STRINGSTRING
PIP4K2C PIP4K2C RHOG RHOG PDGFB PDGFB ENSPCOP00000002561 ENSPCOP00000002561 PIP5K1B PIP5K1B FGFR1 FGFR1 SPEM1 SPEM1 FGF16 FGF16 PTEN PTEN PPP2R5E PPP2R5E FGF10 FGF10 TRAF6 TRAF6 STRN3 STRN3 PPP4R4 PPP4R4 FAM102B FAM102B TRIB3 TRIB3 PPP2R5C PPP2R5C PIP5K1A PIP5K1A PPP2R1A PPP2R1A CD28 CD28 GAB1 GAB1 ENSPCOP00000013862 ENSPCOP00000013862 IL1RAP IL1RAP IL33 IL33 VAV1 VAV1 EGF EGF CD19 CD19 PIK3CA PIK3CA EPGN EPGN PPP4R1 PPP4R1 PIK3CB PIK3CB FGF19 FGF19 SPEM2 SPEM2 FLT3LG FLT3LG GRB2 GRB2 LOC105822621 LOC105822621 HGF HGF EGFR EGFR PIK3R2 PIK3R2 PIP5KL1 PIP5KL1 PPP2R5D PPP2R5D PIK3R1 PIK3R1 SRC SRC AKT2 AKT2 BTC BTC FRS2 FRS2 PIP5K1C PIP5K1C CD86 CD86 FNDC3B FNDC3B BANK1 BANK1 NRG3 NRG3 IER3 IER3 PPP2R1B PPP2R1B GAB2 GAB2 MET MET KITLG KITLG PIP4K2A PIP4K2A NRG2 NRG2 EREG EREG CD276 CD276 PPP2R5A PPP2R5A ESR1 ESR1 KIT KIT FAM102A FAM102A FLT3 FLT3 FGF17 FGF17 PDGFA PDGFA ICOS ICOS INSC INSC PPP2CA PPP2CA INSR INSR LOC105820073 LOC105820073 PDGFRA PDGFRA FGF7 FGF7 PHLPP1 PHLPP1 KL KL FGF3 FGF3 ERBB3 ERBB3 FGFR3 FGFR3 ERBB2 ERBB2 FGFR4 FGFR4 AKT3 AKT3 IRAK4 IRAK4 PPP2R5B PPP2R5B PIP4K2B PIP4K2B AKT1 AKT1 IL1RL1 IL1RL1 IRAK1 IRAK1 ENSPCOP00000029403 ENSPCOP00000029403 PTPN11 PTPN11 STRN STRN THEM4 THEM4 MAPK1 MAPK1 PIK3CD PIK3CD FGFR2 FGFR2 MYD88 MYD88 PDGFRB PDGFRB STRN4 STRN4 FGF2 FGF2 FGF4 FGF4 FGF20 FGF20 ESR2 ESR2 LOC105805030 LOC105805030 FGF23 FGF23 AREG AREG KLB KLB WDR64 WDR64 FGF9 FGF9 HBEGF HBEGF PPP2CB PPP2CB NRG4 NRG4 TGFA TGFA PIK3R3 PIK3R3 MAPK3 MAPK3 FGF22 FGF22 PHLPP2 PHLPP2 FYN FYN NRG1 NRG1 FNBP4 FNBP4 RELCH RELCH LCK LCK FNDC3A FNDC3A FGF1 FGF1 PIK3AP1 PIK3AP1 INS INS LRRC40 LRRC40 FGF8 FGF8 CD80 CD80 FGF18 FGF18
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIP4K2CPhosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (421 aa)
RHOGRas homolog family member G. (191 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
ENSPCOP00000002561Uncharacterized protein. (546 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (540 aa)
FGFR1Fibroblast growth factor receptor. (846 aa)
SPEM1Spermatid maturation 1. (307 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
TRAF6TNF receptor-associated factor. (498 aa)
STRN3Striatin 3. (797 aa)
PPP4R4Protein phosphatase 4 regulatory subunit 4. (826 aa)
FAM102BFamily with sequence similarity 102 member B. (360 aa)
TRIB3Tribbles pseudokinase 3. (367 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (542 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (598 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
CD28CD28 molecule. (220 aa)
GAB1GRB2 associated binding protein 1. (683 aa)
ENSPCOP00000013862SER_THR_PHOSPHATASE domain-containing protein. (209 aa)
IL1RAPInterleukin 1 receptor accessory protein. (687 aa)
IL33Interleukin 33. (274 aa)
VAV1Vav guanine nucleotide exchange factor 1. (806 aa)
EGFEpidermal growth factor. (1132 aa)
CD19CD19 molecule. (557 aa)
PIK3CAPhosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
EPGNEpithelial mitogen. (153 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (906 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
SPEM2SPEM family member 2. (501 aa)
FLT3LGFms related tyrosine kinase 3 ligand. (237 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
LOC105822621Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (703 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
PIK3R2Uncharacterized protein. (726 aa)
PIP5KL1Phosphatidylinositol-4-phosphate 5-kinase like 1. (396 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (598 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
SRCTyrosine-protein kinase. (543 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
BTCBetacellulin. (140 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (682 aa)
