STRINGSTRING
MAPKAPK3 MAPKAPK3 CDH5 CDH5 AKT2 AKT2 NCKAP1L NCKAP1L ITPR3 ITPR3 SRC SRC ENSPCOP00000018566 ENSPCOP00000018566 PIK3R1 PIK3R1 PIK3R2 PIK3R2 CRK CRK LOC105812452 LOC105812452 BRK1 BRK1 MAPK14 MAPK14 PIK3CB PIK3CB WASF3 WASF3 MLST8 MLST8 PIK3CA PIK3CA CASS4 CASS4 MAPK11 MAPK11 VAV1 VAV1 NCF4 NCF4 MAPK12 MAPK12 SHC2 SHC2 WASF2 WASF2 PXN PXN CSDE1 CSDE1 JUP JUP NEDD9 NEDD9 ROCK2 ROCK2 ITGAV ITGAV SPHK1 SPHK1 ENSPCOP00000010513 ENSPCOP00000010513 PAK2 PAK2 BAIAP2 BAIAP2 MAPKAP1 MAPKAP1 FNDC3A FNDC3A ACTL8 ACTL8 NOS3 NOS3 KRAS KRAS ENSPCOP00000009588 ENSPCOP00000009588 LOC105819868 LOC105819868 FYN FYN ABI1 ABI1 VAV2 VAV2 ROCK1 ROCK1 NCF1 NCF1 PAK1 PAK1 CYFIP1 CYFIP1 SH2D2A SH2D2A STX12 STX12 PRKACB PRKACB MAPKAPK2 MAPKAPK2 NRAS NRAS KDR KDR ACTG1 ACTG1 CDC42 CDC42 CTNNB1 CTNNB1 PAK3 PAK3 SHD SHD AXL AXL ABI2 ABI2 VEGFA VEGFA CYBA CYBA SHE SHE PLCG1 PLCG1 CAV1 CAV1 ITPR1 ITPR1 AHCYL1 AHCYL1 PTK2 PTK2 STX7 STX7 ARVCF ARVCF PRKCD PRKCD PTK2B PTK2B ELMO3 ELMO3 ELMO1 ELMO1 AKT3 AKT3 PRKACA PRKACA AKT1 AKT1 PRKCA PRKCA PRKCB PRKCB EFS EFS THEM4 THEM4 TGFB1I1 TGFB1I1 RICTOR RICTOR MAPK13 MAPK13 CTNNA1 CTNNA1 HSPB1 HSPB1 HSP90AA1 HSP90AA1 ELMO2 ELMO2 SHF SHF CYFIP2 CYFIP2 PDPK1 PDPK1 ACTB ACTB WASF1 WASF1 ITPR2 ITPR2 ENSPCOP00000002927 ENSPCOP00000002927 NCK2 NCK2 ENSPCOP00000002686 ENSPCOP00000002686 CYBB CYBB LOC105822640 LOC105822640 NCKAP1 NCKAP1 SHB SHB MTOR MTOR PRKCZ PRKCZ NCK1 NCK1 BCAR1 BCAR1 RASA1 RASA1 TRIB3 TRIB3 CTNND1 CTNND1 FNDC3B FNDC3B HRAS HRAS VAV3 VAV3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (384 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (786 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
NCKAP1LNCK associated protein 1 like. (1138 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2664 aa)
SRCTyrosine-protein kinase. (543 aa)
ENSPCOP00000018566Uncharacterized protein. (113 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIK3R2Uncharacterized protein. (726 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
LOC105812452HATPase_c domain-containing protein. (680 aa)
BRK1BRICK1 subunit of SCAR/WAVE actin nucleating complex. (75 aa)
MAPK14Mitogen-activated protein kinase 14. (340 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
WASF3WASP family member 3. (485 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
PIK3CAPhosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
CASS4Cas scaffold protein family member 4. (774 aa)
MAPK11Mitogen-activated protein kinase. (443 aa)
VAV1Vav guanine nucleotide exchange factor 1. (806 aa)
NCF4Neutrophil cytosolic factor 4. (306 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
SHC2Uncharacterized protein. (578 aa)
WASF2WASP family member 2. (497 aa)
PXNPaxillin. (1073 aa)
CSDE1Cold shock domain containing E1. (798 aa)
JUPJunction plakoglobin. (745 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (834 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1361 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1047 aa)
SPHK1Sphingosine kinase 1. (469 aa)
ENSPCOP00000010513SH2 domain-containing protein. (85 aa)
PAK2Non-specific serine/threonine protein kinase. (492 aa)
BAIAP2BAI1 associated protein 2. (544 aa)
MAPKAP1MAPK associated protein 1. (492 aa)
FNDC3AFibronectin type III domain containing 3A. (1044 aa)
ACTL8Actin like 8; Belongs to the actin family. (351 aa)
NOS3Nitric oxide synthase 3. (994 aa)
