STRINGSTRING
RASA1 RASA1 EPHB2 EPHB2 ENSPCOP00000000722 ENSPCOP00000000722 ENSPCOP00000000994 ENSPCOP00000000994 NCSTN NCSTN ARPC2 ARPC2 MYL9 MYL9 GIT1 GIT1 ENSPCOP00000002125 ENSPCOP00000002125 LOC105805812 LOC105805812 NCK2 NCK2 ENSPCOP00000002927 ENSPCOP00000002927 CLTC CLTC APH1B APH1B ARPC1B ARPC1B MYH9 MYH9 CFL2 CFL2 ENSPCOP00000004655 ENSPCOP00000004655 ACTB ACTB ARPC1A ARPC1A ARPC5L ARPC5L ENSPCOP00000005631 ENSPCOP00000005631 MYH14 MYH14 PSEN2 PSEN2 CLTB CLTB PAK1 PAK1 ROCK1 ROCK1 VAV2 VAV2 MMP2 MMP2 FYN FYN LOC105822409 LOC105822409 APH1A APH1A ACTL8 ACTL8 FNDC3A FNDC3A EPHA2 EPHA2 ARPC3 ARPC3 ARHGEF28 ARHGEF28 ACTR3B ACTR3B EFNB2 EFNB2 EFNA4 EFNA4 LOC105810750 LOC105810750 CLTA CLTA EFNB3 EFNB3 CLTCL1 CLTCL1 LIMK1 LIMK1 EPHA10 EPHA10 EPHA8 EPHA8 ITSN1 ITSN1 SRC SRC EPHB3 EPHB3 LOC105811778 LOC105811778 VAV3 VAV3 AP2B1 AP2B1 FNDC3B FNDC3B CFL1 CFL1 EPHB4 EPHB4 ADAM10 ADAM10 AP2S1 AP2S1 GRIN1 GRIN1 PAK2 PAK2 LOC105826870 LOC105826870 ACTG1 ACTG1 CDC42 CDC42 ARPC5 ARPC5 PAK3 PAK3 EPHA3 EPHA3 MYH10 MYH10 SDCBP2 SDCBP2 ACTR3 ACTR3 WASL WASL LYN LYN ENSPCOP00000024978 ENSPCOP00000024978 PTK2 PTK2 AP2A1 AP2A1 EPHA1 EPHA1 SDC2 SDC2 GRIN2B GRIN2B ACTR2 ACTR2 SDCBP SDCBP LIMK2 LIMK2 ENSPCOP00000027946 ENSPCOP00000027946 TIAM1 TIAM1 DNM1 DNM1 NGEF NGEF MYH11 MYH11 AP2M1 AP2M1 ARHGEF7 ARHGEF7 EFNA5 EFNA5 LOC105817025 LOC105817025 ENSPCOP00000030477 ENSPCOP00000030477 ENSPCOP00000030916 ENSPCOP00000030916 LOC105810942 LOC105810942 MYL12B MYL12B EFNA3 EFNA3 EFNB1 EFNB1 PSENEN PSENEN ENSPCOP00000011171 ENSPCOP00000011171 ROCK2 ROCK2 DSTN DSTN MMP9 MMP9 EPHA4 EPHA4 ARPC4 ARPC4 FMN1 FMN1 EPHB6 EPHB6 FMN2 FMN2 MYL12A MYL12A ENSPCOP00000013931 ENSPCOP00000013931 EFNA2 EFNA2 PSEN1 PSEN1 EPHB1 EPHB1 ENSPCOP00000014851 ENSPCOP00000014851 AP2A2 AP2A2 MYL6 MYL6 EFNA1 EFNA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RASA1RAS p21 protein activator 1. (623 aa)
EPHB2EPH receptor B2. (1039 aa)
ENSPCOP00000000722Protein kinase domain-containing protein. (67 aa)
ENSPCOP00000000994Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (173 aa)
NCSTNNicastrin. (708 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (292 aa)
MYL9Myosin light chain 9. (172 aa)
GIT1GIT ArfGAP 1. (752 aa)
ENSPCOP00000002125ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (149 aa)
LOC105805812Uncharacterized protein. (172 aa)
NCK2Cytoplasmic protein. (380 aa)
ENSPCOP00000002927Uncharacterized protein. (160 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1681 aa)
APH1BAph-1 homolog B, gamma-secretase subunit. (257 aa)
ARPC1BActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (372 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1967 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
ENSPCOP00000004655WD_REPEATS_REGION domain-containing protein. (262 aa)
ACTBActin beta. (378 aa)
ARPC1AUncharacterized protein. (188 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
ENSPCOP00000005631Protein kinase domain-containing protein. (159 aa)
MYH14Myosin heavy chain 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1995 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (482 aa)
CLTBClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (229 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
ROCK1Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1316 aa)
VAV2Vav guanine nucleotide exchange factor 2. (771 aa)
MMP2Matrix metallopeptidase 2. (552 aa)
FYNTyrosine-protein kinase. (537 aa)
LOC105822409Eph LBD domain-containing protein. (279 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
ACTL8Actin like 8; Belongs to the actin family. (351 aa)
FNDC3AFibronectin type III domain containing 3A. (1044 aa)
EPHA2EPH receptor A2. (976 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
ARHGEF28Rho guanine nucleotide exchange factor 28. (1702 aa)
ACTR3BUncharacterized protein; Belongs to the actin family. (353 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (335 aa)