CD86CD86 molecule. (336 aa)
FNDC3BFibronectin type III domain containing 3B. (1156 aa)
BANK1B cell scaffold protein with ankyrin repeats 1. (567 aa)
NRG3Neuregulin 3. (721 aa)
IER3Immediate early response 3. (156 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (552 aa)
GAB2GRB2 associated binding protein 2. (679 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1397 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
PIP4K2APhosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (406 aa)
NRG2Neuregulin 2. (850 aa)
EREGEpiregulin. (166 aa)
CD276CD276 molecule. (332 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (447 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (599 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
FAM102AFamily with sequence similarity 102 member A. (316 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (949 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
ICOSInducible T cell costimulator. (200 aa)
INSCINSC spindle orientation adaptor protein. (579 aa)
PPP2CASerine/threonine-protein phosphatase. (295 aa)
INSRInsulin receptor. (1192 aa)
LOC105820073WRNPLPNID domain-containing protein. (958 aa)
PDGFRAPlatelet derived growth factor receptor alpha; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1027 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
PHLPP1PH domain and leucine rich repeat protein phosphatase 1. (1710 aa)
KLKlotho. (988 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (233 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1337 aa)
FGFR3Fibroblast growth factor receptor. (807 aa)
ERBB2Receptor protein-tyrosine kinase. (1252 aa)
FGFR4Fibroblast growth factor receptor. (797 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (406 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (501 aa)
PIP4K2BPhosphatidylinositol-5-phosphate 4-kinase type 2 beta. (416 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IL1RL1Uncharacterized protein. (211 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (713 aa)
ENSPCOP00000029403Protein kinase domain-containing protein. (429 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
STRNStriatin. (657 aa)
THEM4Thioesterase superfamily member 4. (202 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
FGFR2Fibroblast growth factor receptor. (797 aa)
MYD88MYD88 innate immune signal transduction adaptor. (353 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1105 aa)
STRN4Striatin 4. (666 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (394 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
ESR2Estrogen receptor 2. (471 aa)
LOC105805030Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (150 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
AREGAmphiregulin. (253 aa)
KLBKlotho beta. (1032 aa)
WDR64WD repeat domain 64. (1081 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
NRG4Neuregulin 4. (116 aa)
TGFATransforming growth factor alpha. (190 aa)
PIK3R3Uncharacterized protein. (454 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (172 aa)
PHLPP2PH domain and leucine rich repeat protein phosphatase 2. (1320 aa)
FYNTyrosine-protein kinase. (537 aa)
NRG1Neuregulin 1. (710 aa)
FNBP4Formin binding protein 4. (870 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1217 aa)
LCKTyrosine-protein kinase. (417 aa)
FNDC3AFibronectin type III domain containing 3A. (1044 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
PIK3AP1Phosphoinositide-3-kinase adaptor protein 1. (805 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
LRRC40Leucine rich repeat containing 40. (565 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
CD80CD80 molecule. (265 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
Server load: low (12%) [HD]