STRINGSTRING
ITPR2 ITPR2 GNB3 GNB3 GCGR GCGR ENSPCOP00000031946 ENSPCOP00000031946 CACNA1E CACNA1E PRKAR2A PRKAR2A GNAS GNAS GNG7 GNG7 CACNA2D2 CACNA2D2 PKLR PKLR ACACB ACACB PLCB3 PLCB3 GNAI2 GNAI2 ADCY5 ADCY5 PRKCA PRKCA PRKACA PRKACA FAP FAP CACNB3 CACNB3 MLXIPL MLXIPL PRKAG2 PRKAG2 PRKAA2 PRKAA2 ENSPCOP00000026249 ENSPCOP00000026249 SYT5 SYT5 PRKAR2B PRKAR2B AHCYL1 AHCYL1 ACLY ACLY PPP2CA PPP2CA CACNA1F CACNA1F ITPR1 ITPR1 KCNB1 KCNB1 GNAQ GNAQ ACSL4 ACSL4 GNA11 GNA11 ADCY9 ADCY9 GNA14 GNA14 ADCY7 ADCY7 RAPGEF5 RAPGEF5 GNG2 GNG2 ENSPCOP00000023702 ENSPCOP00000023702 GNG13 GNG13 AGPAT1 AGPAT1 RAPGEFL1 RAPGEFL1 TKTL1 TKTL1 GNB4 GNB4 GLP1R GLP1R GNG11 GNG11 ACSL3 ACSL3 PPP2R1B PPP2R1B RAPGEF4 RAPGEF4 PRKAR1B PRKAR1B ADRA2C ADRA2C GNB1 GNB1 MLXIP MLXIP ITPR3 ITPR3 PPP2R5D PPP2R5D CNBD2 CNBD2 CACNB2 CACNB2 CACNA1C CACNA1C ADCY3 ADCY3 PFKFB1 PFKFB1 LOC105823863 LOC105823863 ADIPOR1 ADIPOR1 GNB5 GNB5 ACACA ACACA THAP7 THAP7 PLCB2 PLCB2 ENSPCOP00000013862 ENSPCOP00000013862 ABCC8 ABCC8 TALDO1 TALDO1 ADIPOQ ADIPOQ CACNA1D CACNA1D GNG3 GNG3 CACNA1A CACNA1A ADCY8 ADCY8 ADCY4 ADCY4 ADCY1 ADCY1 KCNG2 KCNG2 INS INS CD36 CD36 FASN FASN GCG GCG ADIPOR2 ADIPOR2 ENSPCOP00000009588 ENSPCOP00000009588 ENSPCOP00000008641 ENSPCOP00000008641 KCNC2 KCNC2 MLX MLX SLC2A2 SLC2A2 PRKAB2 PRKAB2 PPP2CB PPP2CB PRKACB PRKACB GNG8 GNG8 RAPGEF3 RAPGEF3 GNA15 GNA15 PLCB1 PLCB1 GNB2 GNB2 CACNA2D1 CACNA2D1 GNG10 GNG10 STXBP1 STXBP1 GNGT2 GNGT2 TKTL2 TKTL2 VAMP2 VAMP2 STK11 STK11 PPP2R1A PPP2R1A MARCKS MARCKS KCNS3 KCNS3 KCNJ11 KCNJ11 ENSPCOP00000002561 ENSPCOP00000002561 ADCY6 ADCY6 RAP1A RAP1A SLC2A1 SLC2A1 IQGAP1 IQGAP1 ADCY2 ADCY2 TKT TKT GNG4 GNG4 GNG12 GNG12 PRKAR1A PRKAR1A SNAP25 SNAP25
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2702 aa)
GNB3G protein subunit beta 3. (340 aa)
GCGRGlucagon receptor; Belongs to the G-protein coupled receptor 2 family. (485 aa)
ENSPCOP00000031946G protein gamma domain-containing protein. (68 aa)
CACNA1EVoltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2293 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (399 aa)
GNASUncharacterized protein. (394 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CACNA2D2Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1153 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (574 aa)
ACACBAcetyl-CoA carboxylase beta. (2172 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1233 aa)
GNAI2G protein subunit alpha i2. (355 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1258 aa)
PRKCAUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (575 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
FAPFibroblast activation protein alpha; Belongs to the peptidase S9B family. (760 aa)
CACNB3Calcium voltage-gated channel auxiliary subunit beta 3. (484 aa)
MLXIPLMLX interacting protein like. (856 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (540 aa)
PRKAA2Non-specific serine/threonine protein kinase. (553 aa)
ENSPCOP00000026249Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (79 aa)
SYT5Synaptotagmin 5. (386 aa)
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (418 aa)
AHCYL1Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family. (530 aa)
ACLYATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1110 aa)
PPP2CASerine/threonine-protein phosphatase. (295 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1973 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2732 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
GNAQG protein subunit alpha q. (359 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (711 aa)
GNA11G protein subunit alpha 11. (313 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
GNA14G protein subunit alpha 14. (355 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
RAPGEF5Rap guanine nucleotide exchange factor 5. (730 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (109 aa)
ENSPCOP00000023702Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (61 aa)
GNG13G protein subunit gamma 13. (67 aa)
AGPAT11-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (287 aa)
RAPGEFL1Rap guanine nucleotide exchange factor like 1. (662 aa)
TKTL1Transketolase like 1. (540 aa)
GNB4G protein subunit beta 4. (321 aa)
GLP1RGlucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (451 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (673 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (552 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (1011 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (381 aa)
ADRA2CAdrenoceptor alpha 2C; Belongs to the G-protein coupled receptor 1 family. (351 aa)
GNB1G protein subunit beta 1. (334 aa)
MLXIPMLX interacting protein. (925 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2664 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (598 aa)
CNBD2Cyclic nucleotide binding domain containing 2. (583 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (660 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2016 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1. (471 aa)
LOC105823863Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ADIPOR1Adiponectin receptor 1. (375 aa)
GNB5G protein subunit beta 5. (395 aa)
ACACAAcetyl-CoA carboxylase alpha. (2347 aa)
THAP7THAP domain containing 7. (309 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
ENSPCOP00000013862SER_THR_PHOSPHATASE domain-containing protein. (209 aa)
ABCC8ATP binding cassette subfamily C member 8. (1582 aa)
TALDO1Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (337 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2180 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2494 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1229 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
KCNG2Potassium voltage-gated channel modifier subfamily G member 2; Belongs to the potassium channel family. (428 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
FASNFatty acid synthase. (2506 aa)
GCGGlucagon. (180 aa)
ADIPOR2Adiponectin receptor 2. (325 aa)
ENSPCOP00000009588Uncharacterized protein. (316 aa)
ENSPCOP00000008641Uncharacterized protein. (715 aa)
KCNC2Potassium voltage-gated channel subfamily C member 2; Belongs to the potassium channel family. (638 aa)
MLXMAX dimerization protein MLX. (244 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (399 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (923 aa)
GNA15G protein subunit alpha 15. (374 aa)
PLCB1Phosphoinositide phospholipase C. (1010 aa)
GNB2G protein subunit beta 2. (340 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (740 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
STXBP1Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (604 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (88 aa)
TKTL2Transketolase like 2. (607 aa)
VAMP2V-SNARE coiled-coil homology domain-containing protein. (118 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (442 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
MARCKSMyristoylated alanine rich protein kinase C substrate. (334 aa)
KCNS3Potassium voltage-gated channel modifier subfamily S member 3; Belongs to the potassium channel family. (490 aa)
KCNJ11Potassium voltage-gated channel subfamily J member 11. (390 aa)
ENSPCOP00000002561Uncharacterized protein. (546 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1167 aa)
RAP1ARAP1A, member of RAS oncogene family. (165 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (495 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1400 aa)
ADCY2Adenylate cyclase 2. (904 aa)
TKTTransketolase. (623 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (381 aa)
SNAP25Synaptosomal-associated protein; Belongs to the SNAP-25 family. (206 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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