STRINGSTRING
APEX2 APEX2 SMUG1 SMUG1 PARP1 PARP1 POLE4 POLE4 ATAD5 ATAD5 H2AZ2 H2AZ2 ENSPCOP00000013418 ENSPCOP00000013418 LOC105807652 LOC105807652 MBD4 MBD4 MPG MPG POLE POLE POLD1 POLD1 NTHL1 NTHL1 PARG PARG RFC3 RFC3 LOC105820527 LOC105820527 LOC105808155 LOC105808155 LOC105805702 LOC105805702 MUTYH MUTYH MEIOB MEIOB LOC105805688 LOC105805688 RPA1 RPA1 LOC105805690 LOC105805690 TINF2 TINF2 RFC4 RFC4 RFC5 RFC5 PNKP PNKP LOC105824103 LOC105824103 APEX1 APEX1 TDG TDG RCBTB2 RCBTB2 TERF2 TERF2 TERF1 TERF1 RPA3 RPA3 ENSPCOP00000021297 ENSPCOP00000021297 H2BC5 H2BC5 VWA5B1 VWA5B1 ENSPCOP00000022568 ENSPCOP00000022568 NEIL2 NEIL2 ACD ACD RCBTB1 RCBTB1 POLD4 POLD4 POLD2 POLD2 REC114 REC114 PARP2 PARP2 VWA5B2 VWA5B2 POLD3 POLD3 XRCC1 XRCC1 LOC105824205 LOC105824205 ENSPCOP00000005069 ENSPCOP00000005069 LIG3 LIG3 H2AJ H2AJ POLB POLB LOC105816693 LOC105816693 UNG UNG RFC1 RFC1 TERF2IP TERF2IP H3-4 H3-4 LOC105805679 LOC105805679 ENSPCOP00000028220 ENSPCOP00000028220 ENSPCOP00000028227 ENSPCOP00000028227 LOC105805698 LOC105805698 ENSPCOP00000028467 ENSPCOP00000028467 H2BC11 H2BC11 OGG1 OGG1 RFC2 RFC2 POLE2 POLE2 POLE3 POLE3 NEIL1 NEIL1 LIG1 LIG1 ENSPCOP00000005384 ENSPCOP00000005384 LOC105805692 LOC105805692 LOC105805726 LOC105805726 LOC105805697 LOC105805697 LOC105805682 LOC105805682 PARP3 PARP3 ENSPCOP00000006301 ENSPCOP00000006301 ENSPCOP00000007843 ENSPCOP00000007843 H2BC15 H2BC15 FEN1 FEN1 POT1 POT1 H2AX H2AX H2AC20 H2AC20 H2BC9 H2BC9 ENSPCOP00000003703 ENSPCOP00000003703 NEIL3 NEIL3 LOC105805647 LOC105805647 LOC105821920 LOC105821920 H2AC6 H2AC6 ENSPCOP00000002972 ENSPCOP00000002972 ENSPCOP00000002858 ENSPCOP00000002858 LOC105805699 LOC105805699 LOC105805686 LOC105805686 LOC105805691 LOC105805691 LOC105805703 LOC105805703 ADPRHL2 ADPRHL2 ENSPCOP00000008190 ENSPCOP00000008190 PCNA PCNA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
APEX2DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (518 aa)
SMUG1Uncharacterized protein. (272 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (118 aa)
ATAD5ATPase family AAA domain containing 5. (1646 aa)
H2AZ2Histone H2A; Belongs to the histone H2A family. (129 aa)
ENSPCOP00000013418Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (88 aa)
LOC105807652Histone H2A; Belongs to the histone H2A family. (263 aa)
MBD4Uncharacterized protein. (108 aa)
MPGN-methylpurine DNA glycosylase. (284 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2284 aa)
POLD1DNA polymerase. (1125 aa)
NTHL1Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (312 aa)
PARGPoly(ADP-ribose) glycohydrolase. (970 aa)
RFC3Replication factor C subunit 3. (356 aa)
LOC105820527Uncharacterized protein. (247 aa)
LOC105808155Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC105805702Histone H2A; Belongs to the histone H2A family. (130 aa)
MUTYHAdenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (549 aa)
MEIOBMeiosis specific with OB-fold. (289 aa)
LOC105805688Histone H2B; Belongs to the histone H2B family. (126 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
LOC105805690Histone H2B; Belongs to the histone H2B family. (126 aa)
TINF2TERF1 interacting nuclear factor 2. (451 aa)
RFC4Replication factor C subunit 4. (365 aa)
RFC5AAA domain-containing protein. (338 aa)
PNKPPolynucleotide kinase 3'-phosphatase. (521 aa)
LOC105824103Uncharacterized protein. (430 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
TDGThymine DNA glycosylase. (256 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (551 aa)
TERF2Telomeric repeat binding factor 2. (542 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (435 aa)
