STRINGSTRING
LOC105816759 LOC105816759 ERBB3 ERBB3 ERBB2 ERBB2 USP8 USP8 AKT3 AKT3 AKT1 AKT1 ENSPCOP00000029403 ENSPCOP00000029403 PRKCA PRKCA HSP90AA1 HSP90AA1 SHC1 SHC1 UBA52 UBA52 LOC105820322 LOC105820322 ENSPCOP00000002686 ENSPCOP00000002686 RNF41 RNF41 ENSPCOP00000000722 ENSPCOP00000000722 STUB1 STUB1 HBEGF HBEGF NRAS NRAS NRG4 NRG4 GRB7 GRB7 FYN FYN NRG1 NRG1 CDC37 CDC37 SOS1 SOS1 ENSPCOP00000009588 ENSPCOP00000009588 KRAS KRAS FNDC3A FNDC3A PTPN18 PTPN18 ERBIN ERBIN CSDE1 CSDE1 ENSPCOP00000012718 ENSPCOP00000012718 MATK MATK MEMO1 MEMO1 EGF EGF PIK3CA PIK3CA RPS27A RPS27A GRB2 GRB2 LOC105812452 LOC105812452 EGFR EGFR PIK3R1 PIK3R1 ENSPCOP00000018566 ENSPCOP00000018566 SRC SRC ENSPCOP00000018904 ENSPCOP00000018904 AKT2 AKT2 BTC BTC HRAS HRAS FNDC3B FNDC3B NRG3 NRG3 PTPN12 PTPN12 NRG2 NRG2 EREG EREG ENSPCOP00000023542 ENSPCOP00000023542 PLCG1 PLCG1 CUL5 CUL5 PRKCE PRKCE PRKCD PRKCD ENSPCOP00000026845 ENSPCOP00000026845
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC105816759Ubiquitin-like domain-containing protein. (156 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1337 aa)
ERBB2Receptor protein-tyrosine kinase. (1252 aa)
USP8Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1068 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ENSPCOP00000029403Protein kinase domain-containing protein. (429 aa)
PRKCAUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (575 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (816 aa)
SHC1SHC adaptor protein 1. (582 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
LOC105820322Ubiquitin-like domain-containing protein. (77 aa)
ENSPCOP00000002686CSD_1 domain-containing protein. (293 aa)
RNF41Ring finger protein 41. (317 aa)
ENSPCOP00000000722Protein kinase domain-containing protein. (67 aa)
STUB1STIP1 homology and U-box containing protein 1. (304 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
NRG4Neuregulin 4. (116 aa)
GRB7Growth factor receptor bound protein 7. (531 aa)
FYNTyrosine-protein kinase. (537 aa)
NRG1Neuregulin 1. (710 aa)
CDC37Cell division cycle 37. (376 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
ENSPCOP00000009588Uncharacterized protein. (316 aa)
KRASUncharacterized protein. (75 aa)
FNDC3AFibronectin type III domain containing 3A. (1044 aa)
PTPN18Protein tyrosine phosphatase non-receptor type 18. (336 aa)
ERBINErbb2 interacting protein. (1377 aa)
CSDE1Cold shock domain containing E1. (798 aa)
ENSPCOP00000012718Ubiquitin-like domain-containing protein. (74 aa)
MATKTyrosine-protein kinase. (507 aa)
MEMO1Mediator of cell motility 1. (297 aa)
EGFEpidermal growth factor. (1132 aa)
PIK3CAPhosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
RPS27ARibosomal protein S27a. (156 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
LOC105812452HATPase_c domain-containing protein. (680 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
ENSPCOP00000018566Uncharacterized protein. (113 aa)
SRCTyrosine-protein kinase. (543 aa)
ENSPCOP00000018904Ubiquitin-like domain-containing protein. (131 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
BTCBetacellulin. (140 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
FNDC3BFibronectin type III domain containing 3B. (1156 aa)
NRG3Neuregulin 3. (721 aa)
PTPN12Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. (705 aa)
NRG2Neuregulin 2. (850 aa)
EREGEpiregulin. (166 aa)
ENSPCOP00000023542Ubiquitin-like domain-containing protein. (112 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1304 aa)
CUL5Cullin 5; Belongs to the cullin family. (685 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
ENSPCOP00000026845USP8_dimer domain-containing protein. (167 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.