STRINGSTRING
HGF HGF TLN2 TLN2 LHFPL1 LHFPL1 A2M A2M RARRES2 RARRES2 FAM49A FAM49A BTBD9 BTBD9 SERPING1 SERPING1 IGF1 IGF1 LHFPL6 LHFPL6 CDNF CDNF CFL1 CFL1 ENSPCOP00000020101 ENSPCOP00000020101 ORM1 ORM1 SERBP1 SERBP1 LRRIQ4 LRRIQ4 ENDOG ENDOG F8 F8 ENSPCOP00000021090 ENSPCOP00000021090 VEGFC VEGFC TRO TRO A2ML1 A2ML1 SRL SRL LRRC38 LRRC38 TGFB1 TGFB1 TUBA4A TUBA4A FGA FGA VEGFA VEGFA CYB5R1 CYB5R1 THBS1 THBS1 PDGFA PDGFA FN1 FN1 ENSPCOP00000024844 ENSPCOP00000024844 ENSPCOP00000024978 ENSPCOP00000024978 FAM49B FAM49B ALDOA ALDOA PROS1 PROS1 STXBP2 STXBP2 CD37 CD37 VWF VWF WDR1 WDR1 TLN1 TLN1 LOC105808462 LOC105808462 TLNRD1 TLNRD1 CSMD2 CSMD2 TF TF CLPB CLPB HSPA5 HSPA5 ENSPCOP00000026958 ENSPCOP00000026958 CDC37L1 CDC37L1 ITGA2B ITGA2B PLG PLG ACTN2 ACTN2 PLEK2 PLEK2 ACTN4 ACTN4 CLUL1 CLUL1 PCYOX1L PCYOX1L ECM1 ECM1 HRG HRG TIMP1 TIMP1 CALU CALU SZRD1 SZRD1 LOC105817025 LOC105817025 SPEGNB SPEGNB QSOX2 QSOX2 TAGLN TAGLN LOC105825493 LOC105825493 IGF2 IGF2 PPIA PPIA SERPINA4 SERPINA4 SRGN SRGN ITIH4 ITIH4 VEGFD VEGFD GTPBP1 GTPBP1 APP APP IGSF3 IGSF3 GZMK GZMK SERPINE1 SERPINE1 CD36 CD36 VTI1B VTI1B SYTL3 SYTL3 TENM3 TENM3 CPAMD8 CPAMD8 SYTL4 SYTL4 QSOX1 QSOX1 PCDH7 PCDH7 SCG3 SCG3 LOC105811829 LOC105811829 APLP2 APLP2 CTSW CTSW FRZB FRZB VEGFB VEGFB PHACTR4 PHACTR4 ACTN1 ACTN1 PCYOX1 PCYOX1 CD109 CD109 LOC105824409 LOC105824409 FGB FGB TEX264 TEX264 CLEC3B CLEC3B TGFB3 TGFB3 TENM4 TENM4 VCL VCL ABCC4 ABCC4 MILR1 MILR1 PHACTR3 PHACTR3 PLEK PLEK ENSPCOP00000004692 ENSPCOP00000004692 GTPBP2 GTPBP2 CFL2 CFL2 LOC105821997 LOC105821997 MAGED2 MAGED2 KNG1 KNG1 RAB27B RAB27B PHACTR1 PHACTR1 FLNA FLNA LAMP2 LAMP2 PSAP PSAP MANF MANF PDGFB PDGFB CAP1 CAP1 CHID1 CHID1 APOA1 APOA1 CLU CLU ANXA11 ANXA11 ENDOD1 ENDOD1 PECAM1 PECAM1 ENSPCOP00000002717 ENSPCOP00000002717 ENSPCOP00000002628 ENSPCOP00000002628 SELP SELP ANXA10 ANXA10 SPP2 SPP2 ANXA5 ANXA5 ENSPCOP00000002125 ENSPCOP00000002125 LOC105822640 LOC105822640 ENSPCOP00000000149 ENSPCOP00000000149 FERMT3 FERMT3 PHACTR2 PHACTR2 GAS6 GAS6 LYRM7 LYRM7 SERPINF2 SERPINF2 TENM2 TENM2 TGFB2 TGFB2 APOOL APOOL SYTL5 SYTL5 LHFPL2 LHFPL2 NHLRC2 NHLRC2 TENM1 TENM1 OLA1 OLA1 DSTN DSTN CSMD1 CSMD1 MMRN1 MMRN1 LRRC55 LRRC55 CD9 CD9 A1BG A1BG FGG FGG LOC105812050 LOC105812050 AHSG AHSG ANXA13 ANXA13 EGF EGF EXOG EXOG TMSB15A TMSB15A TIMP3 TIMP3 LOC105820755 LOC105820755 ANXA9 ANXA9 SCCPDH SCCPDH FAM3C FAM3C ANXA4 ANXA4 APLP1 APLP1 TSPAN18 TSPAN18 SPARC SPARC ANXA7 ANXA7 FETUB FETUB HABP4 HABP4 LOC105819216 LOC105819216 LGALS3BP LGALS3BP F13A1 F13A1 TAGLN3 TAGLN3 BRPF3 BRPF3 ITIH3 ITIH3 TMSB10 TMSB10 SFRP4 SFRP4 TAGLN2 TAGLN2 ALB ALB CFD CFD CD63 CD63 SERPINA1 SERPINA1 TMSB15B TMSB15B LY6G6F LY6G6F
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (703 aa)
TLN2Talin 2. (2542 aa)
LHFPL1LHFPL tetraspan subfamily member 1. (220 aa)
A2MAlpha-2-macroglobulin. (1420 aa)
RARRES2Retinoic acid receptor responder 2. (163 aa)
FAM49AFamily with sequence similarity 49 member A. (323 aa)
BTBD9BTB domain containing 9. (611 aa)