KRASUncharacterized protein. (75 aa)
ENSPCOP00000009588Uncharacterized protein. (316 aa)
LOC105819868Protein kinase domain-containing protein. (302 aa)
FYNTyrosine-protein kinase. (537 aa)
ABI1Abl interactor 1. (508 aa)
VAV2Vav guanine nucleotide exchange factor 2. (771 aa)
ROCK1Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1316 aa)
NCF1Neutrophil cytosolic factor 1. (390 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1244 aa)
SH2D2ASH2 domain containing 2A. (378 aa)
STX12Syntaxin 12; Belongs to the syntaxin family. (276 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (399 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (400 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
ACTG1Actin gamma 1. (404 aa)
CDC42Uncharacterized protein. (191 aa)
CTNNB1Catenin beta 1. (781 aa)
PAK3P21 (RAC1) activated kinase 3. (580 aa)
SHDSrc homology 2 domain containing transforming protein D. (341 aa)
AXLAXL receptor tyrosine kinase. (894 aa)
ABI2Abl interactor 2. (513 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
CYBACytochrome b-245 alpha chain. (129 aa)
SHESrc homology 2 domain containing E. (497 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1304 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2732 aa)
AHCYL1Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family. (530 aa)
PTK2Protein tyrosine kinase 2. (1089 aa)
STX7Syntaxin 7. (173 aa)
ARVCFARVCF delta catenin family member. (965 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (967 aa)
ELMO3Engulfment and cell motility 3. (748 aa)
ELMO1Engulfment and cell motility 1. (727 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PRKCAUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (575 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
EFSEmbryonal Fyn-associated substrate. (561 aa)
THEM4Thioesterase superfamily member 4. (202 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (461 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1646 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
CTNNA1Catenin alpha 1. (906 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (206 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (816 aa)
ELMO2Engulfment and cell motility 2. (720 aa)
SHFSrc homology 2 domain containing F. (422 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (558 aa)
ACTBActin beta. (378 aa)
WASF1WASP family member 1. (559 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2702 aa)
ENSPCOP00000002927Uncharacterized protein. (160 aa)
NCK2Cytoplasmic protein. (380 aa)
ENSPCOP00000002686CSD_1 domain-containing protein. (293 aa)
CYBBCytochrome b-245 beta chain. (533 aa)
LOC105822640Integrin beta; Belongs to the integrin beta chain family. (454 aa)
NCKAP1NCK associated protein 1. (1006 aa)
SHBSH2 domain-containing protein. (509 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2536 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
NCK1Cytoplasmic protein. (377 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (902 aa)
RASA1RAS p21 protein activator 1. (623 aa)
TRIB3Tribbles pseudokinase 3. (367 aa)
CTNND1Catenin delta 1. (984 aa)
FNDC3BFibronectin type III domain containing 3B. (1156 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
VAV3Vav guanine nucleotide exchange factor 3. (765 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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