STRINGSTRING
GNG12 GNG12 CYFIP2 CYFIP2 WAS WAS GNB3 GNB3 RELA RELA PRKAR2A PRKAR2A ABI1 ABI1 VAV2 VAV2 WNT5A WNT5A PLK2 PLK2 CD163 CD163 CYFIP1 CYFIP1 GNAI1 GNAI1 ENSPCOP00000007290 ENSPCOP00000007290 HSP90AB1 HSP90AB1 DVL2 DVL2 PRKACB PRKACB WIPF3 WIPF3 GNG8 GNG8 MYO10 MYO10 ARPC1A ARPC1A GNB2 GNB2 GNG10 GNG10 ACTB ACTB ENSPCOP00000004655 ENSPCOP00000004655 GNGT2 GNGT2 MYH9 MYH9 HMOX1 HMOX1 WASF1 WASF1 ITPR2 ITPR2 ARPC1B ARPC1B ENSPCOP00000002927 ENSPCOP00000002927 NCKIPSD NCKIPSD P2RX4 P2RX4 ADCY6 ADCY6 ENSPCOP00000002376 ENSPCOP00000002376 NCKAP1 NCKAP1 ADCY2 ADCY2 NCK1 NCK1 ARPC2 ARPC2 GNG4 GNG4 ENSPCOP00000000994 ENSPCOP00000000994 PRKAR1A PRKAR1A ENSPCOP00000000722 ENSPCOP00000000722 GNAS GNAS GNG7 GNG7 PYCARD PYCARD ELMO2 ELMO2 LOC105810942 LOC105810942 GSDMD GSDMD GNAI2 GNAI2 ADAM17 ADAM17 NOX1 NOX1 MAPK1 MAPK1 ADCY5 ADCY5 BTK BTK PRKACA PRKACA ENSPCOP00000028553 ENSPCOP00000028553 ELMO1 ELMO1 NT5E NT5E MAPK8 MAPK8 ENSPCOP00000027946 ENSPCOP00000027946 TXNIP TXNIP DVL1 DVL1 WIPF2 WIPF2 ACTR2 ACTR2 ENSPCOP00000026249 ENSPCOP00000026249 PTK2 PTK2 PRKAR2B PRKAR2B AHCYL1 AHCYL1 ENTPD1 ENTPD1 ADORA2B ADORA2B ITPR1 ITPR1 DPEP3 DPEP3 DPEP2 DPEP2 LYN LYN PLCG1 PLCG1 NFKB2 NFKB2 WASL WASL ENSPCOP00000024480 ENSPCOP00000024480 ACTR3 ACTR3 ADCY9 ADCY9 CYBA CYBA ADCY7 ADCY7 GNG2 GNG2 ENSPCOP00000023702 ENSPCOP00000023702 GNG13 GNG13 ARPC5 ARPC5 CDC42 CDC42 ACTG1 ACTG1 MAPK10 MAPK10 GNB4 GNB4 GGT5 GGT5 BAIAP2 BAIAP2 GNG11 GNG11 DPEP1 DPEP1 PRKAR1B PRKAR1B PSTPIP1 PSTPIP1 VAV3 VAV3 LOC105811778 LOC105811778 GNB1 GNB1 MYO5A MYO5A NCKAP1L NCKAP1L CREB1 CREB1 ITPR3 ITPR3 SRC SRC FGR FGR CRK CRK GRB2 GRB2 BRK1 BRK1 MAPK14 MAPK14 ADCY3 ADCY3 CD3G CD3G DVL3 DVL3 WASF3 WASF3 CD247 CD247 SUGT1 SUGT1 MYO1C MYO1C LOC105823863 LOC105823863 GGT1 GGT1 ENTPD5 ENTPD5 CASP1 CASP1 GNB5 GNB5 VAV1 VAV1 RHBDF1 RHBDF1 MEFV MEFV WASF2 WASF2 IL1A IL1A C3 C3 GNG3 GNG3 ADCY8 ADCY8 MYO9B MYO9B PLCG2 PLCG2 HCK HCK ADCY4 ADCY4 FURIN FURIN ADCY1 ADCY1 APP APP GNAZ GNAZ IL1B IL1B PRKX PRKX ARPC3 ARPC3 RHBDF2 RHBDF2 ENSPCOP00000009948 ENSPCOP00000009948 CTSG CTSG LOC105821782 LOC105821782 SYK SYK LOC105819868 LOC105819868 WIPF1 WIPF1 TXN TXN ENSPCOP00000008641 ENSPCOP00000008641 FYN FYN MAPK3 MAPK3 IL6 IL6 NFKB1 NFKB1 IL10 IL10
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa)
WASWASP actin nucleation promoting factor. (503 aa)
GNB3G protein subunit beta 3. (340 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (399 aa)
ABI1Abl interactor 1. (508 aa)
VAV2Vav guanine nucleotide exchange factor 2. (771 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
CD163CD163 molecule. (1060 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1244 aa)
GNAI1G protein subunit alpha i1. (354 aa)
ENSPCOP00000007290Uncharacterized protein. (174 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (715 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (399 aa)
WIPF3WAS/WASL interacting protein family member 3. (394 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
MYO10Myosin X; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2080 aa)
ARPC1AUncharacterized protein. (188 aa)
GNB2G protein subunit beta 2. (340 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ACTBActin beta. (378 aa)
ENSPCOP00000004655WD_REPEATS_REGION domain-containing protein. (262 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (88 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1967 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
WASF1WASP family member 1. (559 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2702 aa)
ARPC1BActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (372 aa)
ENSPCOP00000002927Uncharacterized protein. (160 aa)
NCKIPSDNCK interacting protein with SH3 domain. (714 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (402 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1167 aa)
ENSPCOP00000002376Uncharacterized protein. (341 aa)
NCKAP1NCK associated protein 1. (1006 aa)
ADCY2Adenylate cyclase 2. (904 aa)
NCK1Cytoplasmic protein. (377 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (292 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
ENSPCOP00000000994Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (173 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (381 aa)
ENSPCOP00000000722Protein kinase domain-containing protein. (67 aa)
GNASUncharacterized protein. (394 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PYCARDPYD and CARD domain containing. (195 aa)
ELMO2Engulfment and cell motility 2. (720 aa)
LOC105810942WD_REPEATS_REGION domain-containing protein. (347 aa)
GSDMDGasdermin D. (545 aa)
GNAI2G protein subunit alpha i2. (355 aa)
ADAM17ADAM metallopeptidase domain 17. (757 aa)
NOX1NADPH oxidase 1. (564 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1258 aa)
BTKTyrosine-protein kinase. (647 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
ENSPCOP00000028553HATPase_c domain-containing protein. (333 aa)
ELMO1Engulfment and cell motility 1. (727 aa)
