATAD1ATPase family AAA domain containing 1; Belongs to the AAA ATPase family. (383 aa)
PMVKPhosphomevalonate kinase. (192 aa)
CLYBLCitrate lyase beta like. (340 aa)
PEX10Peroxisomal biogenesis factor 10. (326 aa)
EPHX2Epoxide hydrolase 2. (530 aa)
ENSPCOP00000030386Uncharacterized protein. (122 aa)
FAR2Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (515 aa)
LONP2Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta- oxidation through degradation of the self-processed forms of TYSND1. (821 aa)
FIS1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
ENSPCOP00000030006Uncharacterized protein. (246 aa)
SYT7Synaptotagmin 7. (686 aa)
FAR1Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (515 aa)
ACOX2Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (679 aa)
CROTCarnitine O-octanoyltransferase; Belongs to the carnitine/choline acetyltransferase family. (612 aa)
IMPDH2Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (514 aa)
ACOT4Acyl-CoA thioesterase 4. (421 aa)
FAM185AFamily with sequence similarity 185 member A. (390 aa)
PXT1Uncharacterized protein. (84 aa)
RUSC1RUN and SH3 domain containing 1. (903 aa)
PXMP4Peroxisomal membrane protein 4; Belongs to the peroxisomal membrane protein PXMP2/4 family. (212 aa)
HAO1Hydroxyacid oxidase 1. (310 aa)
PEX26Peroxisomal biogenesis factor 26. (300 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1104 aa)
SLC25A17Solute carrier family 25 member 17; Belongs to the mitochondrial carrier (TC 2.A.29) family. (300 aa)
TMEM35ATransmembrane protein 35A. (167 aa)
PIPOXPipecolic acid and sarcosine oxidase. (390 aa)
ENSPCOP00000023521Nudix hydrolase domain-containing protein. (155 aa)
TTC1Tetratricopeptide repeat domain 1. (242 aa)
ENSPCOP00000022250Uncharacterized protein. (299 aa)
CLDN15Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (228 aa)
PHYHPhytanoyl-CoA 2-hydroxylase. (239 aa)
PLAAT2Phospholipase A and acyltransferase 2. (163 aa)
ACOXLAcyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (580 aa)
ACOX1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (566 aa)
PEX14Peroxisomal biogenesis factor 14. (376 aa)
PRDX5Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (225 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (673 aa)
NUDT7Nudix hydrolase 7. (238 aa)
HAO2Hydroxyacid oxidase 2. (353 aa)
DECR22,4-dienoyl-CoA reductase 2. (292 aa)
MAVSMitochondrial antiviral signaling protein. (514 aa)
GNPATDihydroxyacetone phosphate acyltransferase. (680 aa)
ABCD2ATP binding cassette subfamily D member 2. (740 aa)
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (381 aa)
ACAD11Acyl-CoA dehydrogenase family member 11. (755 aa)
ACAA1Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (424 aa)
PEX3Peroxisomal biogenesis factor 3. (373 aa)
ATMATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2635 aa)
ENSPCOP00000017312Uncharacterized protein. (461 aa)
LOC105821449Uncharacterized protein. (111 aa)
MPV17LUncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family. (196 aa)
SERHL2Serine hydrolase like 2. (267 aa)
LOC1058206495-hydroxyisourate hydrolase; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. (118 aa)
PEX11GPeroxisomal biogenesis factor 11 gamma. (237 aa)
ACBD4Acyl-CoA binding domain containing 4. (320 aa)
MGST1Microsomal glutathione S-transferase 1. (155 aa)
GSTK1Glutathione S-transferase kappa. (226 aa)
HACL12-hydroxyacyl-CoA lyase 1; Belongs to the TPP enzyme family. (567 aa)
IDI1Nudix hydrolase domain-containing protein. (280 aa)
MPV17Mitochondrial inner membrane protein MPV17; Belongs to the peroxisomal membrane protein PXMP2/4 family. (176 aa)
ACSL1Acyl-CoA synthetase long chain family member 1. (664 aa)
PEX12Peroxisome assembly protein 12; Required for protein import into peroxisomes. Belongs to the pex2/pex10/pex12 family. (359 aa)
PEX11BUncharacterized protein. (259 aa)
AGPSAlkylglycerone-phosphate synthase; Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids; Belongs to the FAD-binding oxidoreductase/transferase type 4 family. (535 aa)
PNPLA8Patatin like phospholipase domain containing 8. (614 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (352 aa)
IDEInsulin degrading enzyme; Belongs to the peptidase M16 family. (1026 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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