(22 nodes) AAA ATPase, AAA+ lid domain network (Propithecus coquereli)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

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Your Input:
	PSMC4	Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
	ATAD2B	ATPase family AAA domain containing 2B. (1327 aa)
	ATAD1	ATPase family AAA domain containing 1; Belongs to the AAA ATPase family. (383 aa)
	KATNA1	Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal p [...] (437 aa)
	ATAD2	ATPase family AAA domain containing 2. (1245 aa)
	VPS4B	Uncharacterized protein; Belongs to the AAA ATPase family. (443 aa)
	VCP	Valosin containing protein; Belongs to the AAA ATPase family. (806 aa)
	AFG3L2	AFG3 like matrix AAA peptidase subunit 2; Belongs to the AAA ATPase family. (640 aa)
	SPG7	SPG7 matrix AAA peptidase subunit, paraplegin. (761 aa)
	PSMC5	Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
	SPATA5	Spermatogenesis associated 5. (781 aa)
	YME1L1	YME1 like 1 ATPase; Belongs to the AAA ATPase family. (570 aa)
	VPS4A	Uncharacterized protein; Belongs to the AAA ATPase family. (504 aa)
	PEX1	Peroxisomal biogenesis factor 1. (1191 aa)
	SPATA5L1	Spermatogenesis associated 5 like 1. (751 aa)
	KATNAL2	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays. (476 aa)
	SPAST	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] (617 aa)
	PSMC2	AAA domain-containing protein; Belongs to the AAA ATPase family. (433 aa)
	PSMC3	Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (446 aa)
	NVL	Nuclear VCP like. (774 aa)
	LOC105820642	AAA domain-containing protein. (758 aa)
	KATNAL1	Katanin p60 ATPase-containing subunit A-like 1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neur [...] (445 aa)

Your Current Organism:

Propithecus coquereli

NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFG3L2	SPG7	ENSPCOP00000009703	ENSPCOP00000007708	AFG3 like matrix AAA peptidase subunit 2; Belongs to the AAA ATPase family.	SPG7 matrix AAA peptidase subunit, paraplegin.	0.885
AFG3L2	YME1L1	ENSPCOP00000009703	ENSPCOP00000003013	AFG3 like matrix AAA peptidase subunit 2; Belongs to the AAA ATPase family.	YME1 like 1 ATPase; Belongs to the AAA ATPase family.	0.528
ATAD1	ATAD2	ENSPCOP00000031363	ENSPCOP00000014610	ATPase family AAA domain containing 1; Belongs to the AAA ATPase family.	ATPase family AAA domain containing 2.	0.513
ATAD1	ATAD2B	ENSPCOP00000031363	ENSPCOP00000031312	ATPase family AAA domain containing 1; Belongs to the AAA ATPase family.	ATPase family AAA domain containing 2B.	0.513
ATAD1	KATNA1	ENSPCOP00000031363	ENSPCOP00000018042	ATPase family AAA domain containing 1; Belongs to the AAA ATPase family.	Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal p [...]	0.541
ATAD1	KATNAL1	ENSPCOP00000031363	ENSPCOP00000021211	ATPase family AAA domain containing 1; Belongs to the AAA ATPase family.	Katanin p60 ATPase-containing subunit A-like 1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neur [...]	0.539
ATAD1	KATNAL2	ENSPCOP00000031363	ENSPCOP00000005194	ATPase family AAA domain containing 1; Belongs to the AAA ATPase family.	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	0.599
ATAD1	PSMC2	ENSPCOP00000031363	ENSPCOP00000003252	ATPase family AAA domain containing 1; Belongs to the AAA ATPase family.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.541
ATAD1	PSMC3	ENSPCOP00000031363	ENSPCOP00000018041	ATPase family AAA domain containing 1; Belongs to the AAA ATPase family.	Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family.	0.568
ATAD1	PSMC4	ENSPCOP00000031363	ENSPCOP00000025519	ATPase family AAA domain containing 1; Belongs to the AAA ATPase family.	Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family.	0.563
ATAD1	PSMC5	ENSPCOP00000031363	ENSPCOP00000023893	ATPase family AAA domain containing 1; Belongs to the AAA ATPase family.	Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family.	0.540
ATAD1	VPS4A	ENSPCOP00000031363	ENSPCOP00000001961	ATPase family AAA domain containing 1; Belongs to the AAA ATPase family.	Uncharacterized protein; Belongs to the AAA ATPase family.	0.469
ATAD1	VPS4B	ENSPCOP00000031363	ENSPCOP00000014730	ATPase family AAA domain containing 1; Belongs to the AAA ATPase family.	Uncharacterized protein; Belongs to the AAA ATPase family.	0.465
ATAD2	ATAD1	ENSPCOP00000014610	ENSPCOP00000031363	ATPase family AAA domain containing 2.	ATPase family AAA domain containing 1; Belongs to the AAA ATPase family.	0.513
ATAD2	KATNAL2	ENSPCOP00000014610	ENSPCOP00000005194	ATPase family AAA domain containing 2.	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	0.564
ATAD2	NVL	ENSPCOP00000014610	ENSPCOP00000018489	ATPase family AAA domain containing 2.	Nuclear VCP like.	0.562
ATAD2	PEX1	ENSPCOP00000014610	ENSPCOP00000005294	ATPase family AAA domain containing 2.	Peroxisomal biogenesis factor 1.	0.513
ATAD2	PSMC3	ENSPCOP00000014610	ENSPCOP00000018041	ATPase family AAA domain containing 2.	Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family.	0.791
ATAD2	PSMC4	ENSPCOP00000014610	ENSPCOP00000025519	ATPase family AAA domain containing 2.	Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family.	0.791
ATAD2	SPAST	ENSPCOP00000014610	ENSPCOP00000003531	ATPase family AAA domain containing 2.	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...]	0.553