NT5E5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (574 aa)
MAPK8Mitogen-activated protein kinase 8. (346 aa)
ENSPCOP00000027946Uncharacterized protein. (298 aa)
TXNIPThioredoxin interacting protein. (397 aa)
DVL1Dishevelled segment polarity protein 1. (722 aa)
WIPF2WAS/WASL interacting protein family member 2. (440 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
ENSPCOP00000026249Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (79 aa)
PTK2Protein tyrosine kinase 2. (1089 aa)
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (418 aa)
AHCYL1Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family. (530 aa)
ENTPD1Ectonucleoside triphosphate diphosphohydrolase 1; Belongs to the GDA1/CD39 NTPase family. (510 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (332 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2732 aa)
DPEP3Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (489 aa)
DPEP2Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (492 aa)
LYNTyrosine-protein kinase. (512 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1304 aa)
NFKB2Nuclear factor kappa B subunit 2. (895 aa)
WASLWASP like actin nucleation promoting factor. (505 aa)
ENSPCOP00000024480Uncharacterized protein. (103 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (418 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
CYBACytochrome b-245 alpha chain. (129 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (109 aa)
ENSPCOP00000023702Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (61 aa)
GNG13G protein subunit gamma 13. (67 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (126 aa)
CDC42Uncharacterized protein. (191 aa)
ACTG1Actin gamma 1. (404 aa)
MAPK10Mitogen-activated protein kinase. (473 aa)
GNB4G protein subunit beta 4. (321 aa)
GGT5Gamma-glutamyltransferase 5. (585 aa)
BAIAP2BAI1 associated protein 2. (544 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
DPEP1Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (408 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (381 aa)
PSTPIP1Proline-serine-threonine phosphatase interacting protein 1. (415 aa)
VAV3Vav guanine nucleotide exchange factor 3. (765 aa)
LOC105811778WD_REPEATS_REGION domain-containing protein. (354 aa)
GNB1G protein subunit beta 1. (334 aa)
MYO5AMyosin VA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1862 aa)
NCKAP1LNCK associated protein 1 like. (1138 aa)
CREB1cAMP responsive element binding protein 1. (280 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2664 aa)
SRCTyrosine-protein kinase. (543 aa)
FGRTyrosine-protein kinase. (495 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
BRK1BRICK1 subunit of SCAR/WAVE actin nucleating complex. (75 aa)
MAPK14Mitogen-activated protein kinase 14. (340 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
CD3GCD3g molecule. (182 aa)
DVL3Dishevelled segment polarity protein 3. (716 aa)
WASF3WASP family member 3. (485 aa)
CD247CD247 molecule. (164 aa)
SUGT1Uncharacterized protein. (333 aa)
MYO1CMyosin IC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1063 aa)
LOC105823863Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GGT1Uncharacterized protein. (569 aa)
ENTPD5Ectonucleoside triphosphate diphosphohydrolase 5 (inactive); Belongs to the GDA1/CD39 NTPase family. (380 aa)
CASP1Uncharacterized protein; Belongs to the peptidase C14A family. (254 aa)
GNB5G protein subunit beta 5. (395 aa)
VAV1Vav guanine nucleotide exchange factor 1. (806 aa)
RHBDF1Rhomboid 5 homolog 1. (855 aa)
MEFVMEFV innate immuity regulator, pyrin. (772 aa)
WASF2WASP family member 2. (497 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (270 aa)
C3Complement C3. (1551 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1229 aa)
MYO9BMyosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2159 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1233 aa)
HCKTyrosine-protein kinase. (524 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (798 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
APPAmyloid beta precursor protein. (772 aa)
GNAZG protein subunit alpha z. (355 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
PRKXUncharacterized protein; Belongs to the protein kinase superfamily. (297 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
RHBDF2Rhomboid 5 homolog 2. (829 aa)
ENSPCOP00000009948Uncharacterized protein. (605 aa)
CTSGCathepsin G; Belongs to the peptidase S1 family. (246 aa)
LOC105821782Uncharacterized protein. (380 aa)
SYKSpleen associated tyrosine kinase. (637 aa)
LOC105819868Protein kinase domain-containing protein. (302 aa)
WIPF1WH2 domain-containing protein. (509 aa)
TXNThioredoxin domain-containing protein. (91 aa)
ENSPCOP00000008641Uncharacterized protein. (715 aa)
FYNTyrosine-protein kinase. (537 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
IL6Uncharacterized protein. (211 aa)
NFKB1Nuclear factor kappa B subunit 1. (961 aa)
IL10Interleukin 10. (178 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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