RPA3Replication protein A3. (107 aa)
ENSPCOP00000021297Uncharacterized protein; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (76 aa)
H2BC5Histone H2B; Belongs to the histone H2B family. (131 aa)
VWA5B1Von Willebrand factor A domain containing 5B1. (1212 aa)
ENSPCOP00000022568Uncharacterized protein; Belongs to the histone H2B family. (103 aa)
NEIL2Nei like DNA glycosylase 2. (217 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (513 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
POLD4Uncharacterized protein. (107 aa)
POLD2DNA polymerase delta 2, accessory subunit. (504 aa)
REC114REC114 meiotic recombination protein. (235 aa)
PARP2Poly [ADP-ribose] polymerase. (581 aa)
VWA5B2Von Willebrand factor A domain containing 5B2. (1247 aa)
POLD3DNA polymerase delta 3, accessory subunit. (359 aa)
XRCC1X-ray repair cross complementing 1. (598 aa)
LOC105824205Histone H2A; Belongs to the histone H2A family. (112 aa)
ENSPCOP00000005069annotation not available (103 aa)
LIG3DNA ligase. (966 aa)
H2AJHistone H2A; Belongs to the histone H2A family. (129 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (333 aa)
LOC105816693Histone H4. (103 aa)
UNGUracil DNA glycosylase. (261 aa)
RFC1Replication factor C subunit 1. (1113 aa)
TERF2IPTERF2 interacting protein. (393 aa)
H3-4Histone H3; Belongs to the histone H3 family. (136 aa)
LOC105805679Histone H2A type 1. (130 aa)
ENSPCOP00000028220annotation not available (103 aa)
ENSPCOP00000028227annotation not available (103 aa)
LOC105805698Histone H4. (103 aa)
ENSPCOP00000028467Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
H2BC11Histone H2B; Belongs to the histone H2B family. (126 aa)
OGG18-oxoguanine DNA glycosylase. (380 aa)
RFC2Replication factor C subunit 2. (352 aa)
POLE2DNA polymerase epsilon 2, accessory subunit. (439 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (147 aa)
NEIL1Nei like DNA glycosylase 1. (390 aa)
LIG1DNA ligase. (916 aa)
ENSPCOP00000005384annotation not available (103 aa)
LOC105805692Histone H2B type 1. (126 aa)
LOC105805726Histone domain-containing protein; Belongs to the histone H2B family. (126 aa)
LOC105805697Histone H4. (103 aa)
LOC105805682Histone H2A; Belongs to the histone H2A family. (130 aa)
PARP3Poly [ADP-ribose] polymerase. (520 aa)
ENSPCOP00000006301Histone domain-containing protein; Belongs to the histone H2B family. (145 aa)
ENSPCOP00000007843Uncharacterized protein. (432 aa)
H2BC15Histone H2B; Belongs to the histone H2B family. (126 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
POT1Protection of telomeres 1. (600 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (143 aa)
H2AC20Histone H2A; Belongs to the histone H2A family. (129 aa)
H2BC9Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSPCOP00000003703annotation not available (103 aa)
NEIL3Nei like DNA glycosylase 3. (423 aa)
LOC105805647Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC105821920Histone H2B; Belongs to the histone H2B family. (126 aa)
H2AC6Histone H2A; Belongs to the histone H2A family. (130 aa)
ENSPCOP00000002972annotation not available (103 aa)
ENSPCOP00000002858annotation not available (103 aa)
LOC105805699Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
LOC105805686Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC105805691Histone H2B; Belongs to the histone H2B family. (132 aa)
LOC105805703Histone H2B; Belongs to the histone H2B family. (126 aa)
ADPRHL2ADP-ribosylhydrolase like 2. (365 aa)
ENSPCOP00000008190AAA domain-containing protein. (331 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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