32 items (Propithecus coquereli) - STRING interaction network

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Your Input:
	ENSPCOP00000002776	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (330 aa)
	TINF2	TERF1 interacting nuclear factor 2. (451 aa)
	SHQ1	SHQ1, H/ACA ribonucleoprotein assembly factor. (584 aa)
	POT1	Protection of telomeres 1. (600 aa)
	ENSPCOP00000004829	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (71 aa)
	RTEL1	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1286 aa)
	CCNA2	Cyclin A2; Belongs to the cyclin family. (432 aa)
	PIF1	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (643 aa)
	RUVBL1	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (245 aa)
	NHP2	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (153 aa)
	ANKRD66	Ankyrin repeat domain 66. (238 aa)
	TERF2	Telomeric repeat binding factor 2. (542 aa)
	TERF1	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (435 aa)
	CDK3	Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (304 aa)
	RBPMS2	RNA binding protein, mRNA processing factor 2. (208 aa)
	TRUB1	TruB pseudouridine synthase family member 1. (330 aa)
	ENSPCOP00000025432	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (747 aa)
	CCNA1	Cyclin A1; Belongs to the cyclin family. (442 aa)
	PPP6C	Serine/threonine-protein phosphatase. (305 aa)
	NOP10	NOP10 ribonucleoprotein. (64 aa)
	TERF2IP	TERF2 interacting protein. (393 aa)
	DKC1	Dyskerin pseudouridine synthase 1. (514 aa)
	RUVBL2	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (397 aa)
	GAR1	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (196 aa)
	WRAP53	WD repeat containing antisense to TP53. (540 aa)
	PPP6R2	Protein phosphatase 6 regulatory subunit 2. (931 aa)
	ACD	ACD shelterin complex subunit and telomerase recruitment factor. (513 aa)
	ANKRD44	Ankyrin repeat domain 44. (910 aa)
	CDK2	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
	ANKRD28	Ankyrin repeat domain 28. (1083 aa)
	PPP6R3	Protein phosphatase 6 regulatory subunit 3. (879 aa)
	LOC105807749	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (284 aa)

Your Current Organism:

Propithecus coquereli

NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACD	DKC1	ENSPCOP00000030285	ENSPCOP00000028469	ACD shelterin complex subunit and telomerase recruitment factor.	Dyskerin pseudouridine synthase 1.	0.808
ACD	ENSPCOP00000002776	ENSPCOP00000030285	ENSPCOP00000002776	ACD shelterin complex subunit and telomerase recruitment factor.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...]	0.963
ACD	ENSPCOP00000025432	ENSPCOP00000030285	ENSPCOP00000025432	ACD shelterin complex subunit and telomerase recruitment factor.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...]	0.963
ACD	GAR1	ENSPCOP00000030285	ENSPCOP00000028759	ACD shelterin complex subunit and telomerase recruitment factor.	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.	0.797
ACD	NHP2	ENSPCOP00000030285	ENSPCOP00000017747	ACD shelterin complex subunit and telomerase recruitment factor.	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family.	0.806
ACD	NOP10	ENSPCOP00000030285	ENSPCOP00000026468	ACD shelterin complex subunit and telomerase recruitment factor.	NOP10 ribonucleoprotein.	0.808
ACD	POT1	ENSPCOP00000030285	ENSPCOP00000004523	ACD shelterin complex subunit and telomerase recruitment factor.	Protection of telomeres 1.	0.998
ACD	RTEL1	ENSPCOP00000030285	ENSPCOP00000005128	ACD shelterin complex subunit and telomerase recruitment factor.	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	0.671
ACD	TERF1	ENSPCOP00000030285	ENSPCOP00000020972	ACD shelterin complex subunit and telomerase recruitment factor.	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.	0.991
ACD	TERF2	ENSPCOP00000030285	ENSPCOP00000020164	ACD shelterin complex subunit and telomerase recruitment factor.	Telomeric repeat binding factor 2.	0.992
ACD	TERF2IP	ENSPCOP00000030285	ENSPCOP00000027585	ACD shelterin complex subunit and telomerase recruitment factor.	TERF2 interacting protein.	0.992
ACD	TINF2	ENSPCOP00000030285	ENSPCOP00000000492	ACD shelterin complex subunit and telomerase recruitment factor.	TERF1 interacting nuclear factor 2.	0.998
ACD	TRUB1	ENSPCOP00000030285	ENSPCOP00000024330	ACD shelterin complex subunit and telomerase recruitment factor.	TruB pseudouridine synthase family member 1.	0.638
ACD	WRAP53	ENSPCOP00000030285	ENSPCOP00000029287	ACD shelterin complex subunit and telomerase recruitment factor.	WD repeat containing antisense to TP53.	0.782
ANKRD28	ANKRD44	ENSPCOP00000031380	ENSPCOP00000030744	Ankyrin repeat domain 28.	Ankyrin repeat domain 44.	0.879
ANKRD28	CDK2	ENSPCOP00000031380	ENSPCOP00000031182	Ankyrin repeat domain 28.	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	0.423
ANKRD28	CDK3	ENSPCOP00000031380	ENSPCOP00000022491	Ankyrin repeat domain 28.	Cyclin dependent kinase 3; Belongs to the protein kinase superfamily.	0.423
ANKRD28	DKC1	ENSPCOP00000031380	ENSPCOP00000028469	Ankyrin repeat domain 28.	Dyskerin pseudouridine synthase 1.	0.495
ANKRD28	ENSPCOP00000002776	ENSPCOP00000031380	ENSPCOP00000002776	Ankyrin repeat domain 28.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...]	0.418
ANKRD28	ENSPCOP00000025432	ENSPCOP00000031380	ENSPCOP00000025432	Ankyrin repeat domain 28.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...]	0.418