(50 nodes) Cytochrome P450, E-class, group I network (Propithecus coquereli)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TBXAS1	Thromboxane A synthase 1; Belongs to the cytochrome P450 family. (573 aa)
	CYP4X1	Cytochrome P450 family 4 subfamily X member 1; Belongs to the cytochrome P450 family. (509 aa)
	CYP19A1	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa)
	ENSPCOP00000017289	Uncharacterized protein. (430 aa)
	CYP1A2	Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. (516 aa)
	LOC105806372	Uncharacterized protein; Belongs to the cytochrome P450 family. (502 aa)
	CYP2F1	Cytochrome P450 family 2 subfamily F member 1; Belongs to the cytochrome P450 family. (491 aa)
	ENSPCOP00000000410	Uncharacterized protein. (163 aa)
	CYP17A1	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family. (508 aa)
	LOC105820607	Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
	LOC105820536	Uncharacterized protein. (494 aa)
	CYP2E1	Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family. (493 aa)
	LOC105825741	Uncharacterized protein; Belongs to the cytochrome P450 family. (524 aa)
	CYP24A1	Cytochrome P450 family 24 subfamily A member 1; Belongs to the cytochrome P450 family. (514 aa)
	LOC105808026	Uncharacterized protein. (472 aa)
	LOC105810118	Uncharacterized protein; Belongs to the cytochrome P450 family. (199 aa)
	LOC105806023	Uncharacterized protein; Belongs to the cytochrome P450 family. (466 aa)
	CYP2R1	Cytochrome P450 family 2 subfamily R member 1. (443 aa)
	LOC105827104	Uncharacterized protein; Belongs to the cytochrome P450 family. (524 aa)
	CYP4F163	Uncharacterized protein; Belongs to the cytochrome P450 family. (201 aa)
	CYP1A1	Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. (516 aa)
	LOC105825739	Uncharacterized protein; Belongs to the cytochrome P450 family. (199 aa)
	LOC105813360	Uncharacterized protein; Belongs to the cytochrome P450 family. (452 aa)
	LOC105813307	Uncharacterized protein; Belongs to the cytochrome P450 family. (400 aa)
	LOC105806815	Uncharacterized protein; Belongs to the cytochrome P450 family. (284 aa)
	CYP4F22	Cytochrome P450 family 4 subfamily F member 22; Belongs to the cytochrome P450 family. (531 aa)
	CYP11A1	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (521 aa)
	CYP27A1	Cytochrome P450 family 27 subfamily A member 1; Belongs to the cytochrome P450 family. (530 aa)
	CYP27C1	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (372 aa)
	CYP4B1	Cytochrome P450 family 4 subfamily B member 1; Belongs to the cytochrome P450 family. (511 aa)
	LOC105822723	Uncharacterized protein; Belongs to the cytochrome P450 family. (490 aa)
	CYP4F153	Uncharacterized protein; Belongs to the cytochrome P450 family. (463 aa)
	CYP2W1	Cytochrome P450 family 2 subfamily W member 1; Belongs to the cytochrome P450 family. (490 aa)
	LOC105814130	Uncharacterized protein; Belongs to the cytochrome P450 family. (519 aa)
	CYP1B1	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa)
	LOC105820597	Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
	CYP4V2	Cytochrome P450 family 4 subfamily V member 2; Belongs to the cytochrome P450 family. (525 aa)
	ENSPCOP00000025098	Uncharacterized protein. (468 aa)
	CYP2S1	Cytochrome P450 family 2 subfamily S member 1; Belongs to the cytochrome P450 family. (503 aa)
	CYP20A1	Cytochrome P450 family 20 subfamily A member 1. (432 aa)
	CYP21A2	Cytochrome P450 family 21 subfamily A member 2; Belongs to the cytochrome P450 family. (494 aa)
	CYP4F155	Uncharacterized protein; Belongs to the cytochrome P450 family. (454 aa)
	LOC105820598	Uncharacterized protein; Belongs to the cytochrome P450 family. (483 aa)
	LOC105806374	Uncharacterized protein; Belongs to the cytochrome P450 family. (502 aa)
	CYP2U1	Cytochrome P450 family 2 subfamily U member 1; Belongs to the cytochrome P450 family. (335 aa)
	CYP46A1	Cytochrome P450 family 46 subfamily A member 1; Belongs to the cytochrome P450 family. (471 aa)
	ENSPCOP00000031076	Uncharacterized protein; Belongs to the cytochrome P450 family. (514 aa)
	LOC105820478	Uncharacterized protein. (471 aa)
	LOC105805151	Uncharacterized protein. (268 aa)
	CYP27B1	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)

Your Current Organism:

Propithecus coquereli

NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYP11A1	CYP17A1	ENSPCOP00000012029	ENSPCOP00000001171	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family.	0.919
CYP11A1	CYP19A1	ENSPCOP00000012029	ENSPCOP00000019214	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	0.811
CYP11A1	CYP1A1	ENSPCOP00000012029	ENSPCOP00000007648	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family.	0.450
CYP11A1	CYP1A2	ENSPCOP00000012029	ENSPCOP00000016903	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family.	0.452
CYP11A1	CYP1B1	ENSPCOP00000012029	ENSPCOP00000022093	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family.	0.418
CYP11A1	CYP21A2	ENSPCOP00000012029	ENSPCOP00000027244	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 family 21 subfamily A member 2; Belongs to the cytochrome P450 family.	0.916
CYP11A1	CYP27A1	ENSPCOP00000012029	ENSPCOP00000011844	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 family 27 subfamily A member 1; Belongs to the cytochrome P450 family.	0.623
CYP11A1	CYP27B1	ENSPCOP00000012029	ENSPCOP00000019752	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family.	0.604
CYP11A1	CYP27C1	ENSPCOP00000012029	ENSPCOP00000011345	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family.	0.600
CYP11A1	CYP2E1	ENSPCOP00000012029	ENSPCOP00000003449	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family.	0.454
CYP11A1	CYP2F1	ENSPCOP00000012029	ENSPCOP00000000181	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 family 2 subfamily F member 1; Belongs to the cytochrome P450 family.	0.411
CYP11A1	CYP2R1	ENSPCOP00000012029	ENSPCOP00000012325	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 family 2 subfamily R member 1.	0.782
CYP11A1	CYP2S1	ENSPCOP00000012029	ENSPCOP00000025157	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 family 2 subfamily S member 1; Belongs to the cytochrome P450 family.	0.401
CYP11A1	CYP2W1	ENSPCOP00000012029	ENSPCOP00000020161	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 family 2 subfamily W member 1; Belongs to the cytochrome P450 family.	0.454
CYP11A1	CYP46A1	ENSPCOP00000012029	ENSPCOP00000030865	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 family 46 subfamily A member 1; Belongs to the cytochrome P450 family.	0.802
CYP11A1	CYP4B1	ENSPCOP00000012029	ENSPCOP00000010873	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 family 4 subfamily B member 1; Belongs to the cytochrome P450 family.	0.447
CYP11A1	CYP4F153	ENSPCOP00000012029	ENSPCOP00000014973	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.445
CYP11A1	CYP4F155	ENSPCOP00000012029	ENSPCOP00000027687	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.445
CYP11A1	CYP4F163	ENSPCOP00000012029	ENSPCOP00000007175	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.405
CYP11A1	CYP4F22	ENSPCOP00000012029	ENSPCOP00000010627	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 family 4 subfamily F member 22; Belongs to the cytochrome P450 family.	0.452