STRINGSTRING
NTRK2 NTRK2 TGFBR2 TGFBR2 TYK2 TYK2 FGFR1 FGFR1 SIK2 SIK2 MERTK MERTK JAK3 JAK3 TESK1 TESK1 KDR KDR RAF1 RAF1 ROR1 ROR1 ENSPCOP00000005631 ENSPCOP00000005631 ALK ALK BLK BLK TEC TEC STK26 STK26 FYN FYN TEK TEK TESK2 TESK2 SYK SYK FLT4 FLT4 LCK LCK EPHA2 EPHA2 FRK FRK TNK1 TNK1 NTRK1 NTRK1 PRKX PRKX ENSPCOP00000011171 ENSPCOP00000011171 NEK7 NEK7 ARAF ARAF NPR1 NPR1 HCK HCK NRK NRK BMPR1A BMPR1A ROR2 ROR2 EPHA4 EPHA4 PTK7 PTK7 MATK MATK RYK RYK EPHB6 EPHB6 JAK1 JAK1 ROS1 ROS1 FER FER EPHB1 EPHB1 ILK ILK BMPR1B BMPR1B MLKL MLKL ACVR1 ACVR1 FLT1 FLT1 DDR1 DDR1 LIMK1 LIMK1 EPHA3 EPHA3 ACVR1C ACVR1C MST1R MST1R TNK2 TNK2 AXL AXL RET RET KIT KIT LTK LTK RIPK1 RIPK1 SRMS SRMS FLT3 FLT3 KSR1 KSR1 LMTK3 LMTK3 BRAF BRAF RIPK2 RIPK2 LYN LYN GUCY2F GUCY2F INSR INSR PTK2 PTK2 LMTK2 LMTK2 EPHA1 EPHA1 PDGFRA PDGFRA TYRO3 TYRO3 CSF1R CSF1R ZAP70 ZAP70 GUCY2D GUCY2D BMX BMX POMK POMK STYK1 STYK1 ERBB3 ERBB3 NTRK3 NTRK3 LIMK2 LIMK2 PTK2B PTK2B FGFR3 FGFR3 ERBB2 ERBB2 FGFR4 FGFR4 IRAK4 IRAK4 MAP3K20 MAP3K20 MAP3K21 MAP3K21 MAP3K13 MAP3K13 TXK TXK MAP3K12 MAP3K12 MAP3K11 MAP3K11 ENSPCOP00000029403 ENSPCOP00000029403 BTK BTK FGFR2 FGFR2 CSK CSK MAP3K10 MAP3K10 PDGFRB PDGFRB TNNI3K TNNI3K RIPK3 RIPK3 FES FES TEX14 TEX14 ITK ITK ABL1 ABL1 SCYL3 SCYL3 NRBP1 NRBP1 EPHB2 EPHB2 ENSPCOP00000000722 ENSPCOP00000000722 NPR2 NPR2 ACVRL1 ACVRL1 AATK AATK MUSK MUSK MET MET IGF1R IGF1R EPHB4 EPHB4 IRAK3 IRAK3 KSR2 KSR2 MAP3K9 MAP3K9 NEK6 NEK6 EPHB3 EPHB3 INSRR INSRR DDR2 DDR2 SRC SRC FGR FGR EGFR EGFR ABL2 ABL2 EPHA8 EPHA8 EPHA10 EPHA10 TIE1 TIE1 GUCY2C GUCY2C
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NTRK2Tyrosine-protein kinase receptor. (838 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
TYK2Tyrosine-protein kinase. (1181 aa)
FGFR1Fibroblast growth factor receptor. (846 aa)
SIK2Salt inducible kinase 2. (890 aa)
MERTKMER proto-oncogene, tyrosine kinase. (998 aa)
JAK3Tyrosine-protein kinase. (1123 aa)
TESK1Testis associated actin remodelling kinase 1. (628 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
ROR1Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (937 aa)
ENSPCOP00000005631Protein kinase domain-containing protein. (159 aa)
ALKTyrosine-protein kinase receptor. (1578 aa)
BLKTyrosine-protein kinase. (500 aa)
TECTyrosine-protein kinase. (625 aa)
STK26Serine/threonine kinase 26. (372 aa)
FYNTyrosine-protein kinase. (537 aa)
TEKTEK receptor tyrosine kinase. (1125 aa)
TESK2Testis associated actin remodelling kinase 2. (573 aa)
SYKSpleen associated tyrosine kinase. (637 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1341 aa)
LCKTyrosine-protein kinase. (417 aa)
EPHA2EPH receptor A2. (976 aa)
FRKTyrosine-protein kinase. (508 aa)
TNK1Tyrosine kinase non receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (662 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
PRKXUncharacterized protein; Belongs to the protein kinase superfamily. (297 aa)
ENSPCOP00000011171Uncharacterized protein. (575 aa)
NEK7NIMA related kinase 7; Belongs to the protein kinase superfamily. (302 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (609 aa)
NPR1Guanylate cyclase. (1058 aa)
HCKTyrosine-protein kinase. (524 aa)
NRKNik related kinase. (1565 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (484 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (943 aa)
EPHA4EPH receptor A4. (976 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1072 aa)
MATKTyrosine-protein kinase. (507 aa)
RYKReceptor like tyrosine kinase. (606 aa)
EPHB6EPH receptor B6. (1019 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
ROS1Tyrosine-protein kinase receptor. (2630 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
EPHB1EPH receptor B1. (984 aa)
ILKIntegrin linked kinase. (518 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (500 aa)
MLKLMixed lineage kinase domain like pseudokinase. (419 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (913 aa)
LIMK1LIM domain kinase 1. (678 aa)
EPHA3EPH receptor A3. (831 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (484 aa)
