STRINGSTRING
RFC3 RFC3 RFC5 RFC5 LOC105824103 LOC105824103 APEX1 APEX1 RCBTB2 RCBTB2 RPA3 RPA3 VWA5B1 VWA5B1 RCBTB1 RCBTB1 LIG1 LIG1 POLE3 POLE3 POLE2 POLE2 RFC2 RFC2 RFC1 RFC1 POLB POLB VWA5B2 VWA5B2 POLD3 POLD3 PARP2 PARP2 RPA1 RPA1 MEIOB MEIOB FEN1 FEN1 PARP3 PARP3 ENSPCOP00000007843 ENSPCOP00000007843 ADPRHL2 ADPRHL2 ENSPCOP00000008190 ENSPCOP00000008190 PCNA PCNA APEX2 APEX2 PARP1 PARP1 POLE4 POLE4 ATAD5 ATAD5 POLE POLE POLD4 POLD4 POLD2 POLD2 POLD1 POLD1 PARG PARG RFC4 RFC4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RFC3Replication factor C subunit 3. (356 aa)
RFC5AAA domain-containing protein. (338 aa)
LOC105824103Uncharacterized protein. (430 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (551 aa)
RPA3Replication protein A3. (107 aa)
VWA5B1Von Willebrand factor A domain containing 5B1. (1212 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
LIG1DNA ligase. (916 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (147 aa)
POLE2DNA polymerase epsilon 2, accessory subunit. (439 aa)
RFC2Replication factor C subunit 2. (352 aa)
RFC1Replication factor C subunit 1. (1113 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (333 aa)
VWA5B2Von Willebrand factor A domain containing 5B2. (1247 aa)
POLD3DNA polymerase delta 3, accessory subunit. (359 aa)
PARP2Poly [ADP-ribose] polymerase. (581 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
MEIOBMeiosis specific with OB-fold. (289 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
PARP3Poly [ADP-ribose] polymerase. (520 aa)
ENSPCOP00000007843Uncharacterized protein. (432 aa)
ADPRHL2ADP-ribosylhydrolase like 2. (365 aa)
ENSPCOP00000008190AAA domain-containing protein. (331 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
APEX2DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (518 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (118 aa)
ATAD5ATPase family AAA domain containing 5. (1646 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2284 aa)
POLD4Uncharacterized protein. (107 aa)
POLD2DNA polymerase delta 2, accessory subunit. (504 aa)
POLD1DNA polymerase. (1125 aa)
PARGPoly(ADP-ribose) glycohydrolase. (970 aa)
RFC4Replication factor C subunit 4. (365 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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