Your Input: | |
| | RECQL4 | RecQ like helicase 4. (842 aa) |
| | LOC105805726 | Histone domain-containing protein; Belongs to the histone H2B family. (126 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1003 aa) |
| | PPP4C | Serine/threonine-protein phosphatase. (307 aa) |
| | LOC105805692 | Histone H2B type 1. (126 aa) |
| | ENSPCOP00000005384 | annotation not available (103 aa) |
| | XRCC4 | X-ray repair cross complementing 4. (297 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1286 aa) |
| | ENSPCOP00000005069 | annotation not available (103 aa) |
| | APBB1 | Amyloid beta precursor protein binding family B member 1. (714 aa) |
| | TDRD3 | Tudor domain containing 3. (554 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (879 aa) |
| | WRN | WRN RecQ like helicase. (1049 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (346 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | UBA52 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa) |
| | KPNA2 | Importin subunit alpha; Functions in nuclear protein import. (479 aa) |
| | ENSPCOP00000004429 | TPR_REGION domain-containing protein. (408 aa) |
| | ENSPCOP00000003978 | Uncharacterized protein. (482 aa) |
| | LOC105806826 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (146 aa) |
| | H2BC9 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSPCOP00000003703 | annotation not available (103 aa) |
| | LOC105820322 | Ubiquitin-like domain-containing protein. (77 aa) |
| | LOC105805647 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | BRCC3 | BRCA1/BRCA2-containing complex subunit 3. (313 aa) |
| | LOC105821920 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSPCOP00000003286 | RING-type domain-containing protein. (231 aa) |
| | EYA3 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa) |
| | ENSPCOP00000002972 | annotation not available (103 aa) |
| | ENSPCOP00000002858 | annotation not available (103 aa) |
| | LOC105805699 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | PALB2 | Partner and localizer of BRCA2. (1187 aa) |
| | LOC105805686 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC105809196 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (89 aa) |
| | LOC105805691 | Histone H2B; Belongs to the histone H2B family. (132 aa) |
| | SUMO1 | Small ubiquitin-related modifier. (101 aa) |
| | LOC105805703 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (241 aa) |
| | LOC105808155 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (465 aa) |
| | LOC105808154 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | EXO1 | Exonuclease 1. (835 aa) |
| | MEIOB | Meiosis specific with OB-fold. (289 aa) |
| | ENSPCOP00000000763 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (268 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (769 aa) |
| | LOC105805688 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | NBN | Nbs1_C domain-containing protein. (429 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) |
| | LOC105805690 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | RAD1 | Uncharacterized protein. (282 aa) |
| | ENSPCOP00000000308 | Uncharacterized protein. (257 aa) |
| | BLM | BLM RecQ like helicase. (1352 aa) |
| | H2BC15 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | RPS27A | Ribosomal protein S27a. (156 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2643 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | KDM4A | Uncharacterized protein. (1064 aa) |
| | PPP5C | Serine/threonine-protein phosphatase. (499 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1059 aa) |
| | POLL | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (573 aa) |
| | BABAM1 | BRISC and BRCA1 A complex member 1. (329 aa) |
| | POLD1 | DNA polymerase. (1125 aa) |
| | PPP4R2 | Protein phosphatase 4 regulatory subunit 2. (417 aa) |
| | SUMO3 | Small ubiquitin-related modifier. (120 aa) |
| | EYA4 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (522 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2284 aa) |
| | HUS1B | Checkpoint protein; Belongs to the HUS1 family. (253 aa) |
| | TIMELESS | Timeless circadian regulator. (1204 aa) |
| | ENSPCOP00000013947 | Small ubiquitin-related modifier. (91 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (551 aa) |
| | ENSPCOP00000013418 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (88 aa) |
| | DCLRE1C | DNA cross-link repair 1C. (691 aa) |
| | RMI2 | RecQ mediated genome instability 2. (150 aa) |
| | CLSPN | Claspin. (1329 aa) |
| | ENSPCOP00000012718 | Ubiquitin-like domain-containing protein. (74 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (304 aa) |
| | ENSPCOP00000012342 | RING-type domain-containing protein. (80 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (865 aa) |
| | POLE4 | DNA polymerase epsilon 4, accessory subunit. (118 aa) |
| | RAD51AP1 | RAD51 associated protein 1. (231 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1806 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa) |
| | RNF169 | Ring finger protein 169. (707 aa) |
| | LOC105817821 | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (689 aa) |
| | POLH | DNA polymerase eta. (709 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | UIMC1 | Ubiquitin interaction motif containing 1. (723 aa) |
| | EYA1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (709 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3419 aa) |
| | ENSPCOP00000008190 | AAA domain-containing protein. (331 aa) |
| | SLX1A | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (273 aa) |
| | RAD51 | RAD51 recombinase; Belongs to the RecA family. (340 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1974 aa) |
| | LOC105812100 | IBB domain-containing protein. (387 aa) |
| | HERC2 | HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4808 aa) |
| | ENSPCOP00000006619 | Uncharacterized protein. (177 aa) |
| | ENSPCOP00000006301 | Histone domain-containing protein; Belongs to the histone H2B family. (145 aa) |
