node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
F12 | F2 | ENSPCOP00000010528 | ENSPCOP00000013453 | Coagulation factor XII. | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | 0.794 |
F12 | HABP2 | ENSPCOP00000010528 | ENSPCOP00000001621 | Coagulation factor XII. | Hyaluronan binding protein 2. | 0.672 |
F12 | HGF | ENSPCOP00000010528 | ENSPCOP00000018290 | Coagulation factor XII. | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. | 0.761 |
F12 | HGFAC | ENSPCOP00000010528 | ENSPCOP00000005222 | Coagulation factor XII. | HGF activator. | 0.638 |
F12 | MST1 | ENSPCOP00000010528 | ENSPCOP00000001700 | Coagulation factor XII. | Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. | 0.773 |
F12 | PLAT | ENSPCOP00000010528 | ENSPCOP00000007546 | Coagulation factor XII. | Plasminogen activator; Belongs to the peptidase S1 family. | 0.538 |
F12 | PLAU | ENSPCOP00000010528 | ENSPCOP00000027063 | Coagulation factor XII. | Plasminogen activator, urokinase. | 0.531 |
F12 | PLG | ENSPCOP00000010528 | ENSPCOP00000027573 | Coagulation factor XII. | Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] | 0.944 |
F12 | PRSS12 | ENSPCOP00000010528 | ENSPCOP00000026941 | Coagulation factor XII. | Serine protease 12; Belongs to the peptidase S1 family. | 0.553 |
F12 | ROR1 | ENSPCOP00000010528 | ENSPCOP00000005538 | Coagulation factor XII. | Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. | 0.662 |
F12 | ROR2 | ENSPCOP00000010528 | ENSPCOP00000012277 | Coagulation factor XII. | Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. | 0.662 |
F2 | F12 | ENSPCOP00000013453 | ENSPCOP00000010528 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Coagulation factor XII. | 0.794 |
F2 | HABP2 | ENSPCOP00000013453 | ENSPCOP00000001621 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Hyaluronan binding protein 2. | 0.559 |
F2 | HGF | ENSPCOP00000013453 | ENSPCOP00000018290 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. | 0.440 |
F2 | HGFAC | ENSPCOP00000013453 | ENSPCOP00000005222 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | HGF activator. | 0.687 |
F2 | MST1 | ENSPCOP00000013453 | ENSPCOP00000001700 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. | 0.438 |
F2 | PLAT | ENSPCOP00000013453 | ENSPCOP00000007546 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Plasminogen activator; Belongs to the peptidase S1 family. | 0.509 |
F2 | PLAU | ENSPCOP00000013453 | ENSPCOP00000027063 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Plasminogen activator, urokinase. | 0.427 |
F2 | PLG | ENSPCOP00000013453 | ENSPCOP00000027573 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] | 0.944 |
HABP2 | F12 | ENSPCOP00000001621 | ENSPCOP00000010528 | Hyaluronan binding protein 2. | Coagulation factor XII. | 0.672 |