SERPING1Serpin family G member 1; Belongs to the serpin family. (491 aa)
IGF1Insulin like growth factor 1. (208 aa)
LHFPL6LHFPL tetraspan subfamily member 6. (200 aa)
CDNFCerebral dopamine neurotrophic factor. (112 aa)
CFL1ADF-H domain-containing protein. (178 aa)
ENSPCOP00000020101OBG-type G domain-containing protein. (367 aa)
ORM1Lipocln_cytosolic_FA-bd_dom domain-containing protein. (200 aa)
SERBP1SERPINE1 mRNA binding protein 1. (407 aa)
LRRIQ4Leucine rich repeats and IQ motif containing 4. (560 aa)
ENDOGEndonuclease. (300 aa)
F8Coagulation factor VIII; Belongs to the multicopper oxidase family. (2348 aa)
ENSPCOP00000021090Uncharacterized protein. (165 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (367 aa)
TROTrophinin. (1411 aa)
A2ML1Alpha-2-macroglobulin like 1. (1399 aa)
SRLSarcalumenin; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (473 aa)
LRRC38Leucine rich repeat containing 38. (295 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
TUBA4ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
FGAFib_alpha domain-containing protein. (649 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
CYB5R1NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (305 aa)
THBS1Thrombospondin 1. (1185 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
FN1Fibronectin 1. (2290 aa)
ENSPCOP00000024844Uncharacterized protein. (639 aa)
ENSPCOP00000024978ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (148 aa)
FAM49BFamily with sequence similarity 49 member B. (324 aa)
ALDOAFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (418 aa)
PROS1Protein S. (675 aa)
STXBP2Syntaxin binding protein 2; Belongs to the STXBP/unc-18/SEC1 family. (593 aa)
CD37Tetraspanin. (275 aa)
VWFVon Willebrand factor. (2807 aa)
WDR1WD repeat domain 1. (606 aa)
TLN1Talin 1. (2548 aa)
LOC105808462Thymosin beta-4. (50 aa)
TLNRD1Talin rod domain containing 1. (364 aa)
CSMD2CUB and Sushi multiple domains 2. (3597 aa)
TFTransferrin; Belongs to the transferrin family. (697 aa)
CLPBClpB homolog, mitochondrial AAA ATPase chaperonin. (707 aa)
HSPA5Uncharacterized protein; Belongs to the heat shock protein 70 family. (654 aa)
ENSPCOP00000026958Uncharacterized protein. (5601 aa)
CDC37L1Cell division cycle 37 like 1. (337 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1039 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (772 aa)
ACTN2Actinin alpha 2. (874 aa)
PLEK2Pleckstrin 2. (353 aa)
ACTN4Actinin alpha 4. (943 aa)
CLUL1Clusterin; Belongs to the clusterin family. (473 aa)
PCYOX1LPrenylcysteine oxidase 1 like. (494 aa)
ECM1Extracellular matrix protein 1. (570 aa)
HRGHistidine rich glycoprotein. (468 aa)
TIMP1TIMP metallopeptidase inhibitor 1. (207 aa)
CALUCalumenin. (323 aa)
SZRD1SUZ RNA binding domain containing 1. (152 aa)
LOC105817025ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (218 aa)
SPEGNBSPEG neighbor. (214 aa)
QSOX2Sulfhydryl oxidase. (663 aa)
TAGLNTransgelin; Belongs to the calponin family. (201 aa)
LOC105825493Annexin. (337 aa)
IGF2Insulin like growth factor 2. (236 aa)
PPIAPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (164 aa)
SERPINA4Serpin family A member 4; Belongs to the serpin family. (427 aa)
SRGNSerglycin. (153 aa)
ITIH4Inter-alpha-trypsin inhibitor heavy chain 4. (901 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (319 aa)
GTPBP1GTP binding protein 1. (677 aa)
APPAmyloid beta precursor protein. (772 aa)
IGSF3Immunoglobulin superfamily member 3. (1214 aa)
GZMKGranzyme K; Belongs to the peptidase S1 family. (268 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
VTI1BVesicle transport through interaction with t-SNAREs 1B. (232 aa)
SYTL3Synaptotagmin like 3. (610 aa)
TENM3Teneurin transmembrane protein 3. (2583 aa)
CPAMD8C3 and PZP like alpha-2-macroglobulin domain containing 8. (1926 aa)
SYTL4Synaptotagmin like 4. (674 aa)
QSOX1Sulfhydryl oxidase. (711 aa)
PCDH7Protocadherin 7. (1069 aa)
SCG3Secretogranin III. (340 aa)
LOC105811829Uncharacterized protein; Belongs to the heat shock protein 70 family. (649 aa)
APLP2Amyloid beta precursor like protein 2. (757 aa)
CTSWCathepsin W; Belongs to the peptidase C1 family. (374 aa)
FRZBFrizzled related protein. (325 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (188 aa)
PHACTR4Phosphatase and actin regulator. (702 aa)
ACTN1Actinin alpha 1. (924 aa)
PCYOX1Prenylcys_lyase domain-containing protein. (485 aa)
CD109CD109 molecule. (1359 aa)
LOC105824409Uncharacterized protein. (98 aa)
FGBFibrinogen beta chain. (492 aa)
TEX264Testis expressed 264, ER-phagy receptor. (313 aa)
CLEC3BC-type lectin domain family 3 member B. (202 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
TENM4Teneurin transmembrane protein 4. (2769 aa)
VCLVinculin. (1134 aa)
ABCC4ATP binding cassette subfamily C member 4. (1324 aa)
MILR1Mast cell immunoglobulin like receptor 1. (339 aa)
PHACTR3Phosphatase and actin regulator. (507 aa)
PLEKPleckstrin. (350 aa)
ENSPCOP00000004692Uncharacterized protein. (103 aa)
GTPBP2GTP binding protein 2. (602 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
LOC105821997Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (50 aa)
MAGED2MAGE family member D2. (602 aa)
KNG1Uncharacterized protein. (391 aa)
RAB27BRAB27B, member RAS oncogene family. (218 aa)
PHACTR1Phosphatase and actin regulator. (580 aa)
FLNAFilamin A. (2647 aa)
LAMP2Lysosomal associated membrane protein 2. (414 aa)
PSAPProsaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. (523 aa)
MANFMesencephalic astrocyte derived neurotrophic factor. (255 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
CAP1Adenylyl cyclase-associated protein; Belongs to the CAP family. (474 aa)
CHID1Chitinase domain containing 1; Belongs to the glycosyl hydrolase 18 family. (393 aa)
APOA1Apolipoprotein A1. (265 aa)
CLUClusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (450 aa)
ANXA11Annexin. (504 aa)
ENDOD1Endonuclease domain containing 1. (500 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (698 aa)
ENSPCOP00000002717Thioredoxin domain-containing protein. (148 aa)
