STRINGSTRING
TGFA TGFA STAT3 STAT3 CEP152 CEP152 MAPK1 MAPK1 PRKCB PRKCB PRKCA PRKCA IL6R IL6R AKT1 AKT1 AKT3 AKT3 ERBB2 ERBB2 FGFR3 FGFR3 ERBB3 ERBB3 NF1 NF1 PDGFRA PDGFRA ENSPCOP00000026233 ENSPCOP00000026233 FOXO3 FOXO3 ENSPCOP00000024796 ENSPCOP00000024796 PDGFA PDGFA PLCG1 PLCG1 BRAF BRAF BCL2L11 BCL2L11 VEGFA VEGFA AXL AXL ENSPCOP00000023046 ENSPCOP00000023046 NRG2 NRG2 GSK3B GSK3B MET MET IGF1R IGF1R BCL2 BCL2 BCL2L1 BCL2L1 HRAS HRAS BAX BAX SHC3 SHC3 IGF1 IGF1 AKT2 AKT2 SRC SRC PIK3R1 PIK3R1 PIK3R2 PIK3R2 EGFR EGFR HGF HGF EIF4EBP1 EIF4EBP1 GRB2 GRB2 ENSPCOP00000017736 ENSPCOP00000017736 PIK3CB PIK3CB EIF4E1B EIF4E1B MAP2K1 MAP2K1 PIK3CA PIK3CA ENSPCOP00000015361 ENSPCOP00000015361 ENSPCOP00000015102 ENSPCOP00000015102 EGF EGF ENSPCOP00000013858 ENSPCOP00000013858 RPS6KB2 RPS6KB2 SHC2 SHC2 GAB1 GAB1 PDGFD PDGFD JAK1 JAK1 CSDE1 CSDE1 EIF4E2 EIF4E2 PLCG2 PLCG2 ARAF ARAF SOS2 SOS2 KRAS KRAS ENSPCOP00000009588 ENSPCOP00000009588 SOS1 SOS1 NRG1 NRG1 PDGFC PDGFC MAPK3 MAPK3 IL6 IL6 PIK3R3 PIK3R3 SHC4 SHC4 PIK3CD PIK3CD NRAS NRAS RAF1 RAF1 KDR KDR PDGFB PDGFB ENSPCOP00000003318 ENSPCOP00000003318 ENSPCOP00000002686 ENSPCOP00000002686 ENSPCOP00000002148 ENSPCOP00000002148 TBCA TBCA PRKCG PRKCG MTOR MTOR PTEN PTEN MAP2K2 MAP2K2 ENSPCOP00000001263 ENSPCOP00000001263 LOC105827009 LOC105827009 GAS6 GAS6 SHC1 SHC1 RPS6KB1 RPS6KB1 FGF2 FGF2 PPP1R14B PPP1R14B PDGFRB PDGFRB BAD BAD FGFR2 FGFR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFATransforming growth factor alpha. (190 aa)
STAT3Signal transducer and activator of transcription. (796 aa)
CEP152Centrosomal protein 152. (1655 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PRKCAUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (575 aa)
IL6RInterleukin 6 receptor. (469 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ERBB2Receptor protein-tyrosine kinase. (1252 aa)
FGFR3Fibroblast growth factor receptor. (807 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1337 aa)
NF1Neurofibromin 1. (2841 aa)
PDGFRAPlatelet derived growth factor receptor alpha; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1027 aa)
ENSPCOP00000026233Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (177 aa)
FOXO3Forkhead box O3. (672 aa)
ENSPCOP00000024796Uncharacterized protein. (442 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1304 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (745 aa)
BCL2L11BCL2 like 11. (200 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
AXLAXL receptor tyrosine kinase. (894 aa)
ENSPCOP00000023046Uncharacterized protein. (150 aa)
NRG2Neuregulin 2. (850 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (390 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1397 aa)
IGF1RTyrosine-protein kinase receptor. (1350 aa)
BCL2BCL2 apoptosis regulator. (234 aa)
BCL2L1BCL2 like 1. (233 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
BAXBCL2 associated X, apoptosis regulator. (199 aa)
SHC3SHC adaptor protein 3. (596 aa)
IGF1Insulin like growth factor 1. (208 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
SRCTyrosine-protein kinase. (543 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIK3R2Uncharacterized protein. (726 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (703 aa)
EIF4EBP1Uncharacterized protein. (118 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
ENSPCOP00000017736Uncharacterized protein. (177 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (236 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (377 aa)
PIK3CAPhosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
ENSPCOP00000015361Uncharacterized protein. (129 aa)
ENSPCOP00000015102Uncharacterized protein. (124 aa)
EGFEpidermal growth factor. (1132 aa)
ENSPCOP00000013858Uncharacterized protein. (78 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (487 aa)
SHC2Uncharacterized protein. (578 aa)
GAB1GRB2 associated binding protein 1. (683 aa)
PDGFDPlatelet derived growth factor D. (349 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
CSDE1Cold shock domain containing E1. (798 aa)
EIF4E2Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (248 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1233 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (609 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (882 aa)
KRASUncharacterized protein. (75 aa)
ENSPCOP00000009588Uncharacterized protein. (316 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
NRG1Neuregulin 1. (710 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (284 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
IL6Uncharacterized protein. (211 aa)
PIK3R3Uncharacterized protein. (454 aa)
SHC4SHC adaptor protein 4. (630 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
ENSPCOP00000003318Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (114 aa)
ENSPCOP00000002686CSD_1 domain-containing protein. (293 aa)
ENSPCOP00000002148Uncharacterized protein. (118 aa)
TBCATubulin-specific chaperone A; Belongs to the TBCA family. (131 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2536 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
ENSPCOP00000001263Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (223 aa)
LOC10582700940S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (246 aa)
GAS6Growth arrest specific 6. (648 aa)
SHC1SHC adaptor protein 1. (582 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (502 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (394 aa)
PPP1R14BUncharacterized protein. (147 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1105 aa)
BADBCL2 associated agonist of cell death. (168 aa)
FGFR2Fibroblast growth factor receptor. (797 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.