MST1RMacrophage stimulating 1 receptor. (1403 aa)
TNK2Tyrosine kinase non receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1088 aa)
AXLAXL receptor tyrosine kinase. (894 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1079 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
LTKTyrosine-protein kinase receptor. (888 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (643 aa)
SRMSTyrosine-protein kinase. (496 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (949 aa)
KSR1Kinase suppressor of ras 1. (849 aa)
LMTK3Lemur tyrosine kinase 3. (1466 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (745 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (539 aa)
LYNTyrosine-protein kinase. (512 aa)
GUCY2FGuanylate cyclase. (1108 aa)
INSRInsulin receptor. (1192 aa)
PTK2Protein tyrosine kinase 2. (1089 aa)
LMTK2Lemur tyrosine kinase 2. (1466 aa)
EPHA1EPH receptor A1. (942 aa)
PDGFRAPlatelet derived growth factor receptor alpha; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1027 aa)
TYRO3TYRO3 protein tyrosine kinase. (896 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (964 aa)
ZAP70Tyrosine-protein kinase. (617 aa)
GUCY2DGuanylate cyclase. (1100 aa)
BMXTyrosine-protein kinase. (627 aa)
POMKProtein O-mannose kinase. (350 aa)
STYK1Serine/threonine/tyrosine kinase 1. (404 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1337 aa)
NTRK3Tyrosine-protein kinase receptor. (865 aa)
LIMK2LIM domain kinase 2. (638 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (967 aa)
FGFR3Fibroblast growth factor receptor. (807 aa)
ERBB2Receptor protein-tyrosine kinase. (1252 aa)
FGFR4Fibroblast growth factor receptor. (797 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (406 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20. (800 aa)
MAP3K21Mitogen-activated protein kinase kinase kinase. (1038 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13. (958 aa)
TXKTyrosine-protein kinase. (581 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (891 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase. (847 aa)
ENSPCOP00000029403Protein kinase domain-containing protein. (429 aa)
BTKTyrosine-protein kinase. (647 aa)
FGFR2Fibroblast growth factor receptor. (797 aa)
CSKTyrosine-protein kinase. (450 aa)
MAP3K10Mitogen-activated protein kinase kinase kinase. (959 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1105 aa)
TNNI3KUncharacterized protein. (724 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (516 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (821 aa)
TEX14Testis expressed 14, intercellular bridge forming factor. (1451 aa)
ITKTyrosine-protein kinase. (598 aa)
ABL1Tyrosine-protein kinase. (1146 aa)
SCYL3SCY1 like pseudokinase 3. (731 aa)
NRBP1Nuclear receptor binding protein 1. (543 aa)
EPHB2EPH receptor B2. (1039 aa)
ENSPCOP00000000722Protein kinase domain-containing protein. (67 aa)
NPR2Guanylate cyclase. (1047 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa)
AATKApoptosis associated tyrosine kinase. (1335 aa)
MUSKMuscle associated receptor tyrosine kinase. (826 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1397 aa)
IGF1RTyrosine-protein kinase receptor. (1350 aa)
EPHB4EPH receptor B4. (987 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (505 aa)
KSR2Kinase suppressor of ras 2. (880 aa)
MAP3K9Mitogen-activated protein kinase kinase kinase. (1103 aa)
NEK6NIMA related kinase 6; Belongs to the protein kinase superfamily. (313 aa)
EPHB3EPH receptor B3. (1009 aa)
INSRRTyrosine-protein kinase receptor. (1272 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
SRCTyrosine-protein kinase. (543 aa)
FGRTyrosine-protein kinase. (495 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
ABL2Tyrosine-protein kinase. (1154 aa)
EPHA8EPH receptor A8. (1006 aa)
EPHA10EPH receptor A10. (1008 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1143 aa)
GUCY2CGuanylate cyclase. (982 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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