56 items (Propithecus coquereli) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	PIWIL2	Piwi like RNA-mediated gene silencing 2; Belongs to the argonaute family. (971 aa)
	EXD1	Exonuclease 3'-5' domain containing 1. (552 aa)
	CNOT8	CCR4-NOT transcription complex subunit 8. (292 aa)
	KIAA1586	KIAA1586. (787 aa)
	PNLDC1	PARN like, ribonuclease domain containing 1. (531 aa)
	ZBED8	Zinc finger BED-type containing 8. (594 aa)
	REXO4	REX4 homolog, 3'-5' exonuclease. (419 aa)
	ESRP1	Epithelial splicing regulatory protein 1. (677 aa)
	SPEF2	Sperm flagellar 2. (1865 aa)
	GTF2IRD2B	Uncharacterized protein. (948 aa)
	AGO2	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (869 aa)
	TREX2	Three prime repair exonuclease 2. (277 aa)
	PAN2	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1198 aa)
	REXO5	RNA exonuclease 5. (775 aa)
	REV3L	REV3 like, DNA directed polymerase zeta catalytic subunit. (3120 aa)
	POLE	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2284 aa)
	ERI1	Exoribonuclease 1. (348 aa)
	POLD1	DNA polymerase. (1125 aa)
	PARN	Poly(A)-specific ribonuclease. (623 aa)
	ZNF618	Zinc finger protein 618. (954 aa)
	CNOT7	Uncharacterized protein. (303 aa)
	EXOSC10	Exosome component 10. (878 aa)
	PRPF8	Pre-mRNA processing factor 8. (2335 aa)
	ZMYM1	Zinc finger MYM-type containing 1. (1138 aa)
	ISG20	Interferon stimulated exonuclease gene 20. (174 aa)
	AGO4	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (855 aa)
	RNASEH1	Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (266 aa)
	REXO1	RNA exonuclease 1 homolog. (1219 aa)
	AEN	Apoptosis enhancing nuclease. (325 aa)
	ERI3	ERI1 exoribonuclease family member 3. (337 aa)
	SUPT6H	Transcription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1710 aa)
	AGO1	Argonaute RISC component 1; Belongs to the argonaute family. (857 aa)
	PIWIL4	Piwi like RNA-mediated gene silencing 4; Belongs to the argonaute family. (851 aa)
	TEFM	Transcription elongation factor, mitochondrial. (359 aa)
	POLG	DNA polymerase gamma, catalytic subunit. (1224 aa)
	WRN	WRN RecQ like helicase. (1049 aa)
	PIWIL1	Piwi like RNA-mediated gene silencing 1; Belongs to the argonaute family. (849 aa)
	LOC105822732	Uncharacterized protein. (245 aa)
	RNASEH2A	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (300 aa)
	TOE1	Target of EGR1, exonuclease. (507 aa)
	ZBED5	Zinc finger BED-type containing 5. (693 aa)
	ERI2	ERI1 exoribonuclease family member 2. (685 aa)
	ESRP2	Epithelial splicing regulatory protein 2. (715 aa)
	GIN1	Gypsy retrotransposon integrase 1. (522 aa)
	ISG20L2	Interferon stimulated exonuclease gene 20 like 2. (349 aa)
	KRBA2	KRAB-A domain containing 2. (479 aa)
	POLA1	DNA polymerase. (1442 aa)
	SRBD1	S1 RNA binding domain 1. (949 aa)
	EXD2	Exonuclease 3'-5' domain containing 2. (621 aa)
	ZBED9	Zinc finger BED-type containing 9. (1326 aa)
	ZMYM6	Zinc finger MYM-type containing 6. (1324 aa)
	AGO3	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa)
	ZNF862	Zinc finger protein 862. (1170 aa)
	NYNRIN	NYN domain and retroviral integrase containing. (1898 aa)
	REXO2	RNA exonuclease 2. (195 aa)
	LOC105811802	Uncharacterized protein. (249 aa)

Your Current Organism:

Propithecus coquereli

NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AEN	EXOSC10	ENSPCOP00000018109	ENSPCOP00000005591	Apoptosis enhancing nuclease.	Exosome component 10.	0.703
AEN	REXO2	ENSPCOP00000018109	ENSPCOP00000029855	Apoptosis enhancing nuclease.	RNA exonuclease 2.	0.739
AEN	RNASEH1	ENSPCOP00000018109	ENSPCOP00000015414	Apoptosis enhancing nuclease.	Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.	0.581
AGO1	AGO2	ENSPCOP00000020215	ENSPCOP00000022017	Argonaute RISC component 1; Belongs to the argonaute family.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.991
AGO1	AGO3	ENSPCOP00000020215	ENSPCOP00000031265	Argonaute RISC component 1; Belongs to the argonaute family.	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.918
AGO1	AGO4	ENSPCOP00000020215	ENSPCOP00000009174	Argonaute RISC component 1; Belongs to the argonaute family.	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.805
AGO1	ERI1	ENSPCOP00000020215	ENSPCOP00000014778	Argonaute RISC component 1; Belongs to the argonaute family.	Exoribonuclease 1.	0.467
AGO2	AGO1	ENSPCOP00000022017	ENSPCOP00000020215	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Argonaute RISC component 1; Belongs to the argonaute family.	0.991
AGO2	AGO3	ENSPCOP00000022017	ENSPCOP00000031265	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.989
AGO2	AGO4	ENSPCOP00000022017	ENSPCOP00000009174	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.967
AGO2	CNOT7	ENSPCOP00000022017	ENSPCOP00000028559	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Uncharacterized protein.	0.499
AGO2	ERI1	ENSPCOP00000022017	ENSPCOP00000014778	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Exoribonuclease 1.	0.467
AGO2	LOC105811802	ENSPCOP00000022017	ENSPCOP00000029769	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Uncharacterized protein.	0.499
AGO2	LOC105822732	ENSPCOP00000022017	ENSPCOP00000002477	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Uncharacterized protein.	0.499
AGO3	AGO1	ENSPCOP00000031265	ENSPCOP00000020215	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Argonaute RISC component 1; Belongs to the argonaute family.	0.918
AGO3	AGO2	ENSPCOP00000031265	ENSPCOP00000022017	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.989
AGO3	AGO4	ENSPCOP00000031265	ENSPCOP00000009174	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.835
AGO3	ERI1	ENSPCOP00000031265	ENSPCOP00000014778	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Exoribonuclease 1.	0.467
AGO4	AGO1	ENSPCOP00000009174	ENSPCOP00000020215	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Argonaute RISC component 1; Belongs to the argonaute family.	0.805
AGO4	AGO2	ENSPCOP00000009174	ENSPCOP00000022017	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.967