(34 nodes) Sm domain network (Propithecus coquereli)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

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	SNRPF	Small nuclear ribonucleoprotein polypeptide F. (86 aa)
	ENSPCOP00000001117	Small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. (74 aa)
	LSM8	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (96 aa)
	LOC105817235	Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. (118 aa)
	SNRPD1	Small nuclear ribonucleoprotein Sm D1; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA. (119 aa)
	EDC3	Enhancer of mRNA decapping 3. (508 aa)
	LSM14B	LSM family member 14B. (385 aa)
	SNRPB	Small nuclear ribonucleoprotein-associated protein. (231 aa)
	ENSPCOP00000005577	Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. (75 aa)
	ENSPCOP00000005730	Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. (102 aa)
	LSM6	LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated. (80 aa)
	LSM4-2	U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (115 aa)
	SNRPN	Small nuclear ribonucleoprotein-associated protein. (271 aa)
	LSM3-2	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (85 aa)
	ENSPCOP00000009233	Small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. (68 aa)
	LSM3	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (102 aa)
	ENSPCOP00000009677	TFG domain-containing protein. (334 aa)
	LSM7	LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated. (103 aa)
	LSM11	LSM11, U7 small nuclear RNA associated. (352 aa)
	LSM8-2	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (86 aa)
	LSM4	U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (139 aa)
	LSM2	U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (95 aa)
	NAA38	N(alpha)-acetyltransferase 38, NatC auxiliary subunit. (175 aa)
	LSM1	U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. (133 aa)
	ENSPCOP00000018460	Small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. (63 aa)
	SNRPE	Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. (74 aa)
	ATXN2	Ataxin 2. (1275 aa)
	LSM1-2	U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. (107 aa)
	LOC105811856	Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. (52 aa)
	ENSPCOP00000024485	Small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. (74 aa)
	ATXN2L	Ataxin 2 like. (1096 aa)
	ENSPCOP00000025981	Sm domain-containing protein. (74 aa)
	LSM12	LSM12 homolog. (195 aa)
	SNRPD3	Small nuclear ribonucleoprotein Sm D3; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing. (126 aa)

Your Current Organism:

Propithecus coquereli

NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATXN2	ATXN2L	ENSPCOP00000020175	ENSPCOP00000025142	Ataxin 2.	Ataxin 2 like.	0.891
ATXN2	EDC3	ENSPCOP00000020175	ENSPCOP00000005080	Ataxin 2.	Enhancer of mRNA decapping 3.	0.541
ATXN2	ENSPCOP00000009677	ENSPCOP00000020175	ENSPCOP00000009677	Ataxin 2.	TFG domain-containing protein.	0.470
ATXN2	LSM12	ENSPCOP00000020175	ENSPCOP00000030460	Ataxin 2.	LSM12 homolog.	0.991
ATXN2	LSM14B	ENSPCOP00000020175	ENSPCOP00000005445	Ataxin 2.	LSM family member 14B.	0.430
ATXN2	NAA38	ENSPCOP00000020175	ENSPCOP00000017984	Ataxin 2.	N(alpha)-acetyltransferase 38, NatC auxiliary subunit.	0.800
ATXN2	SNRPN	ENSPCOP00000020175	ENSPCOP00000006223	Ataxin 2.	Small nuclear ribonucleoprotein-associated protein.	0.928
ATXN2L	ATXN2	ENSPCOP00000025142	ENSPCOP00000020175	Ataxin 2 like.	Ataxin 2.	0.891
ATXN2L	EDC3	ENSPCOP00000025142	ENSPCOP00000005080	Ataxin 2 like.	Enhancer of mRNA decapping 3.	0.541
ATXN2L	ENSPCOP00000009677	ENSPCOP00000025142	ENSPCOP00000009677	Ataxin 2 like.	TFG domain-containing protein.	0.451
ATXN2L	LSM12	ENSPCOP00000025142	ENSPCOP00000030460	Ataxin 2 like.	LSM12 homolog.	0.991
ATXN2L	LSM14B	ENSPCOP00000025142	ENSPCOP00000005445	Ataxin 2 like.	LSM family member 14B.	0.430
ATXN2L	NAA38	ENSPCOP00000025142	ENSPCOP00000017984	Ataxin 2 like.	N(alpha)-acetyltransferase 38, NatC auxiliary subunit.	0.800
ATXN2L	SNRPN	ENSPCOP00000025142	ENSPCOP00000006223	Ataxin 2 like.	Small nuclear ribonucleoprotein-associated protein.	0.928
EDC3	ATXN2	ENSPCOP00000005080	ENSPCOP00000020175	Enhancer of mRNA decapping 3.	Ataxin 2.	0.541
EDC3	ATXN2L	ENSPCOP00000005080	ENSPCOP00000025142	Enhancer of mRNA decapping 3.	Ataxin 2 like.	0.541
EDC3	ENSPCOP00000009677	ENSPCOP00000005080	ENSPCOP00000009677	Enhancer of mRNA decapping 3.	TFG domain-containing protein.	0.885
EDC3	ENSPCOP00000025981	ENSPCOP00000005080	ENSPCOP00000025981	Enhancer of mRNA decapping 3.	Sm domain-containing protein.	0.728
EDC3	LSM1	ENSPCOP00000005080	ENSPCOP00000018076	Enhancer of mRNA decapping 3.	U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.	0.874
EDC3	LSM1-2	ENSPCOP00000005080	ENSPCOP00000022400	Enhancer of mRNA decapping 3.	U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.	0.874