Your Input: | |
| | POLR2H | DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa) |
| | LOC105824103 | Uncharacterized protein. (430 aa) |
| | RCBTB2 | RCC1 and BTB domain containing protein 2. (551 aa) |
| | TERF2 | Telomeric repeat binding factor 2. (542 aa) |
| | POLR2D | RNA polymerase II subunit D. (142 aa) |
| | TERF1 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (435 aa) |
| | RPA3 | Replication protein A3. (107 aa) |
| | ENSPCOP00000021297 | Uncharacterized protein; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (76 aa) |
| | H3F3B | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | CENPX | Uncharacterized protein. (79 aa) |
| | H2BC5 | Histone H2B; Belongs to the histone H2B family. (131 aa) |
| | CDK3 | Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (304 aa) |
| | RSF1 | Remodeling and spacing factor 1. (1424 aa) |
| | ENSPCOP00000022568 | Uncharacterized protein; Belongs to the histone H2B family. (103 aa) |
| | RCBTB1 | RCC1 and BTB domain containing protein 1. (531 aa) |
| | ENSPCOP00000022967 | Uncharacterized protein. (277 aa) |
| | RBBP7 | RB binding protein 7, chromatin remodeling factor. (469 aa) |
| | POLD4 | Uncharacterized protein. (107 aa) |
| | RBPMS2 | RNA binding protein, mRNA processing factor 2. (208 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (504 aa) |
| | NPM1 | Uncharacterized protein. (294 aa) |
| | POLR2G | RNA polymerase II subunit G. (178 aa) |
| | TRUB1 | TruB pseudouridine synthase family member 1. (330 aa) |
| | POLD3 | DNA polymerase delta 3, accessory subunit. (359 aa) |
| | POLR2J | RNA_pol_L_2 domain-containing protein. (141 aa) |
| | ENSPCOP00000024841 | Uncharacterized protein. (84 aa) |
| | CENPP | Centromere protein P. (288 aa) |
| | CENPW | Centromere protein W. (88 aa) |
| | RBBP4 | RB binding protein 4, chromatin remodeling factor. (425 aa) |
| | MIS18A | MIS18 kinetochore protein A. (232 aa) |
| | ENSPCOP00000025432 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (747 aa) |
| | KNL1 | Kinetochore scaffold 1. (2298 aa) |
| | POLR2A | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1978 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (442 aa) |
| | TEN1 | Uncharacterized protein. (137 aa) |
| | LOC105824205 | Histone H2A; Belongs to the histone H2A family. (112 aa) |
| | PPP6C | Serine/threonine-protein phosphatase. (305 aa) |
| | NOP10 | NOP10 ribonucleoprotein. (64 aa) |
| | POLR2C | RNA polymerase II subunit C. (275 aa) |
| | H2AJ | Histone H2A; Belongs to the histone H2A family. (129 aa) |
| | HJURP | Holliday junction recognition protein. (738 aa) |
| | LOC105816693 | Histone H4. (103 aa) |
| | RFC1 | Replication factor C subunit 1. (1113 aa) |
| | TERF2IP | TERF2 interacting protein. (393 aa) |
| | H3F3C | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | H3-4 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | LOC105805679 | Histone H2A type 1. (130 aa) |
| | CENPK | Centromere protein K. (247 aa) |
| | CTC1 | CST telomere replication complex component 1. (1221 aa) |
| | ENSPCOP00000028220 | annotation not available (103 aa) |
| | ENSPCOP00000028227 | annotation not available (103 aa) |
| | SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1023 aa) |
| | POLR2F | RNA polymerase II subunit F. (127 aa) |
| | POLA1 | DNA polymerase. (1442 aa) |
| | STN1 | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (369 aa) |
| | H2AZ2 | Histone H2A; Belongs to the histone H2A family. (129 aa) |
| | ENSPCOP00000013418 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (88 aa) |
| | CENPH | Centromere protein H. (192 aa) |
| | LOC105807652 | Histone H2A; Belongs to the histone H2A family. (263 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (643 aa) |
| | POLR2I | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa) |
| | RUVBL1 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (245 aa) |
| | POLD1 | DNA polymerase. (1125 aa) |
| | ENSPCOP00000015216 | Uncharacterized protein. (68 aa) |
| | POLA2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (599 aa) |
| | ATRX | ATRX chromatin remodeler. (2447 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | CENPN | Centromere protein N. (336 aa) |
| | RFC4 | Replication factor C subunit 4. (365 aa) |
| | RFC5 | AAA domain-containing protein. (338 aa) |
| | NHP2 | Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (153 aa) |
| | SMARCA1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1. (839 aa) |
| | CENPI | Centromere protein I. (737 aa) |
| | ANKRD66 | Ankyrin repeat domain 66. (238 aa) |
| | BLM | BLM RecQ like helicase. (1352 aa) |
| | TINF2 | TERF1 interacting nuclear factor 2. (451 aa) |
| | LOC105805690 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) |
| | LOC105805688 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | MEIOB | Meiosis specific with OB-fold. (289 aa) |
