STRINGSTRING
SH3KBP1 SH3KBP1 PAG1 PAG1 ENSPCOP00000002686 ENSPCOP00000002686 ENSPCOP00000002927 ENSPCOP00000002927 LOC105820322 LOC105820322 UBA52 UBA52 EPS15 EPS15 EPN1 EPN1 AAMP AAMP AREG AREG NRAS NRAS LOC105823447 LOC105823447 HBEGF HBEGF SH3GL3 SH3GL3 TGFA TGFA STAM STAM PTPRM PTPRM STAM2 STAM2 LRIG3 LRIG3 SOS1 SOS1 KRAS KRAS HGS HGS FNDC3A FNDC3A CBL CBL CSDE1 CSDE1 ENSPCOP00000012718 ENSPCOP00000012718 PXN PXN EGF EGF PTPRT PTPRT PIK3CA PIK3CA EPGN EPGN RPS27A RPS27A GRB2 GRB2 EGFR EGFR PIK3R1 PIK3R1 SRC SRC ENSPCOP00000018904 ENSPCOP00000018904 BTC BTC HRAS HRAS FNDC3B FNDC3B ADAM10 ADAM10 LRIG2 LRIG2 PTPN12 PTPN12 CDC42 CDC42 EREG EREG ENSPCOP00000023542 ENSPCOP00000023542 PLCG1 PLCG1 SH3GL1 SH3GL1 SPRY1 SPRY1 SPRY2 SPRY2 LOC105816759 LOC105816759 LRIG1 LRIG1 PTPN11 PTPN11 ARHGEF7 ARHGEF7 SH3GL2 SH3GL2 ADAM17 ADAM17 TGFB1I1 TGFB1I1 CSK CSK PTPN3 PTPN3 SHC1 SHC1 EPS15L1 EPS15L1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SH3KBP1SH3 domain containing kinase binding protein 1. (708 aa)
PAG1Phosphoprotein membrane anchor with glycosphingolipid microdomains 1. (426 aa)
ENSPCOP00000002686CSD_1 domain-containing protein. (293 aa)
ENSPCOP00000002927Uncharacterized protein. (160 aa)
LOC105820322Ubiquitin-like domain-containing protein. (77 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
EPS15Uncharacterized protein. (842 aa)
EPN1Epsin 1. (575 aa)
AAMPAngio associated migratory cell protein. (391 aa)
AREGAmphiregulin. (253 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
LOC105823447Uncharacterized protein. (594 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
SH3GL3SH3 domain containing GRB2 like 3, endophilin A3. (358 aa)
TGFATransforming growth factor alpha. (190 aa)
STAMVHS domain-containing protein. (280 aa)
PTPRMProtein tyrosine phosphatase receptor type M. (1440 aa)
STAM2Signal transducing adaptor molecule 2. (525 aa)
LRIG3Leucine rich repeats and immunoglobulin like domains 3. (1120 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
KRASUncharacterized protein. (75 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (777 aa)
FNDC3AFibronectin type III domain containing 3A. (1044 aa)
CBLCbl proto-oncogene. (891 aa)
CSDE1Cold shock domain containing E1. (798 aa)
ENSPCOP00000012718Ubiquitin-like domain-containing protein. (74 aa)
PXNPaxillin. (1073 aa)
EGFEpidermal growth factor. (1132 aa)
PTPRTProtein tyrosine phosphatase receptor type T. (1379 aa)
PIK3CAPhosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
EPGNEpithelial mitogen. (153 aa)
RPS27ARibosomal protein S27a. (156 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
SRCTyrosine-protein kinase. (543 aa)
ENSPCOP00000018904Ubiquitin-like domain-containing protein. (131 aa)
BTCBetacellulin. (140 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
FNDC3BFibronectin type III domain containing 3B. (1156 aa)
ADAM10ADAM metallopeptidase domain 10. (748 aa)
LRIG2Leucine rich repeats and immunoglobulin like domains 2. (875 aa)
PTPN12Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. (705 aa)
CDC42Uncharacterized protein. (191 aa)
EREGEpiregulin. (166 aa)
ENSPCOP00000023542Ubiquitin-like domain-containing protein. (112 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1304 aa)
SH3GL1SH3 domain containing GRB2 like 1, endophilin A2. (368 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
SPRY2Sprouty RTK signaling antagonist 2. (314 aa)
LOC105816759Ubiquitin-like domain-containing protein. (156 aa)
LRIG1Leucine rich repeats and immunoglobulin like domains 1. (1063 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (782 aa)
SH3GL2SH3 domain containing GRB2 like 2, endophilin A1. (352 aa)
ADAM17ADAM metallopeptidase domain 17. (757 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (461 aa)
CSKTyrosine-protein kinase. (450 aa)
PTPN3Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (914 aa)
SHC1SHC adaptor protein 1. (582 aa)
EPS15L1Epidermal growth factor receptor pathway substrate 15 like 1. (910 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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