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ITK ITK SH2D1B SH2D1B RIN3 RIN3 RASA1 RASA1 NCK1 NCK1 LOC105815528 LOC105815528 SHB SHB SH2B1 SH2B1 TYK2 TYK2 NCK2 NCK2 SOCS4 SOCS4 SLA SLA SOCS1 SOCS1 JAK3 JAK3 SOCS5 SOCS5 SLA2 SLA2 SH2D7 SH2D7 SH3BP2 SH3BP2 BLK BLK STAT6 STAT6 LOC105807014 LOC105807014 TEC TEC SH2D2A SH2D2A GRB7 GRB7 SHC4 SHC4 VAV2 VAV2 STAT1 STAT1 STAP1 STAP1 SH2D5 SH2D5 PIK3R3 PIK3R3 LOC105825304 LOC105825304 FYN FYN CHN2 CHN2 SYK SYK LCK LCK STAT2 STAT2 ENSPCOP00000010513 ENSPCOP00000010513 FRK FRK INPPL1 INPPL1 CBL CBL HCK HCK PLCG2 PLCG2 SH2D1A SH2D1A MATK MATK ABL1 ABL1 GRAP GRAP JAK1 JAK1 INPP5D INPP5D PTPN6 PTPN6 SHC2 SHC2 SH2D3A SH2D3A FER FER CHN1 CHN1 TNS3 TNS3 VAV1 VAV1 SH2B2 SH2B2 GRB10 GRB10 GRB14 GRB14 GRB2 GRB2 ABL2 ABL2 CRK CRK PIK3R2 PIK3R2 FGR FGR PIK3R1 PIK3R1 SRC SRC SH2D3C SH2D3C SUPT6H SUPT6H VAV3 VAV3 ENSPCOP00000019392 ENSPCOP00000019392 SHC3 SHC3 STAP2 STAP2 CBLC CBLC LCP2 LCP2 DAPP1 DAPP1 BCAR3 BCAR3 RIN2 RIN2 CBLB CBLB STAT5A STAT5A CLNK CLNK SHD SHD SOCS7 SOCS7 TNS4 TNS4 SRMS SRMS SHE SHE BLNK BLNK PLCG1 PLCG1 LYN LYN STAT5B STAT5B SOCS6 SOCS6 ZAP70 ZAP70 BMX BMX SOCS3 SOCS3 SH2D4A SH2D4A STAT4 STAT4 TNS2 TNS2 TXK TXK SH2B3 SH2B3 PTPN11 PTPN11 BTK BTK SH2D6 SH2D6 RIN1 RIN1 CRKL CRKL GRAP2 GRAP2 STAT3 STAT3 CSK CSK CISH CISH FES FES SHF SHF SHC1 SHC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITKTyrosine-protein kinase. (598 aa)
SH2D1BSH2 domain containing 1B. (131 aa)
RIN3Ras and Rab interactor 3. (981 aa)
RASA1RAS p21 protein activator 1. (623 aa)
NCK1Cytoplasmic protein. (377 aa)
LOC105815528Uncharacterized protein. (461 aa)
SHBSH2 domain-containing protein. (509 aa)
SH2B1SH2B adaptor protein 1. (757 aa)
TYK2Tyrosine-protein kinase. (1181 aa)
NCK2Cytoplasmic protein. (380 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
SLASrc like adaptor. (314 aa)
SOCS1Suppressor of cytokine signaling 1. (223 aa)
JAK3Tyrosine-protein kinase. (1123 aa)
SOCS5Uncharacterized protein. (536 aa)
SLA2Src like adaptor 2. (269 aa)
SH2D7SH2 domain containing 7. (432 aa)
SH3BP2SH3 domain binding protein 2. (612 aa)
BLKTyrosine-protein kinase. (500 aa)
STAT6Signal transducer and activator of transcription. (846 aa)
LOC105807014Uncharacterized protein. (652 aa)
TECTyrosine-protein kinase. (625 aa)
SH2D2ASH2 domain containing 2A. (378 aa)
GRB7Growth factor receptor bound protein 7. (531 aa)
SHC4SHC adaptor protein 4. (630 aa)
VAV2Vav guanine nucleotide exchange factor 2. (771 aa)
STAT1Signal transducer and activator of transcription. (794 aa)
STAP1Signal transducing adaptor family member 1. (227 aa)
SH2D5SH2 domain containing 5. (428 aa)
PIK3R3Uncharacterized protein. (454 aa)
LOC105825304SH2 domain-containing protein. (1362 aa)
FYNTyrosine-protein kinase. (537 aa)
CHN2Chimaerin; GTPase-activating protein for p21-rac. (468 aa)
SYKSpleen associated tyrosine kinase. (637 aa)
LCKTyrosine-protein kinase. (417 aa)
STAT2Signal transducer and activator of transcription. (862 aa)
ENSPCOP00000010513SH2 domain-containing protein. (85 aa)
FRKTyrosine-protein kinase. (508 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1264 aa)
CBLCbl proto-oncogene. (891 aa)
HCKTyrosine-protein kinase. (524 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1233 aa)
