STRINGSTRING
ENSPCOP00000014538 ENSPCOP00000014538 DYNLL2 DYNLL2 TFDP1 TFDP1 E2F1 E2F1 AKT2 AKT2 BCL2L11 BCL2L11 YWHAH YWHAH MAPK8 MAPK8 AKT3 AKT3 AKT1 AKT1 YWHAQ YWHAQ YWHAZ YWHAZ YWHAB YWHAB BAD BAD TP63 TP63 TP53 TP53 BID BID BCL2 BCL2 MAPK10 MAPK10 TFDP2 TFDP2 YWHAE YWHAE PPP3R1 PPP3R1 SFN SFN PMAIP1 PMAIP1 PPP1R13B PPP1R13B YWHAG YWHAG DYNLL1 DYNLL1 BMF BMF PPP3CC PPP3CC TP73 TP73
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPCOP0000001453814_3_3 domain-containing protein; Belongs to the 14-3-3 family. (256 aa)
DYNLL2Dynein light chain. (89 aa)
TFDP1Transcription factor. (409 aa)
E2F1E2F transcription factor 1. (436 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
BCL2L11BCL2 like 11. (200 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
MAPK8Mitogen-activated protein kinase 8. (346 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
YWHAQTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta; Belongs to the 14-3-3 family. (249 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (256 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
BADBCL2 associated agonist of cell death. (168 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (220 aa)
BCL2BCL2 apoptosis regulator. (234 aa)
MAPK10Mitogen-activated protein kinase. (473 aa)
TFDP2Transcription factor. (405 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
PPP3R1Uncharacterized protein. (189 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
PMAIP1Uncharacterized protein. (54 aa)
PPP1R13BProtein phosphatase 1 regulatory subunit 13B. (1088 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa)
DYNLL1Dynein light chain. (89 aa)
BMFBcl2 modifying factor. (184 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (588 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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