STRINGSTRING
ITSN1 ITSN1 ACTR3B ACTR3B EFNB2 EFNB2 RASA1 RASA1 EPHB2 EPHB2 ENSPCOP00000000722 ENSPCOP00000000722 ENSPCOP00000000994 ENSPCOP00000000994 ARPC2 ARPC2 ENSPCOP00000002125 ENSPCOP00000002125 ENSPCOP00000002927 ENSPCOP00000002927 ARPC1B ARPC1B CFL2 CFL2 ENSPCOP00000004655 ENSPCOP00000004655 ACTB ACTB ARPC1A ARPC1A ARPC5L ARPC5L PAK1 PAK1 ROCK1 ROCK1 FYN FYN ACTL8 ACTL8 FNDC3A FNDC3A ARPC3 ARPC3 ARHGEF28 ARHGEF28 ROCK2 ROCK2 DSTN DSTN ARPC4 ARPC4 FMN1 FMN1 EPHB6 EPHB6 FMN2 FMN2 EPHB1 EPHB1 EFNB3 EFNB3 LIMK1 LIMK1 SRC SRC EPHB3 EPHB3 LOC105811778 LOC105811778 FNDC3B FNDC3B CFL1 CFL1 EPHB4 EPHB4 GRIN1 GRIN1 ACTG1 ACTG1 CDC42 CDC42 ARPC5 ARPC5 ACTR3 ACTR3 WASL WASL LYN LYN ENSPCOP00000024978 ENSPCOP00000024978 PTK2 PTK2 SDC2 SDC2 GRIN2B GRIN2B ACTR2 ACTR2 LIMK2 LIMK2 ENSPCOP00000027946 ENSPCOP00000027946 TIAM1 TIAM1 LOC105817025 LOC105817025 LOC105810942 LOC105810942 EFNB1 EFNB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITSN1Intersectin 1. (1697 aa)
ACTR3BUncharacterized protein; Belongs to the actin family. (353 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (335 aa)
RASA1RAS p21 protein activator 1. (623 aa)
EPHB2EPH receptor B2. (1039 aa)
ENSPCOP00000000722Protein kinase domain-containing protein. (67 aa)
ENSPCOP00000000994Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (173 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (292 aa)
ENSPCOP00000002125ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (149 aa)
ENSPCOP00000002927Uncharacterized protein. (160 aa)
ARPC1BActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (372 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
ENSPCOP00000004655WD_REPEATS_REGION domain-containing protein. (262 aa)
ACTBActin beta. (378 aa)
ARPC1AUncharacterized protein. (188 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
ROCK1Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1316 aa)
FYNTyrosine-protein kinase. (537 aa)
ACTL8Actin like 8; Belongs to the actin family. (351 aa)
FNDC3AFibronectin type III domain containing 3A. (1044 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
ARHGEF28Rho guanine nucleotide exchange factor 28. (1702 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1361 aa)
DSTNDestrin, actin depolymerizing factor; Belongs to the actin-binding proteins ADF family. (170 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (186 aa)
FMN1Formin 1. (1370 aa)
EPHB6EPH receptor B6. (1019 aa)
FMN2Formin 2. (1572 aa)
EPHB1EPH receptor B1. (984 aa)
EFNB3Ephrin B3; Belongs to the ephrin family. (343 aa)
LIMK1LIM domain kinase 1. (678 aa)
SRCTyrosine-protein kinase. (543 aa)
EPHB3EPH receptor B3. (1009 aa)
LOC105811778WD_REPEATS_REGION domain-containing protein. (354 aa)
FNDC3BFibronectin type III domain containing 3B. (1156 aa)
CFL1ADF-H domain-containing protein. (178 aa)
EPHB4EPH receptor B4. (987 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (960 aa)
ACTG1Actin gamma 1. (404 aa)
CDC42Uncharacterized protein. (191 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (126 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (418 aa)
WASLWASP like actin nucleation promoting factor. (505 aa)
LYNTyrosine-protein kinase. (512 aa)
ENSPCOP00000024978ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (148 aa)
PTK2Protein tyrosine kinase 2. (1089 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (201 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1485 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
LIMK2LIM domain kinase 2. (638 aa)
ENSPCOP00000027946Uncharacterized protein. (298 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1590 aa)
LOC105817025ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (218 aa)
LOC105810942WD_REPEATS_REGION domain-containing protein. (347 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (346 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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