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| | PIP4P2 | Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (257 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (621 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa) |
| | SMYD2 | SET and MYND domain containing 2. (375 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | TP63 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa) |
| | TAF4 | TATA-box binding protein associated factor 4. (636 aa) |
| | RICTOR | RPTOR independent companion of MTOR complex 2. (1646 aa) |
| | USP7 | Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1111 aa) |
| | L3MBTL1 | Uncharacterized protein. (839 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | PIP4K2B | Phosphatidylinositol-5-phosphate 4-kinase type 2 beta. (416 aa) |
| | ENSPCOP00000028894 | TAFII55_N domain-containing protein. (314 aa) |
| | DNA2 | Uncharacterized protein. (833 aa) |
| | RFC2 | Replication factor C subunit 2. (352 aa) |
| | ATRIP | ATR interacting protein. (790 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | PRKAG2 | Protein kinase AMP-activated non-catalytic subunit gamma 2. (540 aa) |
| | MDM2 | Uncharacterized protein. (68 aa) |
| | HIPK1 | Homeodomain interacting protein kinase 1. (1131 aa) |
| | TAF13 | TATA-box binding protein associated factor 13. (124 aa) |
| | TAF10 | Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa) |
| | LOC105816759 | Ubiquitin-like domain-containing protein. (156 aa) |
| | PRKAA2 | Non-specific serine/threonine protein kinase. (553 aa) |
| | ENSPCOP00000027187 | SAM domain-containing protein. (411 aa) |
| | TAF6 | TATA-box binding protein associated factor 6. (732 aa) |
| | CHEK2 | Checkpoint kinase 2. (571 aa) |
| | AIRE | Autoimmune regulator. (544 aa) |
| | RNF34 | Ring finger protein 34. (489 aa) |
| | MEAF6 | MYST/Esa1 associated factor 6. (201 aa) |
| | CDK5 | Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa) |
| | BRD1 | Bromodomain containing 1. (1195 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (442 aa) |
| | EHMT1 | Euchromatic histone lysine methyltransferase 1. (1287 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (345 aa) |
| | PPP2CA | Serine/threonine-protein phosphatase. (295 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa) |
| | DYRK4 | Dual specificity tyrosine phosphorylation regulated kinase 4. (513 aa) |
| | RBBP4 | RB binding protein 4, chromatin remodeling factor. (425 aa) |
| | CSNK2A2 | Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (356 aa) |
| | ENSPCOP00000024841 | Uncharacterized protein. (84 aa) |
| | POU4F1 | POU domain protein. (421 aa) |
| | ZNF385B | Zinc finger protein 385B. (471 aa) |
| | MDM4 | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (491 aa) |
| | FOXP4 | Forkhead box P4. (668 aa) |
| | DYRK3 | Dual specificity tyrosine phosphorylation regulated kinase 3. (588 aa) |
| | TBP | TATA-box binding protein. (335 aa) |
| | TXNDC11 | Thioredoxin domain containing 11. (987 aa) |
| | PRKAA1 | Non-specific serine/threonine protein kinase. (574 aa) |
| | MAPKAPK5 | MAPK activated protein kinase 5. (478 aa) |
| | ENSPCOP00000023542 | Ubiquitin-like domain-containing protein. (112 aa) |
| | ENSPCOP00000023392 | Uncharacterized protein. (157 aa) |
| | HIPK4 | Homeodomain interacting protein kinase 4; Belongs to the protein kinase superfamily. (397 aa) |
| | CSNK2A1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (475 aa) |
| | TP53INP1 | Tumor protein p53 inducible nuclear protein 1. (241 aa) |
| | RBBP7 | RB binding protein 7, chromatin remodeling factor. (469 aa) |
| | NUAK2 | NUAK family kinase 2. (676 aa) |
| | NUAK1 | NUAK family kinase 1. (667 aa) |
| | PIP4K2A | Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (406 aa) |
| | CDK3 | Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (304 aa) |
| | ENSPCOP00000022360 | FHA domain-containing protein. (60 aa) |
| | ZNF385C | Zinc finger protein 385C. (499 aa) |
| | SSRP1 | FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (709 aa) |
| | TAF7L | TATA-box binding protein associated factor 7 like. (440 aa) |
| | DYRK2 | Dual specificity tyrosine phosphorylation regulated kinase 2. (601 aa) |