| | PARP3 | Poly [ADP-ribose] polymerase. (520 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (432 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4130 aa) |
| | TDP1 | Tyrosyl-DNA phosphodiesterase 1. (608 aa) |
| | LOC105805697 | Histone H4. (103 aa) |
| | XRCC5 | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (677 aa) |
| | POLM | DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (491 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (298 aa) |
| | BAZ1B | Bromodomain adjacent to zinc finger domain 1B. (1482 aa) |
| | SIRT6 | Sirtuin 6. (305 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (621 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa) |
| | SLC23A3 | Solute carrier family 23 member 3. (618 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | RIF1 | Replication timing regulatory factor 1. (2476 aa) |
| | ENSPCOP00000030080 | FHA domain-containing protein. (142 aa) |
| | LOC105824194 | Ubiquitin-like domain-containing protein. (101 aa) |
| | POLK | DNA polymerase kappa. (832 aa) |
| | POLE3 | DNA polymerase epsilon 3, accessory subunit. (147 aa) |
| | XRCC6 | X-ray repair cross complementing 6. (496 aa) |
| | POLE2 | DNA polymerase epsilon 2, accessory subunit. (439 aa) |
| | DNTT | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (511 aa) |
| | DNA2 | Uncharacterized protein. (833 aa) |
| | RFC2 | Replication factor C subunit 2. (352 aa) |
| | ATRIP | ATR interacting protein. (790 aa) |
| | NHEJ1 | Non-homologous end joining factor 1. (299 aa) |
| | H2BC11 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSPCOP00000028467 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | LOC105805698 | Histone H4. (103 aa) |
| | MAPK8 | Mitogen-activated protein kinase 8. (346 aa) |
| | SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1023 aa) |
| | ENSPCOP00000028227 | annotation not available (103 aa) |
| | ENSPCOP00000028220 | annotation not available (103 aa) |
| | BAP1 | Ubiquitin carboxyl-terminal hydrolase. (730 aa) |
| | H3-4 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | RFC1 | Replication factor C subunit 1. (1113 aa) |
| | LOC105816759 | Ubiquitin-like domain-containing protein. (156 aa) |
| | LOC105816693 | Histone H4. (103 aa) |
| | CHEK2 | Checkpoint kinase 2. (571 aa) |
| | LIG3 | DNA ligase. (966 aa) |
| | ENSPCOP00000026686 | DUF4502 domain-containing protein. (122 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (442 aa) |
| | LOC105824056 | Uncharacterized protein. (63 aa) |
| | TMEM182 | Transmembrane protein 182. (133 aa) |
| | XRCC1 | X-ray repair cross complementing 1. (598 aa) |
| | ENSPCOP00000024945 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (97 aa) |
| | POLQ | DNA polymerase theta. (2280 aa) |
| | ENSPCOP00000024841 | Uncharacterized protein. (84 aa) |
| | LOC105824086 | DUF4503 domain-containing protein. (397 aa) |
| | POLD3 | DNA polymerase delta 3, accessory subunit. (359 aa) |
| | PARP2 | Poly [ADP-ribose] polymerase. (581 aa) |
| | RAD51B | RECA_2 domain-containing protein. (199 aa) |
| | SIRT7 | Sirtuin 7. (400 aa) |
| | ENSPCOP00000023835 | Uncharacterized protein. (59 aa) |
| | ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (410 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (504 aa) |
| | ENSPCOP00000023542 | Ubiquitin-like domain-containing protein. (112 aa) |
| | RAD51C | RAD51 paralog C. (368 aa) |
| | ENSPCOP00000023392 | Uncharacterized protein. (157 aa) |
| | LOC105825161 | RECA_2 domain-containing protein. (281 aa) |
| | POLD4 | Uncharacterized protein. (107 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (475 aa) |
| | RCBTB1 | RCC1 and BTB domain containing protein 1. (531 aa) |
| | EYA2 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (539 aa) |
| | ENSPCOP00000022568 | Uncharacterized protein; Belongs to the histone H2B family. (103 aa) |
| | CDK3 | Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (304 aa) |
| | ENSPCOP00000022360 | FHA domain-containing protein. (60 aa) |
| | H2BC5 | Histone H2B; Belongs to the histone H2B family. (131 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (473 aa) |
| | PAXIP1 | PAX interacting protein 1. (1043 aa) |
| | CNPPD1 | Cyclin Pas1/PHO80 domain containing 1. (410 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1394 aa) |
| | ENSPCOP00000021297 | Uncharacterized protein; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (76 aa) |
| | RPA3 | Replication protein A3. (107 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (782 aa) |
| | KDM4B | Lysine demethylase 4B. (1128 aa) |
| | ENSPCOP00000020344 | Rad60-SLD domain-containing protein. (73 aa) |
| | SUMO2 | Rad60-SLD domain-containing protein. (136 aa) |
| | UBE2I | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | RCBTB2 | RCC1 and BTB domain containing protein 2. (551 aa) |
| | APBB2 | Amyloid beta precursor protein binding family B member 2. (752 aa) |
| | ENSPCOP00000019479 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (60 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (416 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (589 aa) |
| | LOC105824103 | Uncharacterized protein. (430 aa) |
| | TDP2 | Tyrosyl-DNA phosphodiesterase 2. (362 aa) |
| | ENSPCOP00000018904 | Ubiquitin-like domain-containing protein. (131 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (393 aa) |
| | RNF4 | Ring finger protein 4. (190 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (374 aa) |
| | SMARCA1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1. (839 aa) |
| | ATM | ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2635 aa) |
| | RFC5 | AAA domain-containing protein. (338 aa) |
| | RFC4 | Replication factor C subunit 4. (365 aa) |
| | CHEK1 | Checkpoint kinase 1. (454 aa) |
| | RNF8 | Ring finger protein 8. (488 aa) |
| | NSD2 | Nuclear receptor binding SET domain protein 2. (1364 aa) |
| | UBXN1 | UBX domain protein 1. (305 aa) |
| | RAD51D | RAD51 paralog D. (339 aa) |
