(17 nodes) Furin-like repeat network (Propithecus coquereli)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RSPO3	R-spondin 3. (262 aa)
	RSPO2	R-spondin 2. (243 aa)
	RSPO4	R-spondin 4. (233 aa)
	ERBB3	Erb-b2 receptor tyrosine kinase 3. (1337 aa)
	CRELD1	Cysteine rich with EGF like domains 1. (420 aa)
	INSR	Insulin receptor. (1192 aa)
	PCSK4	Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (757 aa)
	PCSK6	Proprotein convertase subtilisin/kexin type 6; Belongs to the peptidase S8 family. (961 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1350 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1252 aa)
	FRAS1	Fraser extracellular matrix complex subunit 1. (3561 aa)
	INSRR	Tyrosine-protein kinase receptor. (1272 aa)
	EGFR	Receptor protein-tyrosine kinase. (1210 aa)
	RSPO1	R-spondin 1. (266 aa)
	CRELD2	Cysteine rich with EGF like domains 2. (356 aa)
	PCSK5	Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1858 aa)
	FURIN	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (798 aa)

Your Current Organism:

Propithecus coquereli

NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGFR	ERBB2	ENSPCOP00000018322	ENSPCOP00000028204	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.999
EGFR	ERBB3	ENSPCOP00000018322	ENSPCOP00000027625	Receptor protein-tyrosine kinase.	Erb-b2 receptor tyrosine kinase 3.	0.997
EGFR	IGF1R	ENSPCOP00000018322	ENSPCOP00000021856	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.959
EGFR	INSR	ENSPCOP00000018322	ENSPCOP00000025685	Receptor protein-tyrosine kinase.	Insulin receptor.	0.900
EGFR	INSRR	ENSPCOP00000018322	ENSPCOP00000018723	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.815
ERBB2	EGFR	ENSPCOP00000028204	ENSPCOP00000018322	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.999
ERBB2	ERBB3	ENSPCOP00000028204	ENSPCOP00000027625	Receptor protein-tyrosine kinase.	Erb-b2 receptor tyrosine kinase 3.	0.999
ERBB2	IGF1R	ENSPCOP00000028204	ENSPCOP00000021856	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.968
ERBB2	INSR	ENSPCOP00000028204	ENSPCOP00000025685	Receptor protein-tyrosine kinase.	Insulin receptor.	0.928
ERBB2	INSRR	ENSPCOP00000028204	ENSPCOP00000018723	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.869
ERBB3	EGFR	ENSPCOP00000027625	ENSPCOP00000018322	Erb-b2 receptor tyrosine kinase 3.	Receptor protein-tyrosine kinase.	0.997
ERBB3	ERBB2	ENSPCOP00000027625	ENSPCOP00000028204	Erb-b2 receptor tyrosine kinase 3.	Receptor protein-tyrosine kinase.	0.999
ERBB3	IGF1R	ENSPCOP00000027625	ENSPCOP00000021856	Erb-b2 receptor tyrosine kinase 3.	Tyrosine-protein kinase receptor.	0.821
ERBB3	INSR	ENSPCOP00000027625	ENSPCOP00000025685	Erb-b2 receptor tyrosine kinase 3.	Insulin receptor.	0.653
ERBB3	INSRR	ENSPCOP00000027625	ENSPCOP00000018723	Erb-b2 receptor tyrosine kinase 3.	Tyrosine-protein kinase receptor.	0.653
FRAS1	FURIN	ENSPCOP00000019280	ENSPCOP00000011730	Fraser extracellular matrix complex subunit 1.	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	0.448
FRAS1	PCSK4	ENSPCOP00000019280	ENSPCOP00000024703	Fraser extracellular matrix complex subunit 1.	Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family.	0.421
FURIN	FRAS1	ENSPCOP00000011730	ENSPCOP00000019280	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	Fraser extracellular matrix complex subunit 1.	0.448
FURIN	RSPO4	ENSPCOP00000011730	ENSPCOP00000030289	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	R-spondin 4.	0.424
IGF1R	EGFR	ENSPCOP00000021856	ENSPCOP00000018322	Tyrosine-protein kinase receptor.	Receptor protein-tyrosine kinase.	0.959