ENSPCOP00000002628Uncharacterized protein. (43 aa)
SELPSelectin P. (768 aa)
ANXA10Annexin A10. (324 aa)
SPP2Secreted phosphoprotein 2. (211 aa)
ANXA5Annexin. (321 aa)
ENSPCOP00000002125ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (149 aa)
LOC105822640Integrin beta; Belongs to the integrin beta chain family. (454 aa)
ENSPCOP00000000149Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (50 aa)
FERMT3Fermitin family member 3. (662 aa)
PHACTR2Phosphatase and actin regulator. (587 aa)
GAS6Growth arrest specific 6. (648 aa)
LYRM7Uncharacterized protein. (44 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (487 aa)
TENM2Teneurin transmembrane protein 2. (2774 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
APOOLMICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (230 aa)
SYTL5Synaptotagmin like 5. (754 aa)
LHFPL2LHFPL tetraspan subfamily member 2. (230 aa)
NHLRC2NHL repeat containing 2. (707 aa)
TENM1Teneurin transmembrane protein 1. (2732 aa)
OLA1Obg-like ATPase 1; Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP. (407 aa)
DSTNDestrin, actin depolymerizing factor; Belongs to the actin-binding proteins ADF family. (170 aa)
CSMD1CUB and Sushi multiple domains 1. (3147 aa)
MMRN1Multimerin 1. (1222 aa)
LRRC55Leucine rich repeat containing 55. (311 aa)
CD9Tetraspanin. (228 aa)
A1BGAlpha-1-B glycoprotein. (519 aa)
FGGFibrinogen gamma chain. (456 aa)
LOC105812050Prenylcys_lyase domain-containing protein. (408 aa)
AHSGAlpha 2-HS glycoprotein. (364 aa)
ANXA13Annexin. (357 aa)
EGFEpidermal growth factor. (1132 aa)
EXOGExo/endonuclease G. (368 aa)
TMSB15AThymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (45 aa)
TIMP3TIMP metallopeptidase inhibitor 3. (211 aa)
LOC105820755Uncharacterized protein. (581 aa)
ANXA9Annexin. (284 aa)
SCCPDHSaccharopine dehydrogenase (putative). (391 aa)
FAM3CFamily with sequence similarity 3 member C. (227 aa)
ANXA4Annexin. (270 aa)
APLP1Amyloid beta precursor like protein 1. (653 aa)
TSPAN18Tetraspanin. (248 aa)
SPARCSecreted protein acidic and cysteine rich. (303 aa)
ANXA7Annexin. (446 aa)
FETUBFetuin B. (384 aa)
HABP4Hyaluronan binding protein 4. (417 aa)
LOC105819216YchF-GTPase_C domain-containing protein. (229 aa)
LGALS3BPUncharacterized protein. (581 aa)
F13A1Coagulation factor XIII A chain. (732 aa)
TAGLN3Transgelin; Belongs to the calponin family. (199 aa)
BRPF3Bromodomain and PHD finger containing 3. (1205 aa)
ITIH3Inter-alpha-trypsin inhibitor heavy chain 3. (888 aa)
TMSB10Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (44 aa)
SFRP4Secreted frizzled related protein 4. (342 aa)
TAGLN2Transgelin; Belongs to the calponin family. (220 aa)
ALBAlbumin. (494 aa)
CFDComplement factor D; Belongs to the peptidase S1 family. (258 aa)
CD63Tetraspanin. (237 aa)
SERPINA1Serpin family A member 1; Belongs to the serpin family. (357 aa)
TMSB15BUncharacterized protein. (46 aa)
LY6G6FIg-like domain-containing protein. (296 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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