STRINGSTRING
AKT1 AKT1 FOS FOS LIF LIF POU2F1 POU2F1 OSM OSM TYK2 TYK2 RORC RORC COL1A2 COL1A2 ITGB1 ITGB1 LOC105818310 LOC105818310 MYC MYC SOCS1 SOCS1 JAK3 JAK3 HMOX1 HMOX1 SOCS5 SOCS5 HIF1A HIF1A JUNB JUNB CCL11 CCL11 ANXA1 ANXA1 LCN2 LCN2 STAT6 STAT6 LOC105818311 LOC105818311 ALOX15 ALOX15 FSCN1 FSCN1 ITGB2 ITGB2 MMP2 MMP2 STAT1 STAT1 IL10 IL10 IL6 IL6 PIM1 PIM1 CCL2 CCL2 GATA3 GATA3 PTGS2 PTGS2 IL23A IL23A BCL6 BCL6 ENSPCOP00000009641 ENSPCOP00000009641 IL13 IL13 CD36 CD36 PIM2 PIM2 IL1B IL1B MUC1 MUC1 MMP9 MMP9 FOXO1 FOXO1 IL12B IL12B IL1A IL1A JAK1 JAK1 TNFRSF1B TNFRSF1B OPRD1 OPRD1 OPRM1 OPRM1 IL17F IL17F TNF TNF LAMA5 LAMA5 FCER2 FCER2 VIM VIM IL12A IL12A IRF4 IRF4 F13A1 F13A1 VCAM1 VCAM1 IL4 IL4 ICAM1 ICAM1 LOC105812452 LOC105812452 HGF HGF PIK3R1 PIK3R1 ENSPCOP00000018566 ENSPCOP00000018566 ENSPCOP00000019392 ENSPCOP00000019392 ZEB1 ZEB1 BIRC5 BIRC5 IL17A IL17A IL13RA2 IL13RA2 IL2RG IL2RG BCL2L1 BCL2L1 BCL2 BCL2 ZEB2 ZEB2 MMP1 MMP1 CCL22 CCL22 MAOA MAOA MMP3 MMP3 RORA RORA RHOU RHOU TGFB1 TGFB1 LOC105818450 LOC105818450 ENSPCOP00000024116 ENSPCOP00000024116 NOS2 NOS2 IL13RA1 IL13RA1 ENSPCOP00000024480 ENSPCOP00000024480 FOXO3 FOXO3 FASLG FASLG BATF BATF MCL1 MCL1 HSP90B1 HSP90B1 SOCS3 SOCS3 S1PR1 S1PR1 BCL6B BCL6B IL6R IL6R TIMP1 TIMP1 GLMP GLMP CCND1 CCND1 STAT3 STAT3 HSP90AA1 HSP90AA1 FGF2 FGF2 IL23R IL23R IL4R IL4R TP53 TP53 LBP LBP POMC POMC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (381 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
POU2F1POU domain protein. (766 aa)
OSMOncostatin M. (251 aa)
TYK2Tyrosine-protein kinase. (1181 aa)
RORCRAR related orphan receptor C. (520 aa)
COL1A2Collagen type I alpha 2 chain. (1364 aa)
ITGB1Integrin beta. (585 aa)
LOC105818310Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (120 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (453 aa)
SOCS1Suppressor of cytokine signaling 1. (223 aa)
JAK3Tyrosine-protein kinase. (1123 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
SOCS5Uncharacterized protein. (536 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
CCL11C-C motif chemokine. (97 aa)
ANXA1Annexin. (346 aa)
LCN2Lipocalin 2; Belongs to the calycin superfamily. Lipocalin family. (197 aa)
STAT6Signal transducer and activator of transcription. (846 aa)
LOC105818311Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (120 aa)
ALOX15Arachidonate 15-lipoxygenase. (663 aa)
FSCN1Fascin. (493 aa)
ITGB2Integrin beta. (764 aa)
MMP2Matrix metallopeptidase 2. (552 aa)
STAT1Signal transducer and activator of transcription. (794 aa)
IL10Interleukin 10. (178 aa)
IL6Uncharacterized protein. (211 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (401 aa)
CCL2C-C motif chemokine. (99 aa)
GATA3Uncharacterized protein. (444 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
IL23AInterleukin 23 subunit alpha. (190 aa)
BCL6BCL6 transcription repressor. (706 aa)
ENSPCOP00000009641Uncharacterized protein. (136 aa)
IL13Interleukin 13. (132 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
PIM2Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (311 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
MUC1SEA domain-containing protein. (168 aa)
MMP9Matrix metallopeptidase 9. (709 aa)
FOXO1Forkhead box O1. (656 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (326 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (270 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
TNFRSF1BTNF receptor superfamily member 1B. (449 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (372 aa)
OPRM1Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. (479 aa)
IL17FInterleukin 17F. (164 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (235 aa)
LAMA5Laminin subunit alpha 5. (3694 aa)
FCER2Fc fragment of IgE receptor II. (306 aa)
VIMVimentin; Belongs to the intermediate filament family. (466 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
IRF4Interferon regulatory factor 4. (451 aa)
F13A1Coagulation factor XIII A chain. (732 aa)
VCAM1Vascular cell adhesion molecule 1. (739 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
ICAM1Intercellular adhesion molecule 1. (533 aa)
LOC105812452HATPase_c domain-containing protein. (680 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (703 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
ENSPCOP00000018566Uncharacterized protein. (113 aa)
ENSPCOP00000019392SOCS box domain-containing protein. (458 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1002 aa)
BIRC5Baculoviral IAP repeat containing 5. (142 aa)
IL17AInterleukin 17A. (153 aa)
IL13RA2Interleukin 13 receptor subunit alpha 2. (285 aa)
IL2RGFibronectin type-III domain-containing protein. (386 aa)
BCL2L1BCL2 like 1. (233 aa)
BCL2BCL2 apoptosis regulator. (234 aa)
ZEB2Zinc finger E-box binding homeobox 2. (1258 aa)
MMP1Matrix metallopeptidase 1. (414 aa)
CCL22C-C motif chemokine. (93 aa)
MAOAAmine oxidase. (528 aa)
MMP3Matrix metallopeptidase 3. (477 aa)
RORARAR related orphan receptor A. (532 aa)
RHOURas homolog family member U. (258 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
LOC105818450Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (122 aa)
ENSPCOP00000024116Uncharacterized protein. (120 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1104 aa)
IL13RA1Interleukin 13 receptor subunit alpha 1. (423 aa)
ENSPCOP00000024480Uncharacterized protein. (103 aa)
FOXO3Forkhead box O3. (672 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (278 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (350 aa)
HSP90B1HATPase_c domain-containing protein. (793 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
BCL6BBCL6B transcription repressor. (475 aa)
IL6RInterleukin 6 receptor. (469 aa)
TIMP1TIMP metallopeptidase inhibitor 1. (207 aa)
GLMPGlycosylated lysosomal membrane protein. (406 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
STAT3Signal transducer and activator of transcription. (796 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (816 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (394 aa)
IL23RInterleukin 23 receptor. (602 aa)
IL4RInterleukin 4 receptor. (808 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
LBPLipopolysaccharide binding protein. (481 aa)
POMCProopiomelanocortin. (258 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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