| | LOC105812697 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | LOC105808154 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC105805702 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | LOC105808155 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC105817995 | Histone domain-containing protein. (136 aa) |
| | CENPO | Centromere protein O. (300 aa) |
| | LOC105805703 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC105805691 | Histone H2B; Belongs to the histone H2B family. (132 aa) |
| | ENSPCOP00000002346 | Uncharacterized protein. (58 aa) |
| | CENPT | Centromere protein T. (507 aa) |
| | LOC105805686 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC105805699 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | SHQ1 | SHQ1, H/ACA ribonucleoprotein assembly factor. (584 aa) |
| | ENSPCOP00000002776 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (330 aa) |
| | ENSPCOP00000002858 | annotation not available (103 aa) |
| | ENSPCOP00000002972 | annotation not available (103 aa) |
| | ENSPCOP00000003049 | Uncharacterized protein. (437 aa) |
| | H2AC6 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | LOC105821920 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC105805647 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSPCOP00000003703 | annotation not available (103 aa) |
| | H2BC9 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2AC20 | Histone H2A; Belongs to the histone H2A family. (129 aa) |
| | H2AX | Histone H2A; Belongs to the histone H2A family. (143 aa) |
| | POT1 | Protection of telomeres 1. (600 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | WRN | WRN RecQ like helicase. (1049 aa) |
| | H2BC15 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSPCOP00000004829 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (71 aa) |
| | ENSPCOP00000005069 | annotation not available (103 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1286 aa) |
| | ENSPCOP00000005162 | WD_REPEATS_REGION domain-containing protein. (355 aa) |
| | ENSPCOP00000005384 | annotation not available (103 aa) |
| | LOC105805692 | Histone H2B type 1. (126 aa) |
| | LOC105805726 | Histone domain-containing protein; Belongs to the histone H2B family. (126 aa) |
| | RECQL4 | RecQ like helicase 4. (842 aa) |
| | H2AW | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | LOC105805697 | Histone H4. (103 aa) |
| | LOC105805682 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (432 aa) |
| | ENSPCOP00000006301 | Histone domain-containing protein; Belongs to the histone H2B family. (145 aa) |
| | POLR2E | RNA polymerase II subunit E. (210 aa) |
| | CENPL | Centromere protein L. (346 aa) |
| | CHTF18 | Chromosome transmission fidelity factor 18. (998 aa) |
| | CENPM | Centromere protein M. (180 aa) |
| | ENSPCOP00000008190 | AAA domain-containing protein. (331 aa) |
| | DSCC1 | DNA replication and sister chromatid cohesion 1. (393 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | OIP5 | Opa interacting protein 5. (188 aa) |
| | CENPQ | Centromere protein Q. (268 aa) |
| | LOC105811124 | Uncharacterized protein. (256 aa) |
| | ITGB3BP | Centromere protein R; Transcription coregulator that can have both coactivator and corepressor functions. (177 aa) |
| | MIS18BP1 | MIS18 binding protein 1. (1135 aa) |
| | LOC105823602 | Uncharacterized protein. (95 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (621 aa) |
| | LOC105807749 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (284 aa) |
| | PPP6R3 | Protein phosphatase 6 regulatory subunit 3. (879 aa) |
| | ANKRD28 | Ankyrin repeat domain 28. (1083 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | PRIM2 | Uncharacterized protein. (158 aa) |
| | ANKRD44 | Ankyrin repeat domain 44. (910 aa) |
| | ACD | ACD shelterin complex subunit and telomerase recruitment factor. (513 aa) |
| | LIG1 | DNA ligase. (916 aa) |
| | PRIM1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (420 aa) |
| | PPP6R2 | Protein phosphatase 6 regulatory subunit 2. (931 aa) |
| | WRAP53 | WD repeat containing antisense to TP53. (540 aa) |
| | DNA2 | Uncharacterized protein. (833 aa) |
| | RFC2 | Replication factor C subunit 2. (352 aa) |
| | GAR1 | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (196 aa) |
| | RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (397 aa) |
| | ENSPCOP00000028633 | Uncharacterized protein. (58 aa) |
| | H3F3A | Histone domain-containing protein. (137 aa) |
| | H2BC11 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | CENPA | Centromere protein A. (138 aa) |
| | DKC1 | Dyskerin pseudouridine synthase 1. (514 aa) |
| | ENSPCOP00000028467 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | LOC105805698 | Histone H4. (103 aa) |
| | CENPU | Centromere protein U. (300 aa) |
| | DAXX | Death domain associated protein. (739 aa) |
