50 items (Propithecus coquereli) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

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	POLD2	DNA polymerase delta 2, accessory subunit. (504 aa)
	MEIOB	Meiosis specific with OB-fold. (289 aa)
	MUTYH	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (549 aa)
	RCBTB1	RCC1 and BTB domain containing protein 1. (531 aa)
	POLD4	Uncharacterized protein. (107 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
	REC114	REC114 meiotic recombination protein. (235 aa)
	PARP2	Poly [ADP-ribose] polymerase. (581 aa)
	POLD3	DNA polymerase delta 3, accessory subunit. (359 aa)
	VWA5B2	Von Willebrand factor A domain containing 5B2. (1247 aa)
	XRCC1	X-ray repair cross complementing 1. (598 aa)
	LIG3	DNA ligase. (966 aa)
	POLB	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (333 aa)
	UNG	Uracil DNA glycosylase. (261 aa)
	RFC1	Replication factor C subunit 1. (1113 aa)
	OGG1	8-oxoguanine DNA glycosylase. (380 aa)
	RFC2	Replication factor C subunit 2. (352 aa)
	POLE2	DNA polymerase epsilon 2, accessory subunit. (439 aa)
	POLE3	DNA polymerase epsilon 3, accessory subunit. (147 aa)
	NEIL1	Nei like DNA glycosylase 1. (390 aa)
	LIG1	DNA ligase. (916 aa)
	ATAD5	ATPase family AAA domain containing 5. (1646 aa)
	MBD4	Uncharacterized protein. (108 aa)
	MPG	N-methylpurine DNA glycosylase. (284 aa)
	POLE	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2284 aa)
	POLD1	DNA polymerase. (1125 aa)
	NTHL1	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (312 aa)
	PARG	Poly(ADP-ribose) glycohydrolase. (970 aa)
	RFC3	Replication factor C subunit 3. (356 aa)
	LOC105820527	Uncharacterized protein. (247 aa)
	RFC4	Replication factor C subunit 4. (365 aa)
	RFC5	AAA domain-containing protein. (338 aa)
	PNKP	Polynucleotide kinase 3'-phosphatase. (521 aa)
	POLE4	DNA polymerase epsilon 4, accessory subunit. (118 aa)
	PARP1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
	SMUG1	Uncharacterized protein. (272 aa)
	APEX2	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (518 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	ENSPCOP00000008190	AAA domain-containing protein. (331 aa)
	ADPRHL2	ADP-ribosylhydrolase like 2. (365 aa)
	ENSPCOP00000007843	Uncharacterized protein. (432 aa)
	PARP3	Poly [ADP-ribose] polymerase. (520 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
	LOC105824103	Uncharacterized protein. (430 aa)
	APEX1	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
	TDG	Thymine DNA glycosylase. (256 aa)
	RCBTB2	RCC1 and BTB domain containing protein 2. (551 aa)
	RPA3	Replication protein A3. (107 aa)
	VWA5B1	Von Willebrand factor A domain containing 5B1. (1212 aa)
	NEIL2	Nei like DNA glycosylase 2. (217 aa)

Your Current Organism:

Propithecus coquereli

NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADPRHL2	PARG	ENSPCOP00000008044	ENSPCOP00000015656	ADP-ribosylhydrolase like 2.	Poly(ADP-ribose) glycohydrolase.	0.512
ADPRHL2	PARP1	ENSPCOP00000008044	ENSPCOP00000010883	ADP-ribosylhydrolase like 2.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.503
APEX1	APEX2	ENSPCOP00000019229	ENSPCOP00000009434	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	0.865
APEX1	ATAD5	ENSPCOP00000019229	ENSPCOP00000011601	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	ATPase family AAA domain containing 5.	0.710
APEX1	ENSPCOP00000007843	ENSPCOP00000019229	ENSPCOP00000007843	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Uncharacterized protein.	0.497
APEX1	ENSPCOP00000008190	ENSPCOP00000019229	ENSPCOP00000008190	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	AAA domain-containing protein.	0.759
APEX1	FEN1	ENSPCOP00000019229	ENSPCOP00000004555	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.975
APEX1	LIG1	ENSPCOP00000019229	ENSPCOP00000030243	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	DNA ligase.	0.923
APEX1	LIG3	ENSPCOP00000019229	ENSPCOP00000026723	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	DNA ligase.	0.872
APEX1	LOC105820527	ENSPCOP00000019229	ENSPCOP00000016545	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Uncharacterized protein.	0.703
APEX1	LOC105824103	ENSPCOP00000019229	ENSPCOP00000019020	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Uncharacterized protein.	0.530
APEX1	MBD4	ENSPCOP00000019229	ENSPCOP00000013866	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Uncharacterized protein.	0.691
APEX1	MEIOB	ENSPCOP00000019229	ENSPCOP00000000779	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Meiosis specific with OB-fold.	0.580
APEX1	MPG	ENSPCOP00000019229	ENSPCOP00000014125	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	N-methylpurine DNA glycosylase.	0.807
APEX1	MUTYH	ENSPCOP00000019229	ENSPCOP00000001272	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	0.904
APEX1	NEIL1	ENSPCOP00000019229	ENSPCOP00000029390	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Nei like DNA glycosylase 1.	0.443
APEX1	NTHL1	ENSPCOP00000019229	ENSPCOP00000015036	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.	0.993
APEX1	OGG1	ENSPCOP00000019229	ENSPCOP00000028566	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	8-oxoguanine DNA glycosylase.	0.912
APEX1	PARG	ENSPCOP00000019229	ENSPCOP00000015656	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Poly(ADP-ribose) glycohydrolase.	0.668
APEX1	PARP1	ENSPCOP00000019229	ENSPCOP00000010883	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.862