| | TAF3 | TATA-box binding protein associated factor 3. (805 aa) |
| | CHD5 | Chromodomain helicase DNA binding protein 5. (1954 aa) |
| | MAPKAP1 | MAPK associated protein 1. (492 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1394 aa) |
| | KAT6A | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2007 aa) |
| | RPA3 | Replication protein A3. (107 aa) |
| | PPP1R13L | Protein phosphatase 1 regulatory subunit 13 like. (803 aa) |
| | PPP2R1B | Protein phosphatase 2 scaffold subunit Abeta. (552 aa) |
| | MTA2 | Metastasis associated 1 family member 2. (668 aa) |
| | PML | Promyelocytic leukemia. (887 aa) |
| | LY6G5B | Lymphocyte antigen 6 family member G5B. (201 aa) |
| | USP2 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (605 aa) |
| | EP300 | E1A binding protein p300. (2424 aa) |
| | MBD3 | Methyl-CpG binding domain protein 3. (253 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (416 aa) |
| | SGK1 | Non-specific serine/threonine protein kinase. (502 aa) |
| | TP53RK | TP53 regulating kinase. (253 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | ENSPCOP00000018904 | Ubiquitin-like domain-containing protein. (131 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (393 aa) |
| | TP53INP2 | Tumor protein p53 inducible nuclear protein 2. (221 aa) |
| | PHF20 | PHD finger protein 20. (1012 aa) |
| | CHD3 | Chromodomain helicase DNA binding protein 3. (2054 aa) |
| | PRKAG3 | Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa) |
| | TPX2 | TPX2 microtubule nucleation factor. (761 aa) |
| | ATM | ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2635 aa) |
| | MAPK14 | Mitogen-activated protein kinase 14. (340 aa) |
| | ING2 | Inhibitor of growth protein. (281 aa) |
| | RFC5 | AAA domain-containing protein. (338 aa) |
| | RFC4 | Replication factor C subunit 4. (365 aa) |
| | BRPF3 | Bromodomain and PHD finger containing 3. (1205 aa) |
| | CHEK1 | Checkpoint kinase 1. (454 aa) |
| | PIP4P1 | Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (290 aa) |
| | TDRD3 | Tudor domain containing 3. (554 aa) |
| | LOC105816059 | Uncharacterized protein. (256 aa) |
| | RPS27A | Ribosomal protein S27a. (156 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2643 aa) |
| | GATAD2A | GATA zinc finger domain containing 2A. (630 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | NOC2L | NOC2 like nucleolar associated transcriptional repressor. (744 aa) |
| | MLST8 | MTOR associated protein, LST8 homolog. (326 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1059 aa) |
| | L3MBTL3 | L3MBTL histone methyl-lysine binding protein 3. (759 aa) |
| | CSNK2B | Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (235 aa) |
| | JMY | Junction mediating and regulatory protein, p53 cofactor. (935 aa) |
| | TAF4B | TATA-box binding protein associated factor 4b. (808 aa) |
| | ING1 | Inhibitor of growth protein. (279 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (443 aa) |
| | AURKB | Protein kinase domain-containing protein. (162 aa) |
| | HUS1B | Checkpoint protein; Belongs to the HUS1 family. (253 aa) |
| | BANP | BTG3 associated nuclear protein. (503 aa) |
| | CHD4 | Uncharacterized protein. (1899 aa) |
| | ENSPCOP00000013862 | SER_THR_PHOSPHATASE domain-containing protein. (209 aa) |
| | LOC105812777 | Uncharacterized protein. (436 aa) |
| | TP73 | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (588 aa) |
| | SETD9 | SET domain containing 9. (299 aa) |
| | RMI2 | RecQ mediated genome instability 2. (150 aa) |
| | TAF12 | TATA-box binding protein associated factor 12. (213 aa) |
| | ENSPCOP00000012718 | Ubiquitin-like domain-containing protein. (74 aa) |
| | PIP4K2C | Phosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (421 aa) |
| | HIPK3 | Homeodomain interacting protein kinase 3. (1129 aa) |
| | ENSPCOP00000012342 | RING-type domain-containing protein. (80 aa) |
| | PIN1 | Peptidyl-prolyl cis-trans isomerase. (163 aa) |
| | TAF2 | TATA-box binding protein associated factor 2. (1025 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (865 aa) |
| | PRMT5 | Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (637 aa) |
| | BRD7 | Bromodomain containing 7. (652 aa) |
