STRINGSTRING
BTRC BTRC MAPK14 MAPK14 LRRC45 LRRC45 ENSPCOP00000017161 ENSPCOP00000017161 TBK1 TBK1 RPS27A RPS27A PPP4R1 PPP4R1 MAP2K1 MAP2K1 MAPK7 MAPK7 TNIP2 TNIP2 TRAF2 TRAF2 MAPK11 MAPK11 NFKBIA NFKBIA ENSPCOP00000013862 ENSPCOP00000013862 S100B S100B RPS6KA1 RPS6KA1 ATF7 ATF7 NLRC5 NLRC5 ENSPCOP00000012718 ENSPCOP00000012718 TAB3 TAB3 FOSL2 FOSL2 TP53 TP53 ENSPCOP00000031725 ENSPCOP00000031725 MAP2K3 MAP2K3 MAP2K4 MAP2K4 ENSPCOP00000031440 ENSPCOP00000031440 NOD1 NOD1 RIPK3 RIPK3 MAPK1 MAPK1 CHUK CHUK NLRP6 NLRP6 IRAK1 IRAK1 NOD2 NOD2 MAP3K20 MAP3K20 LOC105823889 LOC105823889 MAPK8 MAPK8 IKBKE IKBKE DUSP7 DUSP7 LOC105816759 LOC105816759 N4BP1 N4BP1 IKBKG IKBKG CUL1 CUL1 ENSPCOP00000026416 ENSPCOP00000026416 USP14 USP14 TICAM1 TICAM1 ATF2 ATF2 ATF1 ATF1 LOC105824228 LOC105824228 LOC105820073 LOC105820073 MAPKAPK3 MAPKAPK3 MAP2K6 MAP2K6 PPP2CA PPP2CA ENSPCOP00000025404 ENSPCOP00000025404 CCDC71L CCDC71L ALPK1 ALPK1 APP APP SKP1 SKP1 FBXW11 FBXW11 NLRX1 NLRX1 IRF7 IRF7 UBE2D1 UBE2D1 NFKBIB NFKBIB NKIRAS2 NKIRAS2 HMGB1 HMGB1 S100A12 S100A12 RELCH RELCH FNBP4 FNBP4 LRRC14 LRRC14 LOC105819868 LOC105819868 TLR3 TLR3 MEF2C MEF2C LRRC31 LRRC31 MAPK3 MAPK3 NFKB1 NFKB1 TRAF3 TRAF3 DUSP4 DUSP4 ENSPCOP00000006977 ENSPCOP00000006977 LOC105818311 LOC105818311 VWC2 VWC2 PPP2CB PPP2CB LRRC34 LRRC34 KHNYN KHNYN VRK3 VRK3 MAPKAPK2 MAPKAPK2 MAP3K7 MAP3K7 LRRC74B LRRC74B IRF3 IRF3 SARM1 SARM1 CASP8 CASP8 LOC105818450 LOC105818450 ENSPCOP00000023542 ENSPCOP00000023542 TANK TANK CREB5 CREB5 ENSPCOP00000022199 ENSPCOP00000022199 TAB2 TAB2 MAPK10 MAPK10 RELA RELA FADD FADD BIRC2 BIRC2 LRRC71 LRRC71 IKBKB IKBKB MEF2A MEF2A TAB1 TAB1 PPP2R1B PPP2R1B ENSPCOP00000019479 ENSPCOP00000019479 ENSPCOP00000019388 ENSPCOP00000019388 IRAK2 IRAK2 LOC105814628 LOC105814628 UBA52 UBA52 ENSPCOP00000018904 ENSPCOP00000018904 TONSL TONSL RPS6KA5 RPS6KA5 PPP2R1A PPP2R1A NKIRAS1 NKIRAS1 ENSPCOP00000003656 ENSPCOP00000003656 LOC105820322 LOC105820322 BIRC3 BIRC3 LOC105818310 LOC105818310 MAP2K7 MAP2K7 ENSPCOP00000002718 ENSPCOP00000002718 ENSPCOP00000002561 ENSPCOP00000002561 LOC105809196 LOC105809196 MAPK9 MAPK9 LRRC74A LRRC74A DUSP6 DUSP6 ELK1 ELK1 TRAF6 TRAF6 AGER AGER PPP4R4 PPP4R4 FOS FOS CREB1 CREB1 RIPK1 RIPK1 RIPK2 RIPK2 NFKB2 NFKB2 PPP2R5D PPP2R5D DUSP3 DUSP3 RPS6KA2 RPS6KA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (609 aa)
MAPK14Mitogen-activated protein kinase 14. (340 aa)
LRRC45Leucine rich repeat containing 45. (655 aa)
ENSPCOP00000017161Mitogen-activated protein kinase kinase kinase 8. (119 aa)
TBK1TANK binding kinase 1. (690 aa)
RPS27ARibosomal protein S27a. (156 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (906 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (377 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (802 aa)
TNIP2TNFAIP3 interacting protein 2. (432 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
MAPK11Mitogen-activated protein kinase. (443 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
ENSPCOP00000013862SER_THR_PHOSPHATASE domain-containing protein. (209 aa)
S100BProtein S100; Belongs to the S-100 family. (92 aa)
RPS6KA1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (745 aa)
ATF7Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (483 aa)
NLRC5NLR family CARD domain containing 5. (1812 aa)
ENSPCOP00000012718Ubiquitin-like domain-containing protein. (74 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (710 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (326 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
ENSPCOP00000031725Protein kinase domain-containing protein. (272 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
MAP2K4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (410 aa)
ENSPCOP00000031440annotation not available (119 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (949 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (516 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (682 aa)
NLRP6NLR family pyrin domain containing 6. (890 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (713 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20. (800 aa)
LOC105823889Uncharacterized protein. (214 aa)
MAPK8Mitogen-activated protein kinase 8. (346 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (420 aa)
LOC105816759Ubiquitin-like domain-containing protein. (156 aa)
N4BP1NEDD4 binding protein 1. (896 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (490 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
ENSPCOP00000026416UBIQUITIN_CONJUGAT_2 domain-containing protein. (158 aa)
USP14Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (492 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (692 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ATF1Activating transcription factor 1. (270 aa)
LOC105824228UBIQUITIN_CONJUGAT_2 domain-containing protein. (147 aa)