SH2D1ASH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. (128 aa)
MATKTyrosine-protein kinase. (507 aa)
ABL1Tyrosine-protein kinase. (1146 aa)
GRAPGRB2 related adaptor protein. (217 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1178 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (607 aa)
SHC2Uncharacterized protein. (578 aa)
SH2D3ASH2 domain containing 3A. (577 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
CHN1Chimaerin; GTPase-activating protein for p21-rac. (459 aa)
TNS3Tensin 3. (1446 aa)
VAV1Vav guanine nucleotide exchange factor 1. (806 aa)
SH2B2Uncharacterized protein. (674 aa)
GRB10Growth factor receptor bound protein 10. (595 aa)
GRB14Growth factor receptor bound protein 14. (476 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
ABL2Tyrosine-protein kinase. (1154 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
PIK3R2Uncharacterized protein. (726 aa)
FGRTyrosine-protein kinase. (495 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
SRCTyrosine-protein kinase. (543 aa)
SH2D3CSH2 domain containing 3C. (860 aa)
SUPT6HTranscription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1710 aa)
VAV3Vav guanine nucleotide exchange factor 3. (765 aa)
ENSPCOP00000019392SOCS box domain-containing protein. (458 aa)
SHC3SHC adaptor protein 3. (596 aa)
STAP2Signal transducing adaptor family member 2. (410 aa)
CBLCCbl proto-oncogene C. (458 aa)
LCP2Lymphocyte cytosolic protein 2. (493 aa)
DAPP1Dual adaptor of phosphotyrosine and 3-phosphoinositides 1. (264 aa)
BCAR3BCAR3 adaptor protein, NSP family member. (823 aa)
RIN2Ras and Rab interactor 2. (924 aa)
CBLBCbl proto-oncogene B. (908 aa)
STAT5ASignal transducer and activator of transcription. (805 aa)
CLNKCytokine dependent hematopoietic cell linker. (420 aa)
SHDSrc homology 2 domain containing transforming protein D. (341 aa)
SOCS7Suppressor of cytokine signaling 7. (577 aa)
TNS4Tensin 4. (716 aa)
SRMSTyrosine-protein kinase. (496 aa)
SHESrc homology 2 domain containing E. (497 aa)
BLNKB cell linker. (421 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1304 aa)
LYNTyrosine-protein kinase. (512 aa)
STAT5BSignal transducer and activator of transcription. (667 aa)
SOCS6Uncharacterized protein. (535 aa)
ZAP70Tyrosine-protein kinase. (617 aa)
BMXTyrosine-protein kinase. (627 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
SH2D4ASH2 domain containing 4A. (454 aa)
STAT4Signal transducer and activator of transcription. (628 aa)
TNS2Tensin 2. (1415 aa)
TXKTyrosine-protein kinase. (581 aa)
SH2B3SH2B adaptor protein 3. (539 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
BTKTyrosine-protein kinase. (647 aa)
SH2D6Uncharacterized protein. (142 aa)
RIN1Ras and Rab interactor 1. (782 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
GRAP2GRB2 related adaptor protein 2. (326 aa)
STAT3Signal transducer and activator of transcription. (796 aa)
CSKTyrosine-protein kinase. (450 aa)
CISHCytokine inducible SH2 containing protein. (274 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (821 aa)
SHFSrc homology 2 domain containing F. (422 aa)
SHC1SHC adaptor protein 1. (582 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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