| | ENSPCOP00000011613 | Uncharacterized protein. (305 aa) |
| | CCNG1 | Cyclin G1. (151 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) |
| | LOC105819868 | Protein kinase domain-containing protein. (302 aa) |
| | LOC105805710 | TAFII55_N domain-containing protein. (337 aa) |
| | DAXX | Death domain associated protein. (739 aa) |
| | POU4F3 | POU domain protein. (338 aa) |
| | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (542 aa) |
| | BLM | BLM RecQ like helicase. (1352 aa) |
| | ENSPCOP00000000308 | Uncharacterized protein. (257 aa) |
| | RAD1 | Uncharacterized protein. (282 aa) |
| | ENSPCOP00000000328 | Uncharacterized protein. (67 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) |
| | NBN | Nbs1_C domain-containing protein. (429 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (769 aa) |
| | CDK5R1 | Cyclin-dependent kinase 5 activator. (306 aa) |
| | PRDM1 | PR/SET domain 1. (789 aa) |
| | MEIOB | Meiosis specific with OB-fold. (289 aa) |
| | TAF5 | TATA-box binding protein associated factor 5. (800 aa) |
| | EXO1 | Exonuclease 1. (835 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (241 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2536 aa) |
| | PLK5 | Polo like kinase 5. (337 aa) |
| | SUPT16H | SPT16 homolog, facilitates chromatin remodeling subunit. (1047 aa) |
| | LOC105811447 | SAM domain-containing protein. (553 aa) |
| | TAF15 | TATA-box binding protein associated factor 15. (584 aa) |
| | ENSPCOP00000002561 | Uncharacterized protein. (546 aa) |
| | TAF1 | Bromo domain-containing protein. (1722 aa) |
| | TTC5 | Tetratricopeptide repeat domain 5. (440 aa) |
| | TAF9B | TATA-box binding protein associated factor 9b. (251 aa) |
| | PRKAB1 | Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa) |
| | LOC105820322 | Ubiquitin-like domain-containing protein. (77 aa) |
| | PPP2R1A | Protein phosphatase 2 scaffold subunit Aalpha. (589 aa) |
| | C17orf113 | Chromosome 17 open reading frame 113. (675 aa) |
| | STK11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (442 aa) |
| | HIPK2 | Homeodomain interacting protein kinase 2. (1187 aa) |
| | POU4F2 | POU domain protein. (408 aa) |
| | ENSPCOP00000003978 | Uncharacterized protein. (482 aa) |
| | EHMT2 | Euchromatic histone lysine methyltransferase 2. (1267 aa) |
| | UBA52 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa) |
| | WRN | WRN RecQ like helicase. (1049 aa) |
| | AURKC | Protein kinase domain-containing protein. (164 aa) |
| | ENSPCOP00000004787 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (445 aa) |
| | PDPK1 | 3-phosphoinositide dependent protein kinase 1. (558 aa) |
| | ENSPCOP00000005162 | WD_REPEATS_REGION domain-containing protein. (355 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1003 aa) |
| | RECQL4 | RecQ like helicase 4. (842 aa) |
| | PPP1R13B | Protein phosphatase 1 regulatory subunit 13B. (1088 aa) |
| | PRKAG1 | Protein kinase AMP-activated non-catalytic subunit gamma 1. (331 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (432 aa) |
| | RFFL | Ring finger and FYVE like domain containing E3 ubiquitin protein ligase. (362 aa) |
| | BRD9 | Bromodomain containing 9. (589 aa) |
| | PPP2CB | Serine/threonine-protein phosphatase. (309 aa) |
| | KMT5A | SET domain-containing protein. (352 aa) |
| | ZNF385A | Zinc finger protein 385A. (414 aa) |
| | PRKAB2 | Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa) |
| | TAF11 | TATA-box binding protein associated factor 11. (211 aa) |
| | LOC105812775 | SWIB domain-containing protein. (243 aa) |
| | BRPF1 | Bromodomain and PHD finger containing 1. (1219 aa) |
| | ENSPCOP00000007712 | Protein kinase domain-containing protein. (266 aa) |
| | AURKA | Aurora kinase A; Belongs to the protein kinase superfamily. (402 aa) |
| | ENSPCOP00000008190 | AAA domain-containing protein. (331 aa) |
| | CDK1 | Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (709 aa) |
| | TBPL1 | TATA-box binding protein like 1. (186 aa) |
| | GATAD2B | GATA zinc finger domain containing 2B. (481 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa) |
| | PLK3 | Serine/threonine-protein kinase PLK. (672 aa) |