EFNA4Ephrin A4; Belongs to the ephrin family. (201 aa)
LOC105810750B2-adapt-app_C domain-containing protein. (263 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (248 aa)
EFNB3Ephrin B3; Belongs to the ephrin family. (343 aa)
CLTCL1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1426 aa)
LIMK1LIM domain kinase 1. (678 aa)
EPHA10EPH receptor A10. (1008 aa)
EPHA8EPH receptor A8. (1006 aa)
ITSN1Intersectin 1. (1697 aa)
SRCTyrosine-protein kinase. (543 aa)
EPHB3EPH receptor B3. (1009 aa)
LOC105811778WD_REPEATS_REGION domain-containing protein. (354 aa)
VAV3Vav guanine nucleotide exchange factor 3. (765 aa)
AP2B1Uncharacterized protein. (809 aa)
FNDC3BFibronectin type III domain containing 3B. (1156 aa)
CFL1ADF-H domain-containing protein. (178 aa)
EPHB4EPH receptor B4. (987 aa)
ADAM10ADAM metallopeptidase domain 10. (748 aa)
AP2S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (184 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (960 aa)
PAK2Non-specific serine/threonine protein kinase. (492 aa)
LOC105826870Uncharacterized protein. (244 aa)
ACTG1Actin gamma 1. (404 aa)
CDC42Uncharacterized protein. (191 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (126 aa)
PAK3P21 (RAC1) activated kinase 3. (580 aa)
EPHA3EPH receptor A3. (831 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2007 aa)
SDCBP2Syndecan binding protein 2. (292 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (418 aa)
WASLWASP like actin nucleation promoting factor. (505 aa)
LYNTyrosine-protein kinase. (512 aa)
ENSPCOP00000024978ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (148 aa)
PTK2Protein tyrosine kinase 2. (1089 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (977 aa)
EPHA1EPH receptor A1. (942 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (201 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1485 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
SDCBPUncharacterized protein. (298 aa)
LIMK2LIM domain kinase 2. (638 aa)
ENSPCOP00000027946Uncharacterized protein. (298 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1590 aa)
DNM1Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (864 aa)
NGEFNeuronal guanine nucleotide exchange factor. (648 aa)
MYH11Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2030 aa)
AP2M1AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (452 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (782 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
LOC105817025ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (218 aa)
ENSPCOP00000030477PDZ domain-containing protein. (263 aa)
ENSPCOP00000030916Uncharacterized protein. (524 aa)
LOC105810942WD_REPEATS_REGION domain-containing protein. (347 aa)
MYL12BMyosin light chain 12B. (172 aa)
EFNA3Ephrin RBD domain-containing protein; Belongs to the ephrin family. (238 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (346 aa)
PSENENPresenilin enhancer, gamma-secretase subunit. (101 aa)
ENSPCOP00000011171Uncharacterized protein. (575 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1361 aa)
DSTNDestrin, actin depolymerizing factor; Belongs to the actin-binding proteins ADF family. (170 aa)
MMP9Matrix metallopeptidase 9. (709 aa)
EPHA4EPH receptor A4. (976 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (186 aa)
FMN1Formin 1. (1370 aa)
EPHB6EPH receptor B6. (1019 aa)
FMN2Formin 2. (1572 aa)
MYL12AUncharacterized protein. (172 aa)
ENSPCOP00000013931Eph LBD domain-containing protein. (358 aa)
EFNA2Ephrin A2; Belongs to the ephrin family. (211 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
EPHB1EPH receptor B1. (984 aa)
ENSPCOP00000014851Fibronectin type-II domain-containing protein. (75 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (939 aa)
MYL6Myosin light chain 6. (209 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (205 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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