LOC105820073WRNPLPNID domain-containing protein. (958 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (384 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (345 aa)
PPP2CASerine/threonine-protein phosphatase. (295 aa)
ENSPCOP00000025404Uncharacterized protein. (202 aa)
CCDC71LUncharacterized protein. (274 aa)
ALPK1Alpha kinase 1. (1234 aa)
APPAmyloid beta precursor protein. (772 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (138 aa)
FBXW11F-box and WD repeat domain containing 11. (542 aa)
NLRX1NLR family member X1. (975 aa)
IRF7Interferon regulatory factor 7. (383 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
NFKBIBNFKB inhibitor beta. (346 aa)
NKIRAS2NFKB inhibitor interacting Ras like 2. (220 aa)
HMGB1Uncharacterized protein. (187 aa)
S100A12Protein S100; Belongs to the S-100 family. (92 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1217 aa)
FNBP4Formin binding protein 4. (870 aa)
LRRC14Leucine rich repeat containing 14. (493 aa)
LOC105819868Protein kinase domain-containing protein. (302 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
LRRC31Leucine rich repeat containing 31. (496 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
NFKB1Nuclear factor kappa B subunit 1. (961 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (564 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
ENSPCOP00000006977IRF-3 domain-containing protein. (275 aa)
LOC105818311Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (120 aa)
VWC2Von Willebrand factor C domain containing 2. (325 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
LRRC34Uncharacterized protein. (211 aa)
KHNYNKH and NYN domain containing. (666 aa)
VRK3VRK serine/threonine kinase 3. (453 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (400 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (553 aa)
LRRC74BLeucine rich repeat containing 74B. (397 aa)
IRF3IRF tryptophan pentad repeat domain-containing protein. (419 aa)
SARM1Sterile alpha and TIR motif containing 1. (724 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (395 aa)
LOC105818450Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (122 aa)
ENSPCOP00000023542Ubiquitin-like domain-containing protein. (112 aa)
TANKTRAF family member associated NFKB activator. (425 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
ENSPCOP00000022199Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (282 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
MAPK10Mitogen-activated protein kinase. (473 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (205 aa)
BIRC2Baculoviral IAP repeat containing 2. (619 aa)
LRRC71Leucine rich repeat containing 71. (557 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (747 aa)
MEF2AMyocyte enhancer factor 2A. (495 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (552 aa)
ENSPCOP00000019479UBIQUITIN_CONJUGAT_2 domain-containing protein. (60 aa)
ENSPCOP00000019388UBIQUITIN_CONJUGAT_2 domain-containing protein. (151 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (532 aa)
LOC105814628HMG box domain-containing protein. (187 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
ENSPCOP00000018904Ubiquitin-like domain-containing protein. (131 aa)
TONSLTonsoku like, DNA repair protein. (1381 aa)
RPS6KA5Ribosomal protein S6 kinase A5. (643 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
NKIRAS1NFKB inhibitor interacting Ras like 1. (192 aa)
ENSPCOP00000003656Uncharacterized protein. (213 aa)
LOC105820322Ubiquitin-like domain-containing protein. (77 aa)
BIRC3Baculoviral IAP repeat containing 3. (597 aa)
LOC105818310Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (120 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
ENSPCOP00000002718Uncharacterized protein. (210 aa)
ENSPCOP00000002561Uncharacterized protein. (546 aa)
LOC105809196UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (89 aa)
MAPK9Mitogen-activated protein kinase 9. (417 aa)
LRRC74ALeucine rich repeat containing 74A. (488 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
ELK1ETS transcription factor ELK1. (430 aa)
TRAF6TNF receptor-associated factor. (498 aa)
AGERAdvanced glycosylation end-product specific receptor. (403 aa)
PPP4R4Protein phosphatase 4 regulatory subunit 4. (826 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (381 aa)
CREB1cAMP responsive element binding protein 1. (280 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (643 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (539 aa)
NFKB2Nuclear factor kappa B subunit 2. (895 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (598 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
RPS6KA2Ribosomal protein S6 